Azole resistance
A Novel Environmental Azole Resistance Mutation in Aspergillus fumigatus and a Possible Role of Sexual Reproduction in Its Emergence
... to azole fungicides. These obser- vations confirm our concern that new azole resistance mutations will continue to emerge in the environment if we persevere with our current practices of azole ...
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Genotypic Evolution of Azole Resistance Mechanisms in Sequential Candida albicans Isolates
... mediate azole resistance in Candida ...High azole resistance levels are achieved when ...containing azole-susceptible and -resistant strains were analyzed for the TAC1 and ERG11 alleles ...
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Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance
... drug resistance and virulence in ...fluconazole resistance; however, it was important for the azole tolerance of some clinical isolates, potentially enabling the evolution of drug resistance in ...
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The Aspergillus fumigatus Mismatch Repair MSH2 Homolog Is Important for Virulence and Azole Resistance
... We previously investigated the A. fumigatus AtmA (Ataxia-telangiectasia mutated) and AtrA kinases and how they impact virulence and the evolution of azole resistance (19). We have observed that genetic ...
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Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola
... for resistance associated with CYP51 changes in ...any azole in any of the variant proteins, providing the potential for an in silico screening system for azole binding in fungal ...of ...
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Molecular Epidemiology of Aspergillus fumigatus Isolates Harboring the TR34/L98H Azole Resistance Mechanism
... A spergillus fumigatus is a saprophytic fungus that is capable of causing a wide range of diseases in various hosts. Invasive aspergillosis is the most severe manifestation of Aspergillus infec- tion in humans, and this ...
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Nonrandom Distribution of Azole Resistance across the Global Population of Aspergillus fumigatus
... that azole-resistant isolates are geneti- cally depauperate compared to their wild-type counterparts, compatible with selec- tive sweeps accompanying the selection of beneficial ...that azole-resistant ...
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Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole Genome Sequencing
... of azole resistance mechanisms in other pathogenic fungi, such as Candida albicans (45) and Cryptococcus neoformans ...evolve resistance to azole ...either azole-sensitive or ...
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AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus
... with azole-resistant Aspergillus fumigatus has a mortality rate that can approach 90% in certain patient ...for azole resistance involves changes in the cyp51A gene that encodes the target of ...
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Role of Ndt80p in Sterol Metabolism Regulation and Azole Resistance in Candida albicans
... the azole inducibility of ERG genes (ERG3, ERG4, ERG6, ERG7, ERG11, ERG24, ERG25) is indeed dependent on Ndt80p ...drug resistance, this is consistent with the reduction of ERG gene expression and the ...
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Quantification of CDR1 Gene Expression in Fluconazole Resistant Candida Glabrata Strains Using Real-time PCR
... fluconazole resistance (13, 14). Azole resistance in ...multidrug resistance (MDR1) gene, which codes for a major facilitator transporter” (15, ...
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Bloodstream infections in patients with hematological malignancies: which is more fatal – cancer or resistant pathogens?
... Carbapenem resistance and then colistin based therapy should be considered in patient with risk factors for colonization or infection caused by carbap- enem resistant ...
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UPC2 Is Universally Essential for Azole Antifungal Resistance in Candida albicans
... the azole antifungals in azole- resistant as well as azole-susceptible ...in azole antifungal activity against both azole-susceptible and azole-resistant strains of ...an ...
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Contributions of Aspergillus fumigatus ATP-Binding Cassette Transporter Proteins to Drug Resistance and Virulence
... In yeast cells such as those of Saccharomyces cerevisiae, expression of ATP-binding cassette (ABC) transporter proteins has been found to be increased and correlates with a concomitant elevation in azole drug ...
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Culture Based Methods and Molecular Tools for Azole Resistant Aspergillus fumigatus Detection in a Belgian University Hospital
... unselected azole-resistant ...of azole-resistance among all patients (approximately 13%) and among patients with probable or proven IA (approximately ...of azole-resistant ...of ...
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<em>Aspergillus fumigatus</em> in the cystic fibrosis lung: pros and cons of azole therapy
... of azole resistance has remained unknown because most clinical laboratories do not routinely perform susceptibility testing of clinical ...of azole-resistant isolates in CF sputum (Table ...in ...
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Worldwide emergence of resistance to antifungal drugs challenges human health and food security
... , Azole Resistance in Aspergillus fumigatus Clinical Isolates from an 418.. Italian Culture Collection.[r] ...
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Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients
... between azole and protein, often resulting in azole ...drug resistance genes (i.e., CDR1 and CDR2), and multiple drug resistance genes ...
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AZOLE SUSCEPTIBILITY AND RESISTANCE IN CANDIDA DUBLINIENSIS
... albicans, resistance to azole drugs has also been as- sociated with modifications of the ergosterol biosynthetic pathway, such as defects in the sterol C5,6-desaturation step that avoid the accumulation of ...
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Isolation and Characterization of Clinical Triazole Resistance Aspergillus fumigatus in Iran
... of azole agents and azole resistance is commonly due to mutations in the cyp51A gene (12, ...of azole resistance in Aspergillus ...
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