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Axon Regeneration

N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans

N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans

... as axon regeneration in mammals and zebrafish (Breen et ...during axon regeneration in ...that axon regeneration in ...in axon regenera- ...

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Meningeal cells and glia establish a permissive environment for axon regeneration after spinal cord injury in newts

Meningeal cells and glia establish a permissive environment for axon regeneration after spinal cord injury in newts

... Axons appear to be able to regenerate after an SCI in the newt in part because the environment of the injury site is not inhibitory. Instead of forming a dense inhi- bitory scar and interacting to form a glia limitans ...

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Distinct cellular and molecular mechanisms mediate initial axon
development and adult stage axon regeneration in C  elegans

Distinct cellular and molecular mechanisms mediate initial axon development and adult stage axon regeneration in C elegans

... axon regeneration after adult-stage ...initial axon development in the AVM mechanosensory neurons are particularly well understood, providing an opportunity for detailed analysis of the molecular ...

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Upregulation of the zebrafish Nogo-A homologue, Rtn4b, in retinal ganglion cells is functionally involved in axon regeneration

Upregulation of the zebrafish Nogo-A homologue, Rtn4b, in retinal ganglion cells is functionally involved in axon regeneration

... To determine whether Rtn4b is indeed needed for RGC axon regeneration, we downregulated Rtn4b by placing a MO-soaked piece of gel foam directly at the eye-sided optic nerve at the time of ONS [17]. The MOs ...

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The PACAP-derived peptide MPAPO facilitates corneal wound healing by promoting corneal epithelial cell proliferation and trigeminal ganglion cell axon regeneration

The PACAP-derived peptide MPAPO facilitates corneal wound healing by promoting corneal epithelial cell proliferation and trigeminal ganglion cell axon regeneration

... homeostasis and controls tissue self-renewal [28]. The Wnt signaling pathway is activated in three distinct ways: the classic Wnt/β-catenin signaling pathway, the planar cell polarity (PCP) signaling pathway and the ...

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Erratum to: Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB

Erratum to: Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB

... 1. Lin S, Liang Y, Zhang J, Bian C, Zhou H, Guo Q, Xiong Y, Li S, Su B: Microglial TIR-domain-containing adapter-inducing interferon- β (TRIF) deficiency promotes retinal ganglion cell survival and axon ...

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Expression of an activated integrin promotes long distance sensory axon regeneration in the spinal cord

Expression of an activated integrin promotes long distance sensory axon regeneration in the spinal cord

... Axons will not grow unless they have on their surface a receptor that recognizes a ligand in their environment. Our previous work has identified ␣ 9 integrin as such a receptor, recognizing tenascin-C, which is present ...

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Original Article Icariside II affects hippocampal neuron axon regeneration and improves learning and memory in a chronic cerebral hypoperfusion rat model

Original Article Icariside II affects hippocampal neuron axon regeneration and improves learning and memory in a chronic cerebral hypoperfusion rat model

... promote axon regeneration by regulating GAP-43, MAP-2 and Nogo-A protein expression levels and improve cognitive ability in CCH ...regulate axon regeneration require further veri- ...

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The C  elegans peroxidasin PXN 2 is essential for embryonic morphogenesis and inhibits adult axon regeneration

The C elegans peroxidasin PXN 2 is essential for embryonic morphogenesis and inhibits adult axon regeneration

... Peroxidasins form a highly conserved family of extracellular peroxidases of unknown cellular function. We identified the C. elegans peroxidasin PXN-2 in screens for mutants defective in embryonic morphogenesis. We find ...

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CNS axon regeneration inhibitors stimulate an immediate early gene response via MAP kinase-SRF signaling

CNS axon regeneration inhibitors stimulate an immediate early gene response via MAP kinase-SRF signaling

... these axon re- generation inhibitors modulate gene ...axonal regeneration so far. In PNS axon regeneration, using facial nerve regeneration as model system, we demonstrated a ...

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Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

... central axon regeneration and several mole- cules initially identified using this paradigm were later found to increase regeneration of other unrelated ...axonal regeneration of other tracts, ...

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The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans

The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans

... of axon outgrowth and ...regulating axon guidance, including Netrin signaling, the slit Slit/Robo pathway, Wnt signaling, and ...others. Axon guidance factors were fi rst identi fi ed by screens for ...

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Eph Receptor Clustering by Chondroitin Sulfate Inhibits Axon Regeneration

Eph Receptor Clustering by Chondroitin Sulfate Inhibits Axon Regeneration

... of axon regrowth has been linked to inhibitory extracellular matrix molecules produced in response to CNS damage 2,3 ...prevent axon regeneration and impede functional recovery following injury to ...

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Original Article Qualitative analysis of axon regeneration by semi-automatic programs on axon photomicrographs proven through concepts of calculus

Original Article Qualitative analysis of axon regeneration by semi-automatic programs on axon photomicrographs proven through concepts of calculus

... of axon counts, axon calibers, and g-ratios are time consuming and can be biased by observer ...for axon counts, axon calibers, or axon g-ratios between semi-automatic and manual ...for ...

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Chromatolysis: Do Injured Axons Regenerate Poorly when Ribonucleases Fragment or Degranulate Rough Endoplasmic Reticulum, Disaggregate Polyribosomes, Degrade Monoribosomes and Lyse RNA?

Chromatolysis: Do Injured Axons Regenerate Poorly when Ribonucleases Fragment or Degranulate Rough Endoplasmic Reticulum, Disaggregate Polyribosomes, Degrade Monoribosomes and Lyse RNA?

... denied axon regeneration, chromatolysis is often accompanied by degranulation (loss of ribosomes from rough endoplasmic reticulum), disaggregation of polyribosomes and degradation of monoribosomes into ...

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Immunophilin ligands in peripheral nerve regeneration

Immunophilin ligands in peripheral nerve regeneration

... nerve regeneration studies, mostly there is a certain denervation time of the affected nerve between lesion and ...of axon regeneration was ...extensive axon regeneration and fewer ...

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Can injured adult CNS axons regenerate by recapitulating development?

Can injured adult CNS axons regenerate by recapitulating development?

... the axon (Kang et ...and axon regeneration (Cartoni et ...and axon regeneration (Cartoni et ...for axon regeneration in the nematode, ...influences regeneration. ...

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Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury

Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury

... Human periodontal ligament-derived stem cells promote retinal ganglion cell survival and axon regeneration after optic nerve injury.. Therapeutic effect of adiposederived stem cell trans[r] ...

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Phosphorylation sites of microtubule-associated protein 1B (MAP 1B) are involved in axon growth and regeneration

Phosphorylation sites of microtubule-associated protein 1B (MAP 1B) are involved in axon growth and regeneration

... Next, we examined whether these phosphorylation sites serve as molecular markers of regenerating axons as well as GAP-43 pS96 [21]. We chose the crushed sciatic nerve injury as a model of axon regeneration ...

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Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling

<p>Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling</p>

... for the growth, maintenance and regeneration of axons. A previous study reported that NF200 re fl ects the morpho- logical changes of neuron axons and the state of axon growth or repair. 21 Therefore, NF-200 ...

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