Aβ peptide
Laminar distribution of β-amyloid (Aβ) peptide deposits in the frontal lobe in familial and sporadic Alzheimer's disease
... of Aβ peptide, while allelic polymorphism of Apo E, and especially the expres- sion of allele ε4, may influence the proportion of the more fibrillogenic Aβ42 formed in the tissue ...of Aβ deposit are ...
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Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease
... the Aβ pep- tide (40–42 amino acids) has been reported (reviewed in ...amyloid peptide accumu- lation in the ...fibrillar Aβ peptide prior to the accumulation of amyloid deposits, A β ...
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Original Article Protective effects of luteolin against cognitive impairment induced by infusion of Aβ peptide in rats
... (Aβ) peptide and the underlying mechanisms in ...ameliorate Aβ-induced learning and memory ...against Aβ-induced cognitive impairment through regulating the cholinergic system and inhibiting ...
8
Retro inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer’s Aβ peptide
... To attach RI-OR2-TAT (Figure 1, A) covalently to the NL surface, we exploited a thiol-maleimide reaction employing an additional cysteine residue to provide the necessary thiol group. 23 This thiol function at the ...
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Lack of evidence of the interaction of the Aβ peptide with the Wnt signaling cascade in Drosophila models of Alzheimer's disease
... formation and stability in the adult organism [4]. In the canonical pathway, the ligand Wnt activates the receptor Frizzled (Fz) and its co-receptor LRP5/6 to induce reorganization of the β-catenin-destruction complex, a ...
5
Amyloid-β-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Aβ peptide. Implications for the pathogenesis of Alzheimer's disease
... The early events triggered in neurons in response to Ab peptide have been largely studied [12-16]. It has been described that Ab oligomers/fibrils induce intracel- lular calcium deregulation that leads to ...
15
The Evolution of Aβ Peptide Burden in the APP23 Transgenic Mice: Implications for Aβ Deposition in Alzheimer Disease
... Histochemical and Immunohistochemical Analyses The right hemispheres from the Tg and non-Tg mice were fixed for 48 hr in 4% paraformaldehyde in 0.1 M phosphate buffer, pH 7.4, the tissue dehydrated with alcohols and ...
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Stereochemistry and amyloid inhibition : asymmetric triplex metallohelices enantioselectively bind to Aβ peptide
... Although both symmetric and asymmetric metallohelices have similar triple-helical structures, they presented different Ab40 inhibition activities and binding affinities as a result of th[r] ...
12
Human Gastrokine 1 and its anti-amyloidogenic properties
... various Aβ peptide fragments derived from the amyloidogenic processing of APP that is first cleavage by β-secretase to generate in the extracellular space the APP soluble domain (sAPP) and the membrane- ...
6
EVALUATION OF NOVEL LIGAND FOR THE MAINTENANCE OF NATIVE Aβ(1 42) PEPTIDE CONFORMATION: RELEVANCE TO ALZHEIMER’S DISEASE
... human Aβ, we concentrated on 2 partial surfaces of this Aβ ...in Aβ helix adjacent to Glu-22 and Asp-23 is a surface containing Phe-20, which connects these residues with Lys-16 and ...of Aβ ...
10
Interaction of the amyloid β peptide with sodium dodecyl sulfate as a membrane-mimicking detergent
... how Aβ interacts with lipid mimics and how it is arranged under the var- ious ...in Aβ research ...oligomeric Aβ peptide can be detected by the spin-label EPR methodology ...that ...
17
Aβ Like Peptide Displayed on Bacteriophage T7 Catalyzes Chromate and Uranyl Reduction
... amino-acid Aβ-peptide, which has been found to catalyze chromate ...these peptide catalysts have the ability to couple naturally occurring electron shuttles present in soils to promote economic ...
12
Amyloid at the cutting edge: activation of α secretase prevents amyloidogenesis in an Alzheimer disease mouse model
... the Aβ peptide domain, its activa- tion may even have the double advantage of not only precluding the neurotoxic Aβ peptide formation but also generating the putatively neuroprotective sAPPα ...
5
Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications
... for Aβ, another specifi c for neurodegeneration to establish AD as the probable pathophysiology) has face validity ...CSF Aβ 1–42 levels across the AD continuum [91], how CSF AD biomarkers and amyloid ...
11
Original Article The protection of acetylcholinesterase inhibitor on β-amyloid-induced injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells
... After incubation with PBS, Aβ, HupA alone or with Aβ for 24 h, cells were harvested, lysed in Passive Lysis Buffer containing protease inhibitors cocktail (Sigma P8430). Lysates were incubated for 30 min on ...
14
Current progress of mitochondrial transplantation that promotes neuronal regeneration
... that peptide-based allogeneic mito- chondrial delivery successfully entered target cells and recovered damaged tissues without triggering significant immune response in PD model, the efficacy of PMD in cerebral ...
12
Soluble amyloid-β, effect on cerebral arteriolar regulation and vascular cells
... increased Aβ levels affects arteriolar vasomotor function over time, we compared arteriolar diameter responses of vessels from Tg2576 mice, a commonly used AD mouse model having elevated levels of soluble ...
12
Mitochondrial β amyloid in Alzheimer's disease
... intracellular Aβ-binding protein and was first identified in 1997 using a yeast two-hybrid screen ...with Aβ (33). However the precise residues involved in the Aβ-ABAD interaction could not be ...
11
Alzheimer's Disease: Synaptic Dysfunction and Aβ
... of Aβ species that migrate in dena- turing SDS-PAGE with molecular weights consistent for Aβ monomer, dimer and trimer ...low-n Aβ oli- gomers. 7PA2 medium containing Aβ low-n oligomers has a ...
14
The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets
... ATP-binding cassette transporters (ABC transporters) ABC transporter is a member of the biggest protein superfamilies, existing in all living organism from micro- organism to human. The human ABC transporter is encoded ...
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