axon growth
Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems
... dendritic growth and branching in the cortex and hippocampus [51, ...control axon growth, guidance, and branching [8, 53], and in the mouse, Rac1 is required widely in the central and peripheral ...
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The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance
... support axon growth is through cargo transport [52]. Thus, any growth process is in need of building materials, such as lipids, structural proteins, signaling pathway components and cell organelles ...
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Glycogen synthase kinase-3 is required for axon growth and development
... Lgl function in cellular polarity (Hutterer et al., 2004; Plant et al., 2003). More recently, Dvl-1 was found to be colocalized with aPKCζ at the tips of hippocampal neurites and both of them are later enriched at the ...
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Orienting axon growth: spinal nerve segmentation and surround repulsion
... motor axon growth cones (Ranscht and Bronner-Fraser, 1991; Fredette and Ranscht, ...and growth cones might arise indirectly by the disruption of adhesive/attractive interactions between them and the ...
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Axon growth in the adult rat spinal cord
... interfascicular axon growth from embryonic neurons micro-transplanted into minimally disturbed tracts is strictly parallel to the longitudinal (axonal and glial) processes of the host tract (Davies et a ir ...
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Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish
... spatial axon trajectories. Our knowledge of MN axon outgrowth remains ...CaP axon outgrowth defects as observed in slg mutant ...CaP axon outgrowth through activation of islet2 ...
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Stieß, Michael (2010): Studies on microtubule nucleation during axon growth. Dissertation, LMU München: Fakultät für Biologie
... the growth cone, barbed ends are located at the distal membrane and the pointed ends face the T-zone (Pak et ...linked growth cone membrane (Suter and Forscher, ...regulate axon outgrowth and hinder ...
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Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis
... extra axon branches, and are sometimes ...and growth cone filo- podia are longer with increased microtubule ...maintaining axon growth and preventing branching, and suggest that it acts both ...
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Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation
... enhances axon growth from SCG neurons appears to occur shortly after sympathetic axons have arrived at their target tissues and are ramify- ing within and refining connections in these ...
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Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury
... Given that α2δ2 was expressed in the embryonic sensory- motor cortex and in dissociated and cultured E17.5 cortical neurons (Supplemental Figure 2, C–G), we asked whether GBP increases axon growth of ...
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Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex
... To elucidate the pathophysiological relevance of RBFOX1, we focused on the cytoplasmic isoform of Rbfox1 (Rbfox1-iso2) and examined its role during mouse corticogenesis in vivo and in vitro. Knockdown of Rbfox1-iso2 in ...
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Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth promoting activity
... reduce axon growth from all retinal regions, rather than VT axons ...promoting growth of contralateral but not ipsilateral axons across the ...
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Can injured adult CNS axons regenerate by recapitulating development?
... developmental axon growth can promote regeneration in the ...between axon regeneration and functional recovery remains ...cases, axon regeneration is associated with worse functional outcome ...
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Neukirchen, Dorothee (2010): CLIPs regulate neuronal polarization through microtubule and growth cone dynamics. Dissertation, LMU München: Fakultät für Biologie
... the axon is an initial event during the polarization of neurons (Barnes and Polleux, 2009), a critical process for a functioning nervous ...the growth of the axon, but restrain the growth of ...
116
Midline crossing is not required for subsequent pathfinding decisions in commissural neurons
... an axon ventrally, but extended an ipsilateral projection in the anterior direction (Figure ...anterior growth in affected dcc morphants was stochastic or reflected active guidance ...
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Control of Growth Cone Polarity, Microtubule Accumulation, and Protrusion by UNC-6/Netrin and Its Receptors in Caenorhabditis elegans
... on growth cone F-actin polarization and protrusion, and also show that UNC-6/Netrin regulates growth cone microtubule ...drives growth cone protrusion, likely via UNC-40, that is normally restricted ...
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The role of the ezrin radixin moesin (ERM) proteins in development and post injury responses of central nervous system neurons
... 1.2.3.1 Neural Cell Adhesion Molecules The ability of a neuron to extend its axon and innervate targets is to a large extent governed by binding of CAMs on the growth cone to CAMs on the[r] ...
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The extracellular environment of the CNS : influence on plasticity, sprouting, and axonal regeneration after spinal cord injury
... early axon intrinsic, cytoskeleton- associated phase, in which Ca 2+ -dependent activation of calpain proteases leads to cytoskeletal breakdown [27] and (2) a macrophage-dependent phase, in which infiltra- tion of ...
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Pro-neurotrophins secreted from retinal ganglion cell axons are necessary for ephrinA-p75NTR-mediated axon guidance
... the growth medium ...repellent axon guidance (Figure ...out- growth driven by ephrinA reverse signalling is dependent on local secretion of proneurotrophins, which induces an ephrinA-p75 NTR complex ...
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Rod and cone contributions to horizontal cell light responses in the mouse retina
... cell axon is believed to elec- trically isolate the soma from the axon ter- minal in the mammalian ...and axon terminals differed in sensitivity; thus, rod signals could not be reaching the soma via ...
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