B, bradykinin
The bradykinin B<sub>2</sub> receptor induces multiple cellular responses leading to the proliferation of human renal carcinoma cell lines
... Figure 6 NHE activity is required for bradykinin-induced ERK activation. Notes: (A) BK-induced NHE activity does not require ERK activation. Cells were pretreated with either 10 µM of an MEK inhibitor (PD98059) or ...
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Guanosine 3',5' monophosphate and adenosine 3',5' monophosphate content of human umbilical artery
... (b) Bradykinin, histamine, serotonin, acetylcholine, and K+ ion, which cause umbilical artery constriction, can increase the cGMP content of the artery segments within 30 s of exposure without altering the ...
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Novel signaling of dynorphin at κ opioid receptor/bradykinin B2 receptor heterodimers
... Fig. 2 Heterodimerization of KOR and B2R determined by BRET assays in living cells. (A) Heterodimerization of KOR and B2R was measured in the four indicated conditions by BRET. Twenty-four hours after transfection, the ...
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Effect of 3-substituted 1,4-benzodiazepin-2-ones on bradykinin-induced smooth muscle contraction
... of bradykinin and related kallidin is carried out in two ways: in- travascularly in plasma and extravascularly in tis - ...to bradykinin and kallidin producing which act preferentially on B 2 ...
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The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury
... (7): B H Sharma; NSCB Medical College, India (7): Y R Yadav; Tartu Univer- sity Hospital, Estonia (6): Toomas Asser; Sint-Vincentiushospital, Belgium (2): Patrick Druwé; Hospital Universitario Virgen del Rocio, ...
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Control of B2 bradykinin receptor gene expression
... The Na,K-ATPase is a p lasm a m em b ran e p ro te in containing two subunits, a large a catalytic su b u n it and a sm aller Ë subunit. The a subunit has three isoforms known as a l , a2 and a3. A 92bp ...
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ADRB2, ADRB3, BDKRB2 and MTNR1B Genes Related to Body fat Modulation and Its Interaction with Physical Activity and Blood Pressure
... Abbreviations ACE: Angiotensin-converting enzyme ADRB2 gene: Adrenoceptor beta 2, surface ADRB3 gene: Adrenoceptor beta 3 ANS: Autonomic nervous system BDKRB2 gene: Bradykinin receptor B[r] ...
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Cloning and regulation of the rat bradykinin B1 receptor gene
... (Dinarello and Krueger, 1986; Tiffany and Burch, 1989; Dinarello, 1992; Vassalli, 1992; Tsukagoshi et al, 1999). A central role for IL-1 was initially proposed to explain the action of diverse agents that can increase ...
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Hypoxia Impairs Vasodilation in the Lung
... II, bradykinin, or serotonin pressor ...serotonin, bradykinin, or KCl, (b) hypoxia slows vasodilation following KCl-induced vasoconstriction probably by altering lung handling ...
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Characterisation of the kinin receptor in the human nasal airway and its role in allergic rhinitis
... on bradykinin challenge suggesting that cholinergic pathways do not play a role in the nasal actions of bradykinin in normal non-atopic subjects (Rajakulasingam et a l, ...in bradykinin-mediated ...
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Chondrocyte responses to neurovascular peptides, cytokines, and a 3D environment: focus on ADAMs
... and bradykinin under normoxic conditions (red bars) and are maintained under hypoxic conditions ...and bradykinin under normoxic conditions (red) and overall responses are reduced under hypoxic conditions ...
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Bradykinin as a Probable Aspect in SARS-Cov-2 Scenarios: Is Bradykinin Sneaking out of Our Sight?
... The lungs express a high amount of ACE2 which may have a role in maintaining Ang II and Ang 1-7 balance. 17,18 Ang II exerts vasoconstriction effects during hypoxic conditions and evokes pulmonary edema by increasing ...
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The design and synthesis of non-peptide bradykinin B2 receptor antagonists
... Genentech scientists also used the same approach to design a non-peptide RGD mimetic^^’^®. They studied the ^H-nmr solution conformation of a rigid and potent peptide antagonist (G 4120) and, rather than use sequential ...
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Bradykinin increases resensitization of purinergic receptor signaling in glioma cells
... with bradykinin application was also preserved in 0 Ca 2+ medium, although a significantly smaller peak amplitude (39% average resensitization in 0 Ca 2+ ...
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Ecallantide is a novel treatment for attacks of hereditary angioedema due to C1 inhibitor deficiency
... Abstract: Hereditary angioedema (HAE) resulting from the deficiency of the C1 inhibitor protein is a rare disease, characterized by paroxysms of edema formation in the subcutis and in the submucosa. Edema can cause ...
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Endothelial and Smooth Muscle-Dependent Vascular Reactivity in Immature Arterialized Collateral Capillaries
... Bradykinin is an endothelial-dependent agonist that interacts with G protein coupled receptors (GPCR) at the endothelial cell surface [6]. The binding of BK to the GPCR activates phospholipase C (PLC) and causes ...
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Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies
... of bradykinin, which is hypothesized to accu- mulate excessively in some patients taking ACEI for their ...of bradykinin, on the other hand, occurs when complement-1 inhibitor (C1- INH) is either deficient ...
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Endothelium dependent hyperpolarization caused by bradykinin in human coronary arteries
... NLA, bradykinin evoked transient and concentration-dependent hyperpolarizations only in tissues with endothelium, which were augmented by perindoprilat and mimicked by the calcium ionophore ...
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* M. Himaja Trivedi, A. Saravana Kumar, S. Mohana Lakshmi
... Carrageenan-induced edema has been commonly used as an experimental animal model for acute inflammation and is believed to be biphasic. The early phase (1–2 h) of the carrageenan model is mainly mediated by histamine, ...
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In vivo bradykinin B2 receptor activation reduces renal fibrosis
... acute ureteral obstruction occurs in different kidney dis- eases at all ages. Most of the time it is congenital in new- borns or induced by trauma or prostatic hypertrophy in adults. Without an appropriate treatment, ...
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