axon degeneration
A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma
... RGC death and axon degeneration [31]. While these previ- ous studies revealed opposing roles for mFasL and sFasL in the pathogenesis of glaucoma, the requirement of the Fas signaling pathway for the ...
15
Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program
... Thus, axon loss during chemotherapy may be due to different injury responses than after ...produce axon degeneration conceptually similar to the complete cessation of axonal transport after nerve ...
18
Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
... promotes axon degeneration after CCCP ...CCCP-induced axon degeneration. As with axon degeneration after axotomy (Di Stefano et ...neurite degeneration following CCCP ...
12
Targeting microtubule alterations in axon degeneration and Alzheimer’s Disease
... excitotoxin-induced axon degeneration, mouse cortical neurons were grown to 10 DIV either on poly-L-lysine coated culture trays or in microfluidic ...the axon compartment of microfluidic chambers and ...
299
The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration
... mature axon tip and in presynaptic terminals at the perisynaptic zone, but RPM-1 is not re- quired for GLO-4 ...the axon tip and the presynaptic terminal via the GLO-4/GLO-1/APM-3 pathway to regulate late ...
18
PubMedCentral-PMC4987202.pdf
... the degeneration of both the soma and axons, occurs extensively during development and in response to various neuronal insults ...the axon terminals and the signal is retrogradely transported to the cell ...
15
Motor neuropathy in porphobilinogen deaminase–deficient mice imitates the peripheral neuropathy of human acute porphyria
... neurological manifestations remains unresolved. We have studied porphyric neuropathy in mice with a partial deficiency of porphobilinogen deaminase (PBGD). PBGD-deficient mice (PBGD –/– ) imitate acute porphyria through ...
9
Distal axon and neuromuscular junction degeneration in amyotrophic lateral sclerosis
... in axon degeneration is not well ...in degeneration of the untreated distal axon and extensive degeneration of neuronal structures in the treated ...distal axon also resulted in ...
11
Distal axon and neuromuscular junction degeneration in amyotrophic lateral sclerosis
... critical for axonal function (Funfschilling et al., 2012). Perturbations to the oligodendrocyte-axon lactate shunt via downregulation of the monocarboxylate transporter 1 (MCT1) in mice results in axon ...
268
Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury
... The faster removal of myelin debris in SIRPα−/− mice compared with wild-type mice (Fig. 3) could have resulted not only from the more efficient phagocytic capacity of SIRPα−/− macrophages compared with wild- type ...
14
Cellular Interactions During Motor Nerve Regeneration
... that axon fragmentation triggers macrophage invasion into the nerve to engulf axonal debris, and that delaying nerve fragmentation in a Wlds model does not alter macrophage recruitment but induces a previously ...
160
IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories
... Fig. 2B shows examples of peak distribution for representative target mRNAs encoding proteins with known functions in axon development: Ncam1, Clasp1, Dcx and Robo2. Over 90% of the identified binding peaks were ...
7
Macromolecular transfer from glia to the axon
... Although the nerve cell body is the major source of the macromolecules which provide the structural integrity of the axon, in some axons the glial cells surrounding the axon also supply [r] ...
16
3D Axon Structure Extraction and Analysis in Confocal Fluorescence Microscopy Images
... each axon object, two points can be found automatically: a seed point estimated from the previous image slice and a DP searched point from DP-based optimal path ...
31
The atypical cadherin flamingo determines the competence of neurons for activity-dependent fine-scale topography
... the axon terminals of M neurons to shift to the ventral side, mixing with the axon terminals of V neurons, resulting in a defect in topography, but this phenotype disappears in the fmi ...of axon ...
8
Axon Surface Infolding and Axon Size can be Quantitatively Related in Gastropod Molluscs
... In axons with infolding, the geometric factor for spike velocity is not the diameter but the square root of the axon volume to surface ratio, or H, as developed by Mirolli & Talbott 1972[r] ...
18
Neuromuscular Physiology of the Longitudinal Muscle of the Earthworm, Lumbricus Terrestris
... When either segmental nerve was stimulated at a frequency of 10 Hz and at a stimulus strength just above threshold for the fast axon, but below threshold for the slow axon, the external [r] ...
16
Chick PTPσ regulates the targeting of retinal axons within the optic tectum
... in axon growth and guidance (Garrity et ...supports axon growth in the optic tract in ...retinal axon growth within the tectum and possibly influence topographic ...
10
Ptpmeg is required for the proper establishment and maintenance of axon projections in the central brain of Drosophila
...  axon branches that arrive after 48 hours PPF and might reflect the failure of these axons to stop their initial ...of axon projections after initial extension remains to be ...of degeneration in ...
11
Role of the SWI/SNF Chromatin Remodelling Complex in the Axon Development of the Drosophila Mushroom Body
... in axon guidance or ...in axon morphogenesis and γ -neuron ...involves degeneration of the larval specific axons, followed by re-extension of the adult specific axonal ...in axon re-extension, ...
85