axon pathfinding
Cxcl12/Cxcr4 chemokine signaling is required for placode assembly and sensory axon pathfinding in the zebrafish olfactory system
... Positioning neurons in the right places and wiring axons to the appropriate targets are essential events for establishment of neural circuits. In the zebrafish olfactory system, precursors of olfactory sensory neurons ...
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LRP receptors in a novel mechanism of axon pathfinding and peripheral nerve regeneration
... in axon pathfinding and neuronal migration, and through regulation of NMDA receptor activity has roles in learning and memory (Krystosek and Seeds, 1981, Hu et ...
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The novel Rac effector RIN 1 regulates neuronal cell migration and axon pathfinding in C elegans
... mutants show severe defects (Wu et al., 2002). However, no defects were observed in rin-1 mutants, and no genetic interactions were found in any rin-1 double mutants (Table 1). In ced-10 mutant animals, many cell corpses ...
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Interactions of UNC-34 Enabled With Rac GTPases and the NIK Kinase MIG-15 in Caenorhabditis elegans Axon Pathfinding and Neuronal Migration
... Our data suggest that MIG-2 Rac is involved in both MIG-15–dependent cell polarity and CED-10/RAC-2/ UNC-34–dependent cell migration, as mig-2(mu28) en- hanced the PQR direction of migration defects of mig-15(rh148) and ...
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Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification
... Tv axon pathfinding may be one such ...ap-dependent axon pathfinding of dAp and vAp neurons; dAp axons crucially depend upon eya to avoid crossing the midline, whereas vAp axons neither ...
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Slit and Netrin-1 guide cranial motor axon pathfinding via Rho-kinase, myosin light chain kinase and myosin II
... striking axon pathfinding defects [7], we expressed dominant negative forms of the Netrin receptor Unc5A in chick ...motor axon responses to ...normal axon paths, projecting a single ...
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Semaphorin and neuropilin co expression in motoneurons sets axon sensitivity to environmental semaphorin sources during motor axon pathfinding
... Class III semaphorins (SemaIIIs) are intercellular cues secreted by surrounding tissues to guide migrating cells and axons in the developing organism. This chemotropic activity is crucial for the formation of nerves and ...
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The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding
... Background: Neuronal growth cones follow specific pathways over long distances in order to reach their appropriate targets. Research over the past 15 years has yielded a large body of information concerning the molecules ...
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Sonic hedgehog is indirectly required for intraretinal axon pathfinding by regulating chemokine expression in the optic stalk
... for axon pathfinding was not ...intraretinal pathfinding errors, the loss of one allele of cxcl12a in shha mutants significantly increases the intraretinal pathfinding phenotype compared with ...
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Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth promoting activity
... percentage axon coverage and neurite length from VT retinae grown with chiasm cells were much lower (66-93% less) than from DN retinae grown with chiasm cells and from VT retinae grown without chiasm cells ...
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How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?
... During embryogenesis, neurons connect with their synaptic partners to form functional circuits in a process called axon path fi nding. Growth cones, located at the distal tips of growing axons respond or “steer” ...
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Slit mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain
... levels, axon stalling was also frequently observed within the Slit-Myc expressing domain ...motor axon growth is inhibited in response to ectopic Slit protein in ...normal axon projections with no ...
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Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo
... for axon guidance, the motor axon phenotypes observed in MMP mutants could be expected to be identical to or opposite that of the phenotypes displayed by substrate ...normal axon outgrowth, Sema-Plex ...
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IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories
... commissural axon pathfinding in vivo ...commissural axon ipsilateral segment (green), contralateral segment (red) and the floor plate (blue) are ...shows axon segments approaching the floor ...
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Axon guidance receptors direct growth cone pathfinding: rivalry at the leading edge
... drives axon pathfinding throughout the developing CNS and PNS via a chemorepulsive mechanism (for comprehensive reviews see: Holder and Klein, 1999; Wilkinson, ...retinal axon terminations along both ...
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Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits
... direct axon pathfinding, it is essential to identify downstream signaling molecules that allow these receptors to communicate with elements of the ...controls axon navigation in vivo. Netrin is ...
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Ptpmeg is required for the proper establishment and maintenance of axon projections in the central brain of Drosophila
... EB axon defects of ptpmeg mutants, none of the three phosphatase domain mutants significantly rescued EB defects ...EB axon or MB axon phenotype in an otherwise normal ...EB axon ...
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Syndecan regulates cell migration and axon guidance in C elegans
... outgrowing axon while leaving other neurons ...of axon guidance choices (Lee and Chien, ...in axon pathfinding (Bülow and Hobert, 2004; Inatani et ...
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Direction oriented pathfinding in video games
... problem, pathfinding has an unneglectable indirect impact on gaming ...Oriented Pathfinding (DOP) which can provide a high quality solution without sacrificing ...
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Rod and cone contributions to horizontal cell light responses in the mouse retina
... This possibility has been difficult to test because of inadequate experimental procedures: previous studies distinguished rod from cone signals using stimuli of different wavelengths; how- ever, this method provides only ...
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