B-cell receptor signaling
Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study
... Conspicuously B cell receptor signaling which is enriched in our genetic network is also downstream to both of the ...kinase signaling (MAPK), phosphatidylinositol-3 kinase and protein ...
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Racial differences in B cell receptor signaling pathway activation
... Seven signaling nodes (anti-IgD ! p-S6, anti-IgD ! p- Syk, anti-IgD ! p-Akt, anti-IgD ! p-Erk, anti-IgD ! p- SFK, anti-IgD ! p-p38, and anti-IgD ! p-NF-κB), or specific protein readouts of modulated ...
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Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma
... Upon antigen engagement, Igα–Igβ heterodimer (CD79a-CD79b) are phosphorylated on immunoreceptor tyrosine-based activation motif (ITAM) tyrosines by the BCR-associated kinase LYN, which belongs to the Src family kinases ...
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B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling
... of B cell receptor (BCR) signaling, including CD79a, a protein with the immunoreceptor tyro- sine-based activation motif ...BCR/ITAM signaling in Pax5-dependent lymphomagenesis was ...
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Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in tourette syndrome: a pilot study
... included B cell development, antigen presentation pathway, cardiac β-adrenergic signaling, B cell receptor signaling, primary immunodeficiency sig- naling and GM-CSF ...
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NF-κB signaling and its relevance to the treatment of mantle cell lymphoma
... targeting B cell receptor signaling in MCL cells, which indirectly reduces canonical NF-κB ...non-canonical signaling and cross-talk with other pathways, such as the PI3K/Akt pathway to ...
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Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation
... These results parallel values reported in the literature for inhibition of BTK, PI3K ␦ , and LYN enzymatic activities (8–10). As shown in Fig. 2B, these agents block anti-Ig-induced phosphorylation of downstream B ...
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Viral Modulation of T-Cell Receptor Signaling
... infects B lymphocytes, in which it establishes latency and induces alterations in B-cell receptor ...TcR signaling in EBV-infected T cells is disrupted via the action of the latent ...
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Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
... response, B cell receptor signaling pathway, G-protein coupled purinergic nucle- otide receptor signaling pathway, regulation of immune response, ...nucleotide receptor ...
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B-cell receptor-guided delivery of peptide-siRNA complex for B-cell lymphoma therapy
... murine B lymphoma engrafted in syngenic, immune competent mice ...of receptor-mediated ...BCR-mediated signaling that induced apoptosis of the target ...
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CD95 Signaling Inhibits B Cell Receptor-Mediated Gammaherpesvirus Replication in Apoptosis-Resistant B Lymphoma Cells
... antiapoptotic signaling pathways, which might contribute to the survival of the CD95 apoptosis-resistant ... receptor knockout mice in vivo (46), we hypothesized that anti-CD95 agonist-in- duced IFN-  ...
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Syk inhibitors in clinical development for hematological malignancies
... of B-cell lymphoma cell ...blocked B-cell activation in a rat model and splenomeg- aly in a mouse model of chronic B-cell antigen receptor ...lymphoma cell ...
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Effects of vitamin D3 and its chemical analogs on the growth of Hodgkin’s lymphoma, in vitro
... D3 receptor signaling and its therapeutic per- turbation with vitamin D3 (VD3, 1,25-dihydroxyvitamin, calcitriol) or vitamin D3 analogs (VDAs) have attracted much attention in cancer therapies, including ...
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Toll-Like Receptor 9 and Interferon-Gamma Receptor Signaling Suppress the B Cell Fate of Uncommitted Progenitors in Mice
... of B cell lymphoma (BCL)-xL or BCL-2 transgenic mice the transgene under control of lymphoid restricted promoters should shed light on whether apoptosis is a main ...of cell divisions can then be ...
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Targeting CD22 with the monoclonal antibody epratuzumab modulates human B cell maturation and cytokine production in response to Toll like receptor 7 (TLR7) and B cell receptor (BCR) signaling
... protocol. Cell suspen- sions were prepared by gently teasing tissues in R10 medium (RPMI 1640 containing 10% FBS (ThermoFisher Scientific), 100 U/ml penicillin, 100 mg/ml streptomycin, 2 mM L -glutamine, 1 mM ...
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Epstein-Barr virus LMP2A signaling in statu nascendi mimics a B cell antigen receptor-like activation signal
... LMP2A signaling activates the EBV-encoded bzlf1 gene To assess further downstream responses as well as the functional significance of LMP2A-induced signals we monitored transcriptional activation of EBV-encoded ...
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Antigen receptor signaling in the rheumatic diseases
... TCR signaling in many ways, relying upon the ITAMs of the associated Igα and Igβ chains, the B-cell-expressed SFKs Lyn, Fyn, and Blk, and the Syk kinase as well as homologous adaptors (Blnk/Slp-65 ...
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Cell autonomous and cell non autonomous signaling through endothelin receptor B during melanocyte development
... a cell non- autonomous rescue of Ednrb-negative melanocyte precursors to the tyrosinase-positive stage, differentiation to mature, pigmented melanocytes was not observed, either in co-cultures or after the ...
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Heterogeneity of Toll like receptor 9 signaling in B cell malignancies and its potential therapeutic application
... cells, B-cell malignancies arising from different stages of B cell development also express TLR9 ...of B-cell malignancies are different from normal B cells ...malignant ...
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Original Article Pathway analysis of esophageal squamous cell carcinoma using iTRAQ-based quantitative proteomic approach
... Wnt signaling pathway also named the Wnt/β-catenin pathway was consid- ered as the most prevalent mechanism in the development of cancer, and its activation was a highly integrated process with complex multiple ...
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