B cell depletion
Preemptive CD20+ B cell depletion attenuates cardiac allograft vasculopathy in cyclosporine treated monkeys
... B cell depletion in blood after αCD20 ...T cell counts at day 14 in association with acute parvo- virus infection was censored from this ...blood B cells are efficiently depleted for ...
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B-Cell Depletion for Autoimmune Thrombocytopenia and Autoimmune Hemolytic Anemia in Pediatric Systemic Lupus Erythematosus
... the B-cell depletion and resulting hypogammaglobulinemia, there were no infections that required hospitalization or the use of antibacterial, antifungal, or antiviral ...
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B cell depletion in SLE: clinical and trial experience with rituximab and ocrelizumaband implications for study design
... from B- cell depletion, and again suggest there is much work to be done to understand lupus disease and factors that may infl uence the design, population and, ultimately, the outcome of clinical ...
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The mechanism of anti CD20–mediated B cell depletion revealed by intravital imaging
... for B cell depletion through Ab-dependent cellular ...Ab-coated B cells ...the depletion mechanism or whether KCs were simply scavenging dead cells previously killed by other effec- ...
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Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disorders
... pathogenic B-cell properties, substantial interest has developed for testing anti-CD20 antibodies (rituximab, ocrelizumab, ofatumumab) in MS and ...mature B-cells, but spare CD20-negative plasma ...
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B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors
... T cell-mediated, some irAEs such as select endocrinopathies, autoimmune hemolytic anemia (AIHA), bullous skin eruptions and some neurologic tox- icities appear to be more specifically mediated by B cells ...
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B cell depletion in autoimmune disease
... immature B and mature B cells); this gives rise to plasma cells, which produce ...cells, B cells, cytokines and other elements within the immune system has been debated for decades, but the past 5 ...
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B cell depletion in immune thrombocytopenia reveals splenic long lived plasma cells
... a B cell–depleting agent, has become the first-line treatment for ITP; however, patients with refractory disease usually require ...splenic B cell population that is resistant to ...by ...
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Induction of long term B cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity
... continuous B-cell depletion on (auto)antibody secretion derived from mature, presumably long-lived plasma cells, we intended to further illustrate this observation by estimat- ing the survival of ...
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Class switched B cells display response to therapeutic B cell depletion in rheumatoid arthritis
... repetitive B-cell depletion courses appear safe in RA [11,12], but the risk of secondary immunodeficiency with more repetitive RTX courses is still not ruled ...on B-cell kinetics ...
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B cell depletion in autoimmune diabetes:insights from murine models
... of B cells in mediating various types of autoimmune ...to B-cell-expressed CD20 and mediates destruction by antibody-dependent cellular cytotoxicity utilising Fcγ receptors (FcγR) ...the B ...
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Autoantibody-producing plasmablasts after B cell depletion identified in muscle-specific kinase myasthenia gravis
... to depletion and mount robust recall responses ...of B cells that were present prior to ...nascent B cell responses have been proposed for IgG4-related disease ...Large-scale B ...
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Regeneration of the immunoglobulin heavy chain repertoire after transient B cell depletion with an anti CD20 antibody
... Our study was not designed to detect specific disease-rele- vant changes in the repertoire. However, in addition to the treatment-induced reduction in disease activity, a specific decline in RF activity was observed. The ...
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B cell depletion: a novel therapy for autoimmune diabetes?
... However, B cells have been implicated in the pathogenesis of the disease in NOD ...induce B cell depletion in mice, a clinical trial using the B cell–depleting anti-CD20 ...
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Original Article Characterization of the B cell response to Leishmania infection after anti-CD20 B cell depletion
... induce B-cell depletion for 6 to 9 months, their immunoglob- ulin levels do not decrease ...memory B cell population [8]. Therefore, most patients receiving B-cell ...
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Monitoring of Immune Cell Response to B Cell Depletion Therapy and Nerve Root Injury Using Spio Enhanced MRI
... this cell type plays in marshaling the body’s defenses has made it attractive as a means to augment the native immune response against malignancies ...dendritic cell-based ...5 cell with the high ...
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Update on the use of rituximab for intractable rheumatoid arthritis
... between B cell depletion and clinical efficacy? Circulating memory B cells and plasmablasts are associated with relapse and ...memory B cells and plasmablasts are generated in the ...
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PD L1(hi) B cells are critical regulators of humoral immunity
... hi B cells. Despite efficient B-cell depletion in mice, PD-L1 hi B cells were refractory to ...that B-cell depletion in lymphoma left endogenous IL-10- producing ...
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Regulatory B cell production of IL 10 inhibits lymphoma depletion during CD20 immunotherapy in mice
... a B cell phenotype, and almost all express cell surface CD20 ...circulating B cells, these only represent approximately 2% of all B ...tissue B cell depletion are ...
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NK cell count as predictor of clinical response in patients with rheumatoid arthritis treated with rituximab
... and B cell depletion, rheumatoid factor titer in RA, or lowering titers of anti-double-stranded DNA antibodies for lupus patients and, thus, research in rituximab therapy in autoimmune diseases ...
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