axonal transport
Axonal Transport: A Constrained System
... intracellular axonal transport is predominantly microtubule- based, and its impairment is linked to ...cargo transport in small (but not large) caliber ...For transport toward the minus-end of ...
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Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features
... Methods: Here, we investigated the impact of short-term diabetes in the peripheral nervous system of male and female rats on key motor proteins important for axonal transport, mitochondrial function, and ...
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Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations
... microtubule-based axonal transport is hypothesized to contribute to Parkinson’s disease, but whether LRRK2 mutations affect this process to mediate pathogenesis is not ...inhibits axonal ...
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Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein
... 26]. Axonal transport of APP involves its loading onto calsyntenin-1 containing vesicles in the Golgi ...anterograde axonal transport of APP and also promotes BACE1 cleavage of APP to in- ...
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Cerebrospinal fluid–based kinetic biomarkers of axonal transport in monitoring neurodegeneration
... of axonal transport (43) showed slowing with aging, particularly for slow axonal transport of ...the transport abnormali- ties in the PD patients were simply a result of their older ...
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The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons
... Damaged mitochondria can be harmful and degraded by a form of autophagy known as mitophagy. Successful removal of damaged mitochondria could be critical for maintaining axonal health and limiting secondary dam- ...
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Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation
... of axonal transport serves to move components over very long distances on microtubule tracks in order to maintain neuronal ...long-distance transport in the context of neuro- degenerative ...in ...
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Retrograde Axonal Transport: a Major Transmission Route of Enterovirus 71 in Mice
... peripheral nerves (23). We previously showed that EV71 prop- agated more effectively in RD (human rhabdomyosarcoma) cells than in SK-N-SH (neuroblastoma) cells and Caco-2 (colo- rectal adenocarcinoma) cells. Furthermore, ...
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Dual Role of Herpes Simplex Virus 1 pUS9 in Virus Anterograde Axonal Transport and Final Assembly in Growth Cones in Distal Axons
... anterograde transport and assembly of HSV-1 in the distal axon of human and rat dorsal root ganglion (DRG) neurons using US9 deletion (US9 ⴚ ), repair (US9R), and wild-type (strain F, 17, and KOS) ...anterograde ...
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Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?
... kinesin-1-mediated transport (Hammond et ...dynein-mediated transport is less clear, but increasing -tubulin acetylation has been shown to cause recruitment of dynein to microtubules (Dompierre et ...affect ...
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Axonal Transport and Sorting of Herpes Simplex Virus Components in a Mature Mouse Visual System
... Moreover, embryonic in vitro neurites contain the cell ma- chinery necessary for synthesis of new proteins. Thus, viral protein synthesis theoretically might also occur in situ within the neurite (1, 6). In contrast, ...
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Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport
... Fabrication of microfluidic chambers and analysis of mitochondrial axonal transport were described in the reference [24]. In brief, neurons cultured in microfluidic chambers were transfected with ...
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Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria.
... terograde axonal transport of mitochondria, and attachment of kinesin-1 to mitochondria involves the outer mitochondrial protein Miro1 and the adaptor protein TRAK1 ...anterograde transport of ...
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Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy
... by axonal transport was significantly reduced in a human neuronal model of sporadic ...reduced axonal transport in the pathogenesis of ...
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Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43
... ABSTRACT Human coronaviruses (HCoVs) are recognized respiratory pathogens for which accumulating evidence indicates that in vulnerable patients the infection can cause more severe pathologies. HCoVs are not always ...
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The GDVII Strain of Theiler’s Virus Spreads via Axonal Transport
... of transport in the sciatic nerve was approximately 20 mm/day, which is con- sistent with fast axonal transport (for a review, see reference ...fast axonal transport by using ...
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Axonal transport defects are a common phenotype in Drosophila models of ALS
... Defective axonal transport is hypothesized to be a key factor in the selective vulnerability of motor nerves due to their extraordinary length and evidence that ALS occurs as a distal ...axonopathy. ...
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Axonal degeneration in paraplegin deficient mice is associated with abnormal mitochondria and impairment of axonal transport
... diseases, axonal degeneration occurs before neuronal death and con- tributes significantly to patients’ ...by axonal swelling and ...test. Axonal swellings occur through massive accumulation of ...
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LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains
... fundamental transport processes within axons includ- ing those driven by kinesin-1 and myosin ...both axonal transport and neuronal signal- ing functions which are all perturbed in ...facilitates ...
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Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases
... the axonal and somato-dendritic ...Mitochondrial transport was imaged in both the cell body and axon chambers before ...Mitochondrial transport in axon chamber was severely inhibited 90 m after ...
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