B Raf(V600E)
Cutaneous adverse reactions in B-RAF positive metastatic melanoma following sequential treatment with B-RAF/MEK inhibitors and immune checkpoint blockade or vice versa. A single-institutional case-series
... the B-RAF gene with V600E accounting for 80 – 90% in this ...for B-RAF V600E mutated melano- mas involves using B-RAF inhibitors in conjunction with MEK inhibitors ...ing ...
9
B-Raf and the inhibitors: from bench to bedside
... Allele-specific PCR is another category of mutation detection methods with the advantage of mutant enrich- ment and high sensitivity. The goals of these methods are to increase sensitivity, specificity and to accurately ...
9
B Raf(V600E) and thrombospondin 1 promote thyroid cancer progression
... reported that plasma TSP-1 levels are higher in patients with advanced breast cancer vs. patients with early breast cancer, and these levels are significantly higher than in normal controls (29). TSP-1 is a potent ...
6
Suppression of B-Raf(V600E) cancers by MAPK hyper-activation
... protein kinase (AMPK) activators have indeed been reported to induce cellular growth arrest [19], implying their prospective use in suppressing B-Raf(V600E) cancers. MEDICA analogs consist of long-chain, ...
11
AurkA inhibitors enhance the effects of B RAF and MEK inhibitors in melanoma treatment
... the B-RAF gene, encoding for a serine-threonine kinase, have been ...a B-RAF V600E mutation constitutively activate the MAPK pathway, promoting cell proliferation and preventing apoptosis ...
9
Heme oxygenase 1 facilitates cell proliferation via the B-Raf-ERK signaling pathway in melanoma
... in B-RAF genes are common in ...that B-RAF is a critical gene in the development of endometriosis [10], and overexpression of wild-type B-Raf is one of the mechanisms underlying ...
12
Inactivation of Icmt inhibits transformation by oncogenic K Ras and B Raf
... wild-type B-Raf did not yield a transformed phe- notype (not shown). (b) Western blot with a B-Raf–specific mAb (F-7; Santa Cruz Biotechnology ...increased B-Raf expres- ...
13
AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2
... tissues. We noticed that the fold changes of AKT3 mRNA between normal vs. malignant prostate issues is small. However, protein is the actual players involved in most biological process. The IHC staining (Figure 2) ...
16
TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B Raf mutational status
... 22. Esteller M, Gonzalez S, Risques RA, Marcuello E, Mangues R, Germa JR, Herman JG, Capella G, Peinado MA: K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. J Clin Oncol 2001, 19:299-304. 23. ...
8
ERK/pERK expression and B raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics
... of B-raf and K-ras ...or B-raf -independent manner in a large subset of primary colon cancer ...of Raf were identified, including Sprouty and ...no B-raf or K-ras muta- ...
11
Treatment of B RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
... with B-RAF mutations and that this effect was dependent on upregulation and dephosphorylation of the proapoptotic, Bcl-2 homology 3–only (BH3-only) Bcl-2 family member ...the B-RAF mutant ...
10
Original Article Functional cross-talk between cAMP and ERK1/2 pathway promotes proliferation of somatotropinomas in a B-Raf and C-Raf dependent manner
... Both B-Raf and C-Raf are intricately involved in the cross-talk depending on cell-type specificity, however, it has not been illustrated in ...of B-Raf and C-Raf in the ...
13
A novel MCF-10A line allowing conditional oncogene expression in 3D culture
... oncogenic B-Raf V600E induces the epithelial-to-mesenchymal transition (EMT) of MCF- 10A cells and therefore, if expressed a priori, prevents acinar morphogenesis ...of B-Raf V600E would ...
13
Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, BMC D13, 221 84 Lund, Sweden
... Data were processed with Proteome Discoverer 2.3 (Thermo Fisher Scientific, San José, CA, USA) using the Sequest HT search engine. The search was performed against the Homo sapiens UniProt revised database (2018-10-01) ...
11
Computational Modelling, Synthesis and Biological Evaluation of Guanidinium like Derivatives as Protein Kinase Inhibitors for the Treatment of Cancer
... The importance of the conformation of the DFG motif within the Mg 2+ binding loop in the activation of kinases is well established and it is accepted that some known B-Raf mutations like V600E produce ...
362
B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells
... Here we show that a BRAFV600E melanoma cells are killed by vemurafenib, driving apoptosis, b BRAFV600E melanoma cells are neither more resistant nor sensitive to temozolomide/fotemustine[r] ...
14
Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway
... and B-Raf phosphorylation but had no effect on Ras ...the B-Raf-V600E ...the B-Raf-V600E ...of B-Raf-V600E, is highly effective against cancer cell lines that ...
12
Suspension state promotes metastasis of breast cancer cells by up-regulating cyclooxygenase-2
... cells; B-RAF: B-Raf proto-oncogene; CaN: calcineurin; COX-2: cyclooxygenase-2; CsA: cyclo- sporine A; CTCs: circulating tumor cells; CXB: celecoxib; CytoD: Cytochalasin D; DEGs: differen- ...
15
Comparative Docking Studies of Osthol Derivatives and Sorafenib on BRAF V599E Mutant Protein
... the B-raf protein, and so it is subjected to induced fit docking and it was compared with the existing drug ...with B-RAF proto-oncogene serine/threonine-protein kinase mutant ...
8
The promise of circulating tumor cell analysis in cancer management
... kinase B-Raf (BRAF) inhibitors, colorectal cancers patients treated with anti-EGFR antibodies and patients with gastroin- testinal stromal tumors during tyrosine-protein kinase Kit/alpha-type ...
10