αvβ6 integrin
Pharmacological characterization of the αvβ6 integrin binding and internalization kinetics of the foot-and-mouth disease virus derived peptide A20FMDV2
... Fig.2. Characterisation of [ 3 H]A20FMDV2 αvβ6 integrin binding and RGD integrin selectivity. a Association binding kinetics of [ 3 H]A20FMDV2 to the human αvβ6 integrin. b Dissociation ...
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Study of expression of αvβ6 integrin in potentially malignant lesions: An Immunohistochemistry study
... modulate αvβ6 function by reducing cell surface expression, decreasing ligand binding affinity, and/or interfering with αvβ6 integrin ...Both αvβ6 and COX-2 are expressed in OSCC, both which ...
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The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells
... lacking αvβ6 integrin are protected from exaggerated airway narrowing in a model of allergic ...epithelial integrin αvβ6 is a critical activator of latent TGF-β, and in vitro– differentiated ...
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A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor
... the αvβ6 integrin at ~ 30 min but not at ~ 24 h post-dose, providing evi- dence of target engagement and indicating a duration of target engagement of less than 24 ...
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Dimerization of a Phage-Display Selected Peptide for Imaging of αvβ6- Integrin: Two Approaches to the Multivalent Effect
... Multivalent presentation of a ligand is a well-accepted approach to increase the biological po- tency of a ligand through enhanced ligand-receptor interaction, and in some cases, cellular internalization by surface ...
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A Continuous Bovine Kidney Cell Line Constitutively Expressing Bovine αVβ6 Integrin Has Increased Susceptibility to Foot and Mouth Disease Virus
... Foot-and-mouth disease (FMD) is a worldwide problem limiting the trade of animals and their products from affected countries. The rapid isolation, serotyping, and vaccine matching of FMD virus from disease outbreaks is ...
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αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease
... v6 integrin was only 25 months, which is comparable to the published survival data in ...v6 integrin may represent a distinct endotype of progressive fibrotic ILD and could be useful as a biomarker for ...
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In Vivo Retargeting of Adenovirus Type 5 to αvβ6 Integrin Results in Reduced Hepatotoxicity and Improved Tumor Uptake following Systemic Delivery
... motif in its ligands, which include the latency-associated pep- tides (LAP) of transforming growth factor  1 (TGF-  1) and TGF-  3 (33), in addition to the VP1 structural protein of foot-and-mouth disease virus ...
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A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice
... Figure 1: Gene expression changes in TRAMP prostate through disease progression. qPCR levels of Runx1 (A), Runx2 (B), Histone H4 (C), androgen receptor (AR) (D), αvβ6-Integrin (E), Nkx3.1 (F), Pten (G), ...
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Gastric cancer: biological markers as prognostic factor
... the αvβ6 Integrin is a member of the family and is expressed only in epithelial cells, fibronectin (FN) as your primary ...of αvβ6 is rare and can hardly be detected in normal epithelial cells, but ...
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Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins
... avb3 integrin has been implicated in mediating phagocy- tosis in monocytes and peripheral macrophages, and the avb5 integrin plays a similar role in macrophages and in retinal pigment epithelial (RPE) cells ...
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Ligation of protease activated receptor 1 enhances αv β6 integrin–dependent TGF β activation and promotes acute lung injury
... thermore, we demonstrate that the signal is a direct “inside-out” signal mediated via the small GTPase RhoA and its downstream effector Rho kinase. Finally, we show that during mechanical ventilation, PAR1 stimulation is ...
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Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury
... reabsorbed by the proximal tubule, where they undergo hydrolysis (25). The capability of FLCs to alter proximal tubular cell function greatly exceeded the biological effects of other proteins, such as albumin (29, 30). ...
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Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling
... up-regulates integrin β3 mRNA and protein levels without altering the expression of integrin ...αv. Integrin β3 forms only two α-β heterodimers, αvβ3 and αIIbβ3, both of which are receptors for ...
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Popov, Tzvetan (2011): Characterization of human mesenchymal stem cells by the appearance of integrins and functional analysis of collagen I-binding integrins. Dissertation, LMU München: Medizinische Fakultät
... (Thy-1) and CD105 (endoglin). CD73 is a dimer of two identical subunits glycosylphosphati- dylinositol anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides and ...
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Integrins protect cardiomyocytes from ischemia/reperfusion injury
... CM-specific integrin OE protects against I/R injury in ...of integrin receptors would be cardioprotective, we generated Tg mice with CM-specific OE of α5, α7, or β1D ...individual integrin subunits, ...
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Structure of Adenovirus Complexed with Its Internalization Receptor, αvβ5 Integrin
... 100-kDa integrin heterodimer were pooled and concentrated (C-100 microconcentrator; Amicon) to 2 mg/ml (Bio-Rad protein assay with bovine serum albumin as a standard) and stored at ...of integrin ...
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Radovanac, Korana (2012): Regulation of integrin-linked kinase (ILK) stability. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... ILK is a central scaffolding element of 1 and 3 integrin containing focal adhesions (Hannigan, Leung-Hagesteijn et al. 1996). Taken that ILK regulates many cellular functions such as cell spreading, migration and ...
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The Epithelial Integrin αvβ6 Is a Receptor for Foot-and-Mouth Disease Virus
... of integrin ␣v6 in the infection process is at present unclear ...its integrin receptors, ␣v6 and ...by integrin binding, then it follows that ␣v6 rather than ␣v3 would be more likely to ...
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ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation
... connecting integrin-associated signaling and cell adhesion-mediated radioresistance with DNA repair proteins like DNAPK and ATM remain ...β1 integrin/FAK/JNK1 signaling axis in head and neck cancer cells ...
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