B-cell Chronic Lymphocytic Leukemia
B-Cell Chronic Lymphocytic Leukemia with 11q22.3 Rearrangement in Patient with Chronic Myeloid Leukemia Treated with Imatinib
... diseases chronic myeloid leukemia (CML) and B-cell chronic lymphocytic leukemia (B-CLL) is a rare ...developed B-CLL with ...of B-CLL was ...
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Original Article CD317 is over-expressed in B-cell chronic lymphocytic leukemia, but not B-cell acute lymphoblastic leukemia
... mature B cells, we pro- cured healthy human bone marrow, and flow cytometry was used to determine the mean fluorescence intensity (MFI) of CD317 on vari- ous subsets of developing B ...
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Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells
... clonal expansion. In particular, AMPK activation opposes tumor progression in several cancer types [70] through inhibition of tumor growth-stimulating mammalian Target of Rapamycin (mTOR) [20], and to down-regulation of ...
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Alemtuzumab in the treatment of fludarabine refractory B-cell chronic lymphocytic leukemia (CLL)
... alemtuzumab 20 mg SC (Days 1–3). This combination was repeated on day 29 for up to 6 cycles. MRD was measured by 4-color fl ow cytometry and consensus primer PCR. Twenty- three patients were enrolled. The median age of ...
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Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia
... Chronic lymphocytic leukemia (CLL) is characterized by proliferation and accumulation of malignant B lympho- cytes in the peripheral lymphoid tissues and bone ...
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Development of plasma cell myeloma in a B cell chronic lymphocytic leukemia patient with chromosome 12 trisomy
... a B-CLL patient who developed a ...of B-CLL and PCM producing IgG1 kappa and IgA kappa, respectively ...the B-CLL cells and induced differentiation to plasma cells, which in turn produced IgG and ...
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Case report: rare case of infiltration of small lymphocytic B-cell lymphoma in the thyroid gland of female patient with B-cell chronic lymphocytic leukemia (CLL-B/SLL-B)
... cases also surgery and immunochemotherapy with mono- clonal antibodies. Our patient did not respond to chemo- therapy and progression of the disease was observed during treatment. Because of genetic background of the ...
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Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients
... with B cell chronic lymphocytic leukemia (B-CLL) can be predicted by analysis of muta- tions in the immunoglobulin heavy chain variable gene ...UM B-CLL patients with ...
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Histiocytic Sarcoma in a 3-Year-Old Male: A Case Report
... (B-cell chronic lymphocytic leukemia/lymphoproliferative dis- ease marker), CD21 (mature B-cell and follicular dendritic cell marker), CD35 (follicular dendritic ...
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Combination of BCL11A siRNA with vincristine increases the apoptosis of SUDHL6 cells
... B cell chronic lymphocytic leukemia/lymphoma 11 (BCL11) gene family members, including the BCL11A and BCL11B, have been identified as transcriptional repressors, which are essential for ...
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Multicomponent analysis of amino acid transport in human lymphocytes Diminished L system transport in chronic leukemic B lymphocytes
... in B cell chronic lymphocytic leukemia and compared it with the amino acid transport in isolated B lymphocytes from human blood and ...in chronic lymphocytic ...
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Residual normal B-cell profiles in monoclonal B-cell lymphocytosis versus chronic lymphocytic leukemia
... of B-cell responses driven by newly encountered Ags from MBL lo to MBL hi and ...pre-GC B-cell production, that would lead to a progressively reduced B-cell repertoire, with ...
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Intraclonal Cell Expansion and Selection Driven by B Cell Receptor in Chronic Lymphocytic Leukemia
... by chronic lymphocytic leukemia (CLL) clones defines two disease ...identical B cell receptors (BcR), often encoded by the same IG ...normal B cells together with the expression ...
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B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292
... Abstract: Chronic lymphocytic leukemia (CLL) is the most common adult ...the B cell receptor (BCR) pathway in CLL have led to the development of a number of agents targeting this ...
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Idelalisib therapy of indolent B-cell malignancies: chronic lymphocytic leukemia and small lymphocytic or follicular lymphomas
... of B-cell malignancies on the B-cell receptor (BCR) signaling path- way has led to the development of novel orally-bioavailable small-molecule inhibitors of several kinases downstream of the ...
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Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6–deficient process
... leukemic B cell expression of ligands that trigger T cell inhibitory receptors ...T cell compartment is clearly functional, at least with regard to facilitating B cell ...
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Original Article Metadherin contribute to BCR signaling in chronic lymphocytic leukemia
... Chronic lymphocytic leukemia (CLL) is charac- terize by the accumulation of abnormal mono- clonal, mature B cells in peripheral blood, bone marrow, lymph node, spleen, liver and other organs ...
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Refractory chronic lymphocytic leukemia – new therapeutic strategies
... of chronic lymphocytic leukemia (CLL) has considerably improved since the introduction of fludarabine (F) as part of the standard ...Further B-cell antigens are targeted by lumiliximab ...
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High rates of submicroscopic aberrations in karyotypically normal acute lymphoblastic leukemia
... lymphoblastic leukemia; aMCB: Array-proven multicolor-banding; AML: Acute myelogenous leukemia; BAC: Bacterial artificial chromosome; B-ALL: B-cell ALL; Bp: Basepairs; CLL: ...
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High levels of circulating soluble receptors for tumor necrosis factor in hairy cell leukemia and type B chronic lymphocytic leukemia
... and B titers were found to be elevated in almost all sera obtained from patients with underlying malignant ...with B cell malignancies including hairy cell leukemia (HCL) and type ...
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