Axon guidance
MUC4-promoted neural invasion is mediated by the axon guidance factor netrin-1 in PDAC
... potential and confers apoptosis resistance in PC [38]. To assess whether netrin-1 mediated the effect of MUC4 on PDAC NI, we investigated netrin-1 expression in Colo-357 shMUC4 and Capan-1 shMUC4 cells. Our data showed ...
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Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism
... Real-time RT-PCR revealed that the relative expression levels of EFNB3, PLXNA4A and ROBO2, compared, with all three housekeeping genes were significantly lower in the ACC of people with autism than in the ACC of con- ...
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JMJD 1 2/PHF8 controls axon guidance by regulating Hedgehog like signaling
... counterparts (Kuwabara et al., 2000; Hao et al., 2006b; Soloviev et al., 2011). As the defects observed in jmjd-1.2 mutants are related to increased expression of Hh-related genes, we speculated that a negative ...
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Semaphorin 6B acts as a receptor in post crossing commissural axon guidance
... of axon guidance cues and their receptors on growth cones directs axonal navigation through the pre-existing ...for axon guidance. A number of long-range guidance cues directing these ...
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Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA mediated motor axon guidance
... The deletion of the Gyc76C PBM strongly suppresses cGMP production by FL Gyc76C, and Gyc76C variants lacking the PBM motif exhibit low cell-surface expression levels, suggesting dGIPC regulates Gyc76C cell-surface ...
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The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development
... persistent axon outgrowth not by accelerating axon growth velocity but by reducing spon- taneous axon retraction ...mediates axon guidance, as reduction in TACC3 levels results in ...
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Signal Transduction Mechanisms in Commissural Axon Guidance: The Role of Intracellular Tyrosine Kinases in Netrin-Dcc/Frazzled Axon Attraction
... Midline axon guidance signaling allows the establishment of left-right connectivity in bilaterally symmetric ...Many guidance cues and their respective receptors that operate at this guidance ...
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Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance
... cell neurons shows the immediate past history of filopodial behavior. Lin, C.H., and Forscher, P. (1993). Cytoskeletal remodeling during Proc. Natl. Acad. Sci. USA 96, 7928–7931. growth cone-target interactions. J. Cell ...
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A GATA/homeodomain transcriptional code regulates axon guidance through the Unc 5 receptor
... regulate axon pathfinding remains poorly ...motor axon projection towards dorsal muscles in ...controls axon guidance, in part, by regulating the level of unc-5 ...
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belladonna/(lhx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain
... We have identified a zebrafish Lim-homeodomain protein that appears to be orthologous to Lhx2 based both on sequence similarity and embryonic expression pattern (Bachy et al., 2001; Nohno et al., 1997). Our analyses show ...
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A critical role for STIM1 in filopodial calcium entry and axon guidance
... We first cloned Xenopus STIM1 (XSTIM1; 668 a.a.), which exhibited 72.8% identity to human STIM1 (685 a.a.; Additional file 1: Figure S1). Whole-mount in situ hy- bridization of developing Xenopus embryos showed that ...
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Semaphorin Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance
... by guidance factors located at defined ‘decision points’ along axonal paths ...of guidance molecules, supported by the development and proper assembly of intermediate targets, is therefore just as essential ...
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Getting axons onto the right path: the role of transcription factors in axon guidance
... al., 2004; Layden et al., 2006) (Fig. 2). The loss of activity of these proteins does not appear to affect other parameters of MN identity, but does restrict their outgrowth potential. It is presumed that these molecules ...
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Nectin like molecules/SynCAMs are required for post crossing commissural axon guidance
... aberrant axon guidance at 53% and 58%, respectively, of the injection ...similar guidance defects as seen in the absence of ...commissural axon guidance in rat hindbrain ...comparable ...
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Axon guidance receptors direct growth cone pathfinding: rivalry at the leading edge
... The ability of Eph receptors to phosphorylate other components within a multi-molecular complex may also have significant repercus- sions for the type of response evoked. Recent experiments have demonstrated that ...
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EFN 4 functions in LAD 2 mediated axon guidance in Caenorhabditis elegans
... in axon guidance has been demonstrated for the VAB-1/Eph receptor (Boulin et ...promoting axon branching that is also partially independent of VAB-1 (Schwieterman et ...
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Early expression of axon guidance molecules in the embryonic chick mesencephalon and pretectum
... several axon guidance molecules are correlated with the longitudinal ...these guidance cues control commissure formation, with Netrin acting as attractant and Slit as repellent (reviewed in Chilton, ...
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Commissural axon guidance in the developing spinal cord: from Cajal to the present day
... Studies of commissure formation have revealed remark- ably conserved molecular mechanisms of axon guidance that coordinate midline crossing [38]. Thus, rather than being a byproduct of an embryological ...
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Regulation Of Axon Guidance Receptor Expression And Activity During Neuronal Morphogenesis
... motor axon guidance (Fujioka et al., 2003). Eve may regulate guidance through Hb9, as hb9 is de-repressed in eve mosaic mutants, and rescue experiments suggest a correlation between the extent of ...
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The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans
... longitudinal axon tracts, most notably the VNC, these genes encode adhesion molecules, putative receptors components of signal transduction pathways or cytoskeletal regulators, but not clearly defined tropic ...
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