B lymphoblastoid cell lines
Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency
... Circulating lymphocytes Enzyme activities nmol/ min/mg protein Fumarase Citrate synthase Citrate synthase/fumarase ratio B lymphoblastoid cell lines Enzyme activities nmol/ min/mg protei[r] ...
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Investigating remission and relapse in type 1 diabetes. Immune correlates of clinical outcome in beta-cell replacement therapies
... globulin; B-LCL: B-lymphoblastoid cell lines; CDC: complement-dependent cytotoxicity; CMV: Cytomegalovirus; CNI: calcineurin inhibitors; CsA: cyclosporine A, CTL: cytotoxic T ...
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Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice
... human B lymphocytes following retroviral-mediated transduction rendered these cells highly tumorigenic in athymic ...The lymphoblastoid cells expressing IL-6 were indistinguishable from parental cell ...
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De novo synthesis and secretion of a 36 kD protein by cells that form lupus inclusions in response to alpha interferon
... two cell lines among 19 human lymphoblastoid cell lines tested that formed the human lupus inclusions (LI) to a high ...other cell lines were examined for protein changes ...
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Lymphoblastoid cell lines: a continuous in vitro source of cells to study carcinogen sensitivity and DNA repair
... of Lymphoblastoid cell lines (LCLs) as a surrogate for isolated or cryopreserved peripheral blood lymphocytes has substantially accelerated the process of biological ...resting B cells from ...
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Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen dependent T cell leukemia 1A (TCL1A) gene mediated regulation of cytokine expression
... Introduction: Arthralgias and myalgias are major side effects associated with aromatase inhibitor (AI) therapy of breast cancer. In a recent genome-wide association study, we identified SNPs - including one that created ...
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Epstein-Barr Virus Induces Adhesion Receptor CD226 (DNAM-1) Expression during Primary B-Cell Transformation into Lymphoblastoid Cell Lines
... LCL lines, sgCD226-1 and -2 ...LCL lines displayed reduced mRNA, due to nonsense-mediated decay, and lower surface expression of CD226 relative to an LCL control expressing an sgRNA targeting the AAVS1 AAV ...
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Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines
... The bone marrow-derived (B) lymphocyte can be identified by the presence of easily detectable surface immunoglobulin and a receptor for antigen-antibody-complement complexes (EAC¢). Monocytes and macrophages also ...
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TRAF1 Is a Critical Regulator of JNK Signaling by the TRAF-Binding Domain of the Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1 but Not CD40
... epithelial cell lines and COS-1 fibroblasts ...in cell extracts isolated from the EBV-negative B-cell lines Ramos, DG75, and BJAB and the EBV-positive lymphoblastoid ...
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A Study of Using Lymphoblastoid Cell Lines in Pharmacogenomics and Drug Family Clustering.
... Panels B and C are power curves for simulation where differences between genotypes are due to the distribution of the hill slope parameters “IC50” and “slope”, (using equally spaced drug dosages and a MAF of ...
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Infection of Lymphoblastoid Cell Lines by Kaposi's Sarcoma-Associated Herpesvirus: Critical Role of Cell-Associated Virus
... lymphoid cell lines for infectibility by ...(KSHV-negative B cell lines), BCBL1 and JSC1 (KSHV-positive PEL lines), and Jurkat and SupT1 (T cell ...recipient lines ...
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Induction of epstein-barr virus (EBV) lytic cycle in vitro causes lipid peroxidation, protein oxidation and DNA damage in lymphoblastoid B cell lines
... DNA fragmentation was detected in B95-8 and Raji cell lines after EBV lytic cycle induction as compared to controls. In fact, DNA damage is described in biopsies nasopharyngeal carcinoma patients [42], ...
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Regulation of EBNA gene transcription in lymphoblastoid cell lines: characterization of sequences downstream of BCR2 (Cp).
... of B lymphocytes in vitro, six EBV nuclear antigens (EBNAs) are expressed from one of two promoters, Cp and Wp, whose activities are mutually ...two lymphoblastoid cell ...
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Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines
... diseases. Lymphoblastoid B-cell lines (LCLs) are stable peripheral B-cell lines that are transformed by infection with Epstein-Barr virus ...of cell lines ...
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Limitations of lymphoblastoid cell lines for functional analysis of SNPs
... the cell lines showed comparable mean methylation (data not ...NF-kappa B consensus sequence has been predicted in the negative regulatory region ...various cell lines and therefore we ...
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Autoantibodies to B Lymphocytes in a Patient with Hypoimmunoglobulinemia: CHARACTERIZATION AND PATHOGENIC ROLE
... several lymphoblastoid cell lines and lymphocytes from immunodeficiency patients showed that these antibodies reacted with B ...stimulated B cells appear to lose this ...from ...
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Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines
... basal cell growth rate, have been described as potential confounding factors influencing the LCL drug response phenotype ...the cell line can alter growth ...of B-95 EBV-expressing marmoset ...
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Glycoprotein 110, the Epstein-Barr virus homolog of herpes simplex virus glycoprotein B, is essential for Epstein-Barr virus replication in vivo.
... formed lymphoblastoid cell line (19), M12, a murine B-lym- phocyte line (15), BJAB, and EBV-negative Burkitt’s lym- phoma cell line (23), or in reaction mixtures containing primers only ...
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The Switch from Latent to Productive Infection in Epstein-Barr Virus-Infected B Cells Is Associated with Sensitization to NK Cell Killing
... infected cell surface (58) to engage CD94/NKG2A inhibitory NK receptors ...of cell surface HLA class I molecules in the lytic ...NK cell receptors NKG2D (49) and DNAM-1 (9), ...NK cell ligands ...
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Transcript Isoform Variation Associated with Cytosine Modification in Human Lymphoblastoid Cell Lines
... ABSTRACT Cytosine modification on DNA is variable among individuals, which could correlate with gene expression variation. The effect of cytosine modification on interindividual transcript isoform variation (TIV), however, ...
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