Aβ oligomers
An anti diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
... (Aβ) oligomers, synaptotoxins that accumulate in the brains of AD patients, activated the JNK/TNF-α pathway, induced IRS-1 phosphorylation at multiple serine residues, and inhibited physiological IRS-1pTyr ...
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Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice
... mouse-specific Aβ ELISA previously described ...also Aβ, APP, APP fragments, βCTF, or Aβ ...oligomeric Aβ species with the treatment, we performed immunoprecipitation assay of oligomers ...
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Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
... We made prefibrillar oligomer specific monoclonal anti- bodies using the same strategy we employed to make the A11 polyclonal by vaccinating rabbits with A b 40 covalently coupled to colloidal gold particles via a car- ...
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A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid
... While natural oAβ can be readily identified in aqueous extracts of AD brain tissue, attempts to detect soluble oAβ in cerebrospinal fluid (CSF) have led to mixed re- sults, with a few laboratories reporting their ready ...
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Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation
... b oligomers in AD pathogenesis ...Ab oligomers (Figure 5A, C; ...b oligomers, we correlated oligomeric A b levels obtained by A11 dot blot with TDP-43 and TDP-35 levels in 6- and 12-month-old 3×Tg-AD ...
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Protection against ß amyloid induced synaptic and memory impairments via altering ß amyloid assembly by bis(heptyl) cognitin
... β oligomers are considered the main neurotoxin for synaptic dysfunctions and memory impairment in the AD ...and Aβ oligomers simultaneously might not only minimize cholinergic dysfunction but also ...
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Interaction of the amyloid β peptide with sodium dodecyl sulfate as a membrane-mimicking detergent
... how Aβ interacts with lipid mimics and how it is arranged under the var- ious ...in Aβ research ...oligomeric Aβ peptide can be detected by the spin-label EPR methodology ...Aβ1-42 oligomers ...
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Alzheimer's Disease: Synaptic Dysfunction and Aβ
... low-n oligomers bearing some similarities to those detected in human and mouse brain have been detected in the conditioned medium (CM) and/or lysates of a variety of cell lines ...of Aβ species that migrate ...
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Amyloid β-protein oligomers and Alzheimer’s disease
... Aβ has been shown to interact directly with phospho- lipid bilayers. In addition, membrane insertion, ion chan- nel formation, dysregulation of intracellular calcium levels and mitochondrial depolarization all ...
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Using near-infrared enhanced thermozyme and scFv dual-conjugated Au nanorods for detection and targeted photothermal treatment of Alzheimer's disease
... of Aβ, and scFv in particular is prone to binding to Aβ oligomers and ...that Aβ monomers may be of physiological significance to nerve cells in healthy individuals, so an antibody that ...
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Brain amyloid β protein and memory disruption in Alzheimer’s disease
... oligomeric Aβ and finally neuritic plaques is highly dynamic. The specific Aβ species that is correlated with disease severity remains to be ...Oligomeric Aβ has been detected in cultured cells, ...
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Soluble amyloid-β, effect on cerebral arteriolar regulation and vascular cells
... increased Aβ levels affects arteriolar vasomotor function over time, we compared arteriolar diameter responses of vessels from Tg2576 mice, a commonly used AD mouse model having elevated levels of soluble ...
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An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect
... soluble Aβ in both animal and clinical trials [5, ...of Aβ oligomers into fibrils might be an adaptive change in AD; disaggregation A β fi- brils into oligomers in immunotherapies may enhance ...
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Long Term Monoacylglycerol Lipase Inhibitor Treatment Decelerates Pathological Changes in APP/PS1 21 Mice, but Behavioral Improvements Require Early Stage Treatment Onset—Short Report
... After 5 mo treatment with JZL184, the level of Aβ oligomers OMAB immunoreactivity decreased significantly in A, C old p < 0.001 and D, F young p < 0.01 TG mouse groups in all brain areas[r] ...
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Effect of curcumin on accumulation in mononuclear cells and secretion in incubation medium of Аβ(40) and cytokines under local excess of Аβ(42)-homoaggregates
... (Aβ), oligomers and aggregates of which exert toxic and destructive effects upon neural tissue ...of Aβ. Aβ is generally considered to be a toxic molecular waste product ...
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Amyloid beta peptide degradation in cell cultures by mycoplasma contaminants
... Aβ peptides are degraded in cell culture systems and in vivo by at least four peptidases from the metallopeptidase family, neprilysin, endothelin-converting enzyme-1 and - 2, and insulin-degrading enzyme [15]. ...
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The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death
... Coverslips were fixed for 15 min in RT with 4% parafor- maldehyde and permeabilized and blocked with 0.1% Triton X-100 (both from Sigma-Aldrich) and 5% normal goat serum (NGS, Bionordika) in PBS for 30 min at RT. Primary ...
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Tracking amyloid oligomerization with monomer resolution using a 13-amino acid peptide with a backbone-fixed spin label
... track oligomers as they ...the oligomers after gas-phase ionization, the high-field EPR approach presented here determines the oligomers in solution, avoiding chemical separation, vacuum-desorption ...
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DFT Study of Poly Furfuryl Alcohol Rhodamine B Blend
... A theoretical study of poly furfuryle alcohol (PFA), rhodamine B (Rh B) dye and their blends (PFA- Rh B) is carried out by using the density functional theory (DFT). Electronic states and opto-elec- tronic properties are ...
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Aβ Like Peptide Displayed on Bacteriophage T7 Catalyzes Chromate and Uranyl Reduction
... amino-acid Aβ-peptides that have been found to catalyze the NADH-dependent reduction of both chromate and uranyl ...the Aβ-peptide. The surface-displayed Aβ-like peptide on bacteriophage has the ...
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