B-cell receptor
B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling
... in B-lymphomagenesis is based largely on the discovery of Pax5-specific translocations and somatic hypermutations in non- Hodgkin ...mouse B lymphoma cell lines, Myc5- M5 and Myc5-M12, which ...
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CD19 is a major B cell receptor–independent activator of MYC driven B lymphomagenesis
... a B cell–specific transcription factor, is overexpressed through chromosomal translocations in a sub- set of B cell ...and B cell receptor (BCR) signaling by PAX5 ...
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B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice
... During B lymphocyte development in the BM, immature B cells expressing self-reactive antigen receptors are tolerized by a vari- ety of ...purges B cells reactive to self antigens from the repertoire ...
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Studies on the role of the tyrosine kinase Lyn in B cell receptor signal transduction
... the B cell receptor (Gold, M atsuuchi et ...developing B cells at different stages of ...probe B cell ...recovered b ound to Ig a b u t n o t Igp, w hilst the 85kD ...
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Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development
... Developing B cells must pass a series of checkpoints that are regulated by membrane- bound Igµ through the Iga-Igb signal ...affects B cell development and Ab selection in humans we analyzed Ig gene ...
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B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292
... Abstract: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The current treatment paradigm involves the use of chemoimmunotherapy, when patients develop an indication for therapy. With this strategy, ...
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Practical guidelines for B-cell receptor repertoire sequencing analysis
... of B-cell immunoglobulin repertoires is increasingly being applied to gain insights into the adaptive immune response in healthy individuals and in those with a wide range of ...for B-cell ...
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B cell receptor apoptosis: signalling and regulation
... Initial research showed that mIg and CD79a do not associate with lipid rafts in untreated resting B cells, but that mAb receptor cross-linking caused translocation of mIg along with CD79[r] ...
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Intraclonal Cell Expansion and Selection Driven by B Cell Receptor in Chronic Lymphocytic Leukemia
... identical B cell receptors (BcR), often encoded by the same IG ...normal B cells together with the expression of stereotyped receptors by unmutated CLL clones may indicate stimula- tion/selection by ...
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Racial differences in B cell receptor signaling pathway activation
... in B cell subset frequencies and BCR-mediated signaling pathway activation were found amongst AA and EA ...in B cell subpopulation frequencies and BCR signaling in additional ethnic ...immune ...
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Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma
... Upon antigen engagement, Igα–Igβ heterodimer (CD79a-CD79b) are phosphorylated on immunoreceptor tyrosine-based activation motif (ITAM) tyrosines by the BCR-associated kinase LYN, which belongs to the Src family kinases ...
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Targeting CD22 with the monoclonal antibody epratuzumab modulates human B cell maturation and cytokine production in response to Toll like receptor 7 (TLR7) and B cell receptor (BCR) signaling
... protocol. Cell suspen- sions were prepared by gently teasing tissues in R10 medium (RPMI 1640 containing 10% FBS (ThermoFisher Scientific), 100 U/ml penicillin, 100 mg/ml streptomycin, 2 mM L -glutamine, 1 mM ...
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B-cell receptor-guided delivery of peptide-siRNA complex for B-cell lymphoma therapy
... and B, sample 0) or to cells treated at zero time, that showed fluores- cent values similar to those of untreated samples (not shown), both peptide-siRNA complexes were able to delivery siRNA in A20 cells with ...
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CD5 Is Dissociated from the B-Cell Receptor in B Cells from Bovine Leukemia Virus-Infected, Persistently Lymphocytotic Cattle: Consequences to B-Cell Receptor-Mediated Apoptosis
... and B, apoptosis was increased in control group IV, in which cells from PL animals were not treated with antibody to the ...PL B cells but not in B cells from uninfected ...of B cells ...
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NF-κB signaling and its relevance to the treatment of mantle cell lymphoma
... Activated B cell-like diffuse large B cell lymphoma; BAFF/ TNFSF13B: B cell-activating factor; BAFFR: B cell-activating factor receptor; BCAP: B ...
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Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
... β cell dys- function (Supplemental Table ...distinct receptor distributions among various ...T cell receptor β chain (TRB) and B cell receptor (BCR) immunoglobulin heavy ...
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Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in tourette syndrome: a pilot study
... included B cell development, antigen presentation pathway, cardiac β-adrenergic signaling, B cell receptor signaling, primary immunodeficiency sig- naling and GM-CSF signaling (Table 1, ...
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Analysis of Host Gene Expression Changes Reveals Distinct Roles for the Cytoplasmic Domain of the Epstein-Barr Virus Receptor/CD21 in B-Cell Maturation, Activation, and Initiation of Virus Infection
... the B-cell receptor (BCR) or triggered immediately prior to BCR cross-linking, toggling of CD21 (a surrogate for immune com- plex interaction) amplifies mIg signaling, B-cell ...
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Peripheral regulatory cells immunophenotyping in Primary Sjögren's Syndrome: a cross sectional study
... BAFF: B cell activating factor; BCR: B cell receptor; CpG: cytosine-phopsphate-guanosine; DC: dendritic cell; DCregs: indoleamine 2,3-dioxygenase-expressing dendritic cells; ...
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Surface receptor Toso controls B cell–mediated regulation of T cell immunity
... the cell surface receptor Toso on B cells unexpectedly resulted in impaired proinflammatory T cell responses, which led to impaired immune protection in an acute viral infection model and was ...
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