B lymphocyte stimulator (BLyS)
B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels
... for B lymphocyte stimulator (BLyS) overproduction in murine and human systemic lupus erythematosus ...of BLyS protein and disease activity in human SLE is modest at ...endogenous ...
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The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
... tive B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a solu- ble ligand of the TNF cytokine family, is a prominent factor in B ...
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Biologic activity and safety of belimumab, a neutralizing anti B lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus
... Therefore, B-cell and plasma cell depletion may be an appropriate therapeutic approach in the treatment of ...SLE. B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis ...
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B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus
... 12]. B lymphocyte stimulator (BLyS)—also named B cell activating factor (BAFF)— is a B cell survival factor which increases in the serum of SLE patients and correlates with ...
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Enhanced immunogenicity of pneumococcal surface adhesin A (PsaA) in mice via fusion to recombinant human B lymphocyte stimulator (BLyS)
... for BLyS, BAFF-R has been identified as the main receptor on B and T cells through which BLyS exerts its co-stimulatory effects [19,32], while TACI has been shown to be dispensable for the ...
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B lymphocyte stimulator/a proliferation inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B cell maturation antigen immunoglobulin
... Recombinant BLyS/APRIL heterotrimers were produced by using a proprietary N - terminal trimerization domain ...of BLyS were made by overlap polymerase chain reaction (PCR) of human APRIL [amino acids ...
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BLyS and APRIL in rheumatoid arthritis
... cytokines B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) enhance autoimmune disease by sustaining B cell ...RA, B cells contribute to the formation of ...
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APRIL, a proliferation inducing ligand, as a potential marker of lupus nephritis
... B lymphocyte stimulator (BLyS) and a proliferation- inducing ligand (APRIL) are associated with mechanisms of ...activate B cells and plasma cells to proliferate, differentiate and ...
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Garden of therapeutic delights: new targets in rheumatic diseases
... Advances in our understanding of the cellular and molecular mecha- nisms in rheumatic disease fostered the advent of the targeted therapeutics era. Intense research activity continues to increase the number of potential ...
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Cytokine profiling in active and quiescent SLE reveals distinct patient subpopulations
... IFNα, B lymphocyte stimulator (BLyS), IL-10, IL-17, IL-18, IL-21, C-X-C motif chemokine ligand (CXCL10), CXCL13, monocyte chemotactic protein-1 (MCP-1) and pentraxin related protein 3 ...
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Ultrasonographic assessment of bone erosions in the different subtypes of systemic lupus erythematosus arthritis: comparison with computed tomography
... Rheumatology; BLyS: B-lymphocyte stimulator; CD20: Cluster differentiation 20; CI: Confidence interval; CT: Computed tomography; CTL4: Cytotoxic T-lymphocyte antigen 4; ELISA: ...
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New treatment options for lupus – a focus on belimumab
... membrane, BLyS becomes a soluble trimer that is a ligand for three receptors expressed primarily on B lymphocytes (Figure 1): BLyS receptor 3 (BR3 or BAFF-R), transmembrane activator-1, calcium ...
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Biologic therapy for autoimmune diseases: an update
... BLySS: B lymphocyte stimulator; BILAG: British Isles Lupus Assessment Group; CRP: C-reactive protein; DAS28: 28-item Disease Activity Score; DMARD: Disease-modifying anti-rheumatic drug; EC50: ...
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Suppressive effects of sodium fluoride on cultured splenic lymphocyte proliferation in mice
... of lymphocyte in G1 phase was significantly increased ...splenic lymphocyte proliferation, which is represented by reducing populations and activation of splenic T and B ...splenic lymphocyte ...
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Regulation of human aortic endothelial cell derived mesenchymal growth factors by allogeneic lymphocytes in vitro A potential mechanism for cardiac allograft vasculopathy
... HAEC- lymphocyte co-cultures were assessed for (a) lymphocyte proliferation in response to the allogeneic HAECs; (b) release of soluble factors that stimulate human aortic ...
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Trafficking of adoptively transferred B lymphocytes in B lymphocyte deficient mice
... of B cells (35 %) migrated to the draining popliteal LN nearest to the B-cell injection site within 1 day of subcutaneous injection and remained there for the first 3 ...of B cells (2.4 %) was ...
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T and B lymphocyte subpopulations
... be considered to be T cells; however, a small pro- portion of such rosette-forming cells also carry re- ceptors for the Fe portion of immunoglobulin, and those cells carrying both marker[r] ...
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Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren’s syndrome
... regulates B lymphocyte proliferation and ...autoreactive B cells, possibly as they pass through a critical tolerance checkpoint while maturing in the ...(MZ) B cell compartment, one of the ...
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Dynamic analysis of lymphocyte subsets of peripheral blood in patients with acute self limited hepatitis B
... Hepatitis B virus (HBV), complex immune responses could be caused, and cell-mediated immunity is an important factor to determine results of HBV infection ...of lymphocyte have different responses to viral ...
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T and B Lymphocyte Subpopulations in Children
... Children under 18 months of age were found to have a decreased percentage of E-bincling (T) lym- phocytes and an increased percentage of EAC-binding (B) lymphocytes compared to older chi[r] ...
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