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Systematic review of available evidence on 11 high-priced inpatient orphan drugs

Systematic review of available evidence on 11 high-priced inpatient orphan drugs

... A large share (38%) of full-text publications were excluded because they only provided a summary of available evidence and did not contribute any new knowledge on the particular orphan drug. This high fre- ...

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Evidence at a glance: error matrix approach for overviewing available evidence

Evidence at a glance: error matrix approach for overviewing available evidence

... Step IV of the matrix includes the assessment of the size of the intervention effect, e.g., expressed in numbers- needed-to-treat to obtain benefit or to harm one patient with the intervention. This step is the last one ...

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What is the available evidence that artificial light at night affects animal behaviour? A systematic map protocol

What is the available evidence that artificial light at night affects animal behaviour? A systematic map protocol

... Methods: This systematic map will summarise and examine all available evidence on the effects of ALAN on animal behaviour and ensuing fitness effects. All documented changes to behaviour in animals ...

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Treatment of calcaneal fractures: the available evidence

Treatment of calcaneal fractures: the available evidence

... for return to work, ability to wear shoes and return to nor- mal activities; Bohler’s angle was also improved in the operative groups. The clinical trials had a follow-up no longer than 2 years, so no data on joint ...

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The effectiveness of metal on metal hip resurfacing: a systematic review of the available evidence published before 2002

The effectiveness of metal on metal hip resurfacing: a systematic review of the available evidence published before 2002

... (21,440) in people aged 60 to 74, and 36% (27,965) in people aged 75 and over [4]. Data on the number of revi- sions performed was not so readily available. A previous report suggested that out of approximately ...

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Limited available evidence supports theoretical predictions of reduced vaccine efficacy at higher exposure dose

Limited available evidence supports theoretical predictions of reduced vaccine efficacy at higher exposure dose

... Our simulation suggests that estimates of vaccine efficacy should be much lower under high pathogen challenge dose regardless of susceptibility heterogeneity. While our review revealed a very small number of studies that ...

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A Review of Experimental Studies for Available Evidence on the Use of Prosthetic Material in Hiatal Hernia Repair

A Review of Experimental Studies for Available Evidence on the Use of Prosthetic Material in Hiatal Hernia Repair

... Conclusions: Experimental data are essential in order to fully appreciate the process of repair of a hiatal hernia with a prosthetic material. The articles reviewed provide insight into the properties of different ...

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Tackling obesity in mental health secure units: a mixed method synthesis of available evidence

Tackling obesity in mental health secure units: a mixed method synthesis of available evidence

... on available equipment and trained ...This evidence suggests that physical health promotion delivery can be suboptimal because the priority for busy mental health professionals has been patient safety, for ...

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Designing a rapid response program to support evidence-informed decision-making in the Americas region: using the best available evidence and case studies

Designing a rapid response program to support evidence-informed decision-making in the Americas region: using the best available evidence and case studies

... empirical evidence to support or refute that claim [9, 17, 18, 20, ...comparisons available in the literature of full and rapid reviews to be able to determine the impact of these ...some evidence ...

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A common genetic variation in CEBPE and acute lymphoblastic leukemia: a meta-analysis of the available evidence

A common genetic variation in <em>CEBPE</em> and acute lymphoblastic leukemia: a meta-analysis of the available evidence

... The primary findings of this investigation are the increased OR of childhood ALL susceptibility associated with presence of the rs2239633 SNP in a fixed-effects model, and the l[r] ...

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Shielding Parenteral Nutrition From Light: Does the Available Evidence Support a Randomized, Controlled Trial?

Shielding Parenteral Nutrition From Light: Does the Available Evidence Support a Randomized, Controlled Trial?

... accumulating evidence that photograph pro- tection has beneficial effects in vitro, as well as in animal models, do we still have equipoise to consider a random- ized, controlled trial (RCT) to test the effects of ...

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Aripiprazole for the maintenance treatment of bipolar disorder: a review of available evidence

Aripiprazole for the maintenance treatment of bipolar disorder: a review of available evidence

... Aripiprazole is established as efficacious in the maintenance treatment of BD on the basis of monotherapy and adjunctive data. A consistent finding with aripiprazole is minimal change in body composition and metabolic ...

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REVIEW ARTICLE Is depression an inflammatory condition? A review of available evidence

REVIEW ARTICLE Is depression an inflammatory condition? A review of available evidence

... Mood disorders, especially depressive disorders are prevalent, hard to treat and cause considerable morbidity. There is a bidirectional relationship between mood disorders, especially depression and markers of the ...

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Evidence for the effects of neonicotinoids used in arable crop production on non-target organisms and concentrations of residues in relevant matrices: a systematic map protocol

Evidence for the effects of neonicotinoids used in arable crop production on non-target organisms and concentrations of residues in relevant matrices: a systematic map protocol

... Against this background, legislators and politicians have been faced with a need to use the best available evidence to establish whether registration of some or all of this class of insecticides should ...

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Book Reviews

Book Reviews

... that evidence-based practice is not “cookbook ...best available evidence is not just limited to evidence from randomized controlled trials but also involves the indi- vidual clinician’s ...

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Maintenance of totally implantable central venous catheter access port (port a cath) in oncology: integrating literature review

Maintenance of totally implantable central venous catheter access port (port a cath) in oncology: integrating literature review

... the patient's quality of life and maintenance at longer time intervals compared to other devices (Gomes and Sá, 2014). Alternatively, its disadvantages include flow limitation for apheresis or photopheresis (hemodialysis ...

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Social and behavioral interventions for improving quality of life of HIV infected people receiving antiretroviral therapy: a systematic review and meta-analysis

Social and behavioral interventions for improving quality of life of HIV infected people receiving antiretroviral therapy: a systematic review and meta-analysis

... of the intervention was rated as low or moderate based on the available evidence. A previous systematic review highlighted similar findings that evidence was limited to assess the impact of ...

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Outcome of ultrasound guided closed drainage of acute suppurative thyroid abscess as a definitive treatment modality

Outcome of ultrasound guided closed drainage of acute suppurative thyroid abscess as a definitive treatment modality

... literature available regarding ultrasound guided aspiration of thyroid abscess The best available evidence in the literature are related Deep Neck Abscess as whole and not specific to thyroid abscess ...

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Rigid intramedullary nail fixation of femoral fractures in adolescents: what evidence is available?

Rigid intramedullary nail fixation of femoral fractures in adolescents: what evidence is available?

... Background Femoral fracture in adolescents is a signifi- cant injury. It is generally agreed that operative fixation is the treatment of choice, and rigid intramedullary nail fix- ation is a treatment option. However, ...

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The Ricochet of Magic Bullets: Summary of the Institute of Medicine Report, Adverse Effects of Pertussis and Rubella Vaccines

The Ricochet of Magic Bullets: Summary of the Institute of Medicine Report, Adverse Effects of Pertussis and Rubella Vaccines

... II The available evidence, on balance, does not indicate a causal relation (one or more categories of evidence checked as not supporting causation in Table 1, with evidence supporting ca[r] ...

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