B cell repertoire
B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation
... vaccine-specific repertoire yielded a number of interesting ...naïve repertoire, we sequenced only the class-switched IgG ...vaccine-specific repertoire, we also find sequences matching previously ...
13
Prolactin modulates the naive B cell repertoire
... both B and T cells express prolactin ...anti-DNA B cells in nonspontaneously autoimmune female BALB/c mice transgenic for the heavy chain of an anti-DNA ...ing B cells, elevated serum anti-DNA ...
10
Self-tolerance curtails the B cell repertoire to microbial epitopes
... F+S-reactive B cell populations normally removed or made infrequent by tolerance by the transient modulation of central or peripheral tolerance checkpoints in ways that maximize antibody responses to ...
18
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
... as B cells are thought to play a key role in antigen presen- ...of B cells that were isolated based on binding to an insulin antigen (IBC) adsorbent followed by single-cell sorting ...spleen B ...
20
Clonal expansion is a characteristic feature of the B cell repertoire of patients with rheumatoid arthritis
... of B-cell clonal diversity in patients with rheumatoid arthritis by using HCDR3 (third complementarity determining region of the rearranged heavy chain variable region gene) length as a ...from B ...
9
Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques
... specific B cells could be detected in all sampled tissues (Figure ...isolated B cells expressing V2 K169 antibodies that mediated tier 1 neutralization and bound infected cells, along with V3 and CD4 ...
18
B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue
... on B cell APC function (20, 35, ...anti-CD20 B cell–depleting monoclonal antibodies (37, 38), experimental and human evidence suggests that B cells within GCs in secondary and tertiary ...
19
Longitudinal analysis of the peripheral B cell repertoire reveals unique effects of immunization with a new influenza virus strain
... the repertoire in individuals with a history of exposure to different antigens), we identified consist- ent response patterns between both TIV (pre and post- pandemic) vaccines, that were clearly different to the ...
17
Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients
... related B cells are present in CSF and PB of MS patients (7, 8, ...between B cell subsets in untreated MS CSF and PB. In B cells, random somatic recombination of Ig germline genes (IGHV, IGHD, ...
17
Persistence and selection of an expanded B cell clone in the setting of rituximab therapy for Sjögren’s syndrome
... antibody repertoire, particularly in antigen- experienced B cells ...circulating repertoire of expanded B-cell clones in patients with primary SjS who did not have lymphoma or overt ...
13
Rhesus Macaque B Cell Responses to an HIV 1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis
... memory B-cell repertoire evolving toward GE143 driven by the HCDR3-mediated ...memory B cells, upon acquiring the GE143-like HCDR3s, as defined by the 95% cutoff, were no longer detectable in ...
17
Acquired immunity: immunosenescence and physical activity
... of B- cell clonal expansion, which not only limits the diversity of the B-cell repertoire but likely induces monoclonal serum immunoglobulins and B-cell neoplasm [39, ...
8
Regeneration of the immunoglobulin heavy chain repertoire after transient B cell depletion with an anti CD20 antibody
... The B-cell repertoire is shaped by a complex set of gene rear- rangements, somatic hypermutation and receptor-driven ...[7]. B cells develop in the bone marrow and in the foetal liver, and ...
11
B cells in rheumatoid arthritis
... follicular B cells (Table 1) that express a GC phenotype was iso- lated directly from frozen tissue sections, DNA was pre- pared, and the rearranged V-region genes were amplified, cloned and sequenced ...of ...
6
Upbeat and quirky with a bit of a build: Interpretive repertories in creative music search
... switching repertoire and acknowledging the existence of more than one point of ...or repertoire, positions music differently in a users’ world ...Musical Repertoire, the Business Repertoire, ...
7
The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age
... memory B cells, which are all antigen-experienced cells though arising via distinct acti- vation ...memory B cell populations are so small that they can only be sorted from buffy coats of healthy ...
12
Immunoprevalence and Immunodominance of HLA-Cw∗0801-Restricted T Cell Response Targeting the Hepatitis B Virus Envelope Transmembrane Region
... T cell responses in HIV infections was extended to Asian popula- tions, where it was shown that the high expression of HLA-C mol- ecules results in a stronger HLA-C-restricted HIV-specific im- mune response and an ...
10
Specific T cell activation in an unspecific T cell repertoire
... blood cell that circulate around our bodies, scan- ning for cellular abnormalities and ...TCR repertoire, despite its limited numerical di- versity, the flexibility to respond to almost any antigenic ...
29
Mechanisms of B cell autoimmunity in SLE
... autoreactive B cells after GC ...memory B cells that emerge from ...autoreactive B cells comes from a study showing that B cells expressing the anti-DNA encoding 9G4 idiotype were detectable ...
12
Recall T cell responses to bluetongue virus produce a narrowing of the T cell repertoire
... To evaluate the immune response after primary and sec- ondary BTV infections, and according to the scheme indicated above, total PBMC were isolated from periph- eral blood and quantified at different times post-inocu- ...
12