B-lymphocyte stimulator
B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels
... Considerable evidence points to a role for B lymphocyte stimulator (BLyS) overproduction in murine and human systemic lupus erythematosus (SLE). Nevertheless, the correlation between circulating ...
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B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus
... 12]. B lymphocyte stimulator (BLyS)—also named B cell activating factor (BAFF)— is a B cell survival factor which increases in the serum of SLE patients and correlates with disease ac- ...
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The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
... tive B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a solu- ble ligand of the TNF cytokine family, is a prominent factor in B cell ...
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Biologic activity and safety of belimumab, a neutralizing anti B lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus
... Therefore, B-cell and plasma cell depletion may be an appropriate therapeutic approach in the treatment of ...SLE. B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ...
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Enhanced immunogenicity of pneumococcal surface adhesin A (PsaA) in mice via fusion to recombinant human B lymphocyte stimulator (BLyS)
... on B and T cells through which BLyS exerts its co-stimulatory effects [19,32], while TACI has been shown to be dispensable for the proliferation of purified B cells in response to stimulation with BLyS and ...
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B lymphocyte stimulator/a proliferation inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B cell maturation antigen immunoglobulin
... the B cell-expressed recep- tors transmembrane activator and CAML interactor (TACI), B cell-maturation antigen (BCMA), and BAFF receptor (BAFF-R), whereas APRIL homotrimers bind to TACI, BCMA, and ...
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Garden of therapeutic delights: new targets in rheumatic diseases
... Advances in our understanding of the cellular and molecular mecha- nisms in rheumatic disease fostered the advent of the targeted therapeutics era. Intense research activity continues to increase the number of potential ...
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New treatment options for lupus – a focus on belimumab
... on B lymphocytes (Figure 1): BLyS receptor 3 (BR3 or BAFF-R), transmembrane activator-1, calcium modulator and cyclophilin ligand-interactor (TACI), and B-B-lymphocyte stimulator cell ...
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Biologic therapy for autoimmune diseases: an update
... BLySS: B lymphocyte stimulator; BILAG: British Isles Lupus Assessment Group; CRP: C-reactive protein; DAS28: 28-item Disease Activity Score; DMARD: Disease-modifying anti-rheumatic drug; EC50: ...
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Cytokine profiling in active and quiescent SLE reveals distinct patient subpopulations
... IFNα, B lymphocyte stimulator (BLyS), IL-10, IL-17, IL-18, IL-21, C-X-C motif chemokine ligand (CXCL10), CXCL13, monocyte chemotactic protein-1 (MCP-1) and pentraxin related protein 3 ...PTX3), ...
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Ultrasonographic assessment of bone erosions in the different subtypes of systemic lupus erythematosus arthritis: comparison with computed tomography
... BLyS: B-lymphocyte stimulator; CD20: Cluster differentiation 20; CI: Confidence interval; CT: Computed tomography; CTL4: Cytotoxic T-lymphocyte antigen 4; ELISA: Enzyme-linked immunosorbent ...
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Trafficking of adoptively transferred B lymphocytes in B lymphocyte deficient mice
... of B cells (35 %) migrated to the draining popliteal LN nearest to the B-cell injection site within 1 day of subcutaneous injection and remained there for the first 3 ...of B cells (2.4 %) was ...
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Profile of atacicept and its potential in the treatment of systemic lupus erythematosus
... of B cell activating factors in the generation of autoantibodies in patients with systemic lupus erythematosus (SLE) is now ...regulate B cell maturation, function and ...
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Corruption of Human Follicular B-Lymphocyte Trafficking by a B-Cell Superantigen
... culturing B cells for 2 h in medium alone or in the presence of 10 µ g/mL Mod-SpA or 100 ng/mL ...culturing B cells for 16 h in medium alone or in the presence of 10 µ g/mL Mod-SpA or 10 µ g/mL anti-IgM Ab, ...
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Regulation of human aortic endothelial cell derived mesenchymal growth factors by allogeneic lymphocytes in vitro A potential mechanism for cardiac allograft vasculopathy
... HAEC- lymphocyte co-cultures were assessed for (a) lymphocyte proliferation in response to the allogeneic HAECs; (b) release of soluble factors that stimulate human aortic ...
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Kitasato symposium 2010: new prospects for cytokines
... Warren Leonard (Bethesda, MD, USA) reviewed the evidence that IL-21 is critical to the development of certain autoimmune diseases, including type I diabetes and SLE, but may also have therapeutic utility for cancer ...
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Prognostic performance of lymphocyte-to-monocyte ratio in diffuse large B-cell lymphoma: an updated meta-analysis of eleven reports
... carried out in the databases of PubMed and Web of Science to evaluate the association of LMR with the clinical prognosis of patients with DLBCL (updated on October 20, 2015). The following keywords are used, including ...
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Pleural effusion as an initial manifestation in a patient with primary pulmonary monoclonal B-cell lymphocyte proliferative disease
... Fig. 1 Chest CT scan in the axial plane performed 2 months following onset of symptoms showing (a) a nodule in the left lower lobe; the patient was administered fluconazole regularly for 4 months, and a repeated CT scan ...
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Mesenchymal lineage cells and their importance in B lymphocyte niches
... the B lymphocyte lineage, influencing both commitment to the B lymphocyte lineage and the progression of the immature B cells through the early stages of B ...in B ...
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Characterization of a non T, non B human lymphocyte (L cell) with use of monoclonal antibodies Its regulatory role in B lymphocyte function
... These studies investigate the role of L lymphocytes in regulating terminal B lymphocyte differentiation. L cells have abundant Fc IgG receptors and comprise 10--15% of human peripheral blood mononuclear ...
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