B/sub 12/H/sub 12/
P2Y<sub>12 </sub>and P2Y<sub>13</sub> receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia
... IL-1 b , IL-6 and TNF- a and their release were regulated by P2Y 12 and P2Y 13 receptors in ADP b s-treated dorsal spinal cord microglia ...P2Y 12 and P2Y 13 receptors are likely to have an ...
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Antioxidative stress effects of vitamins C, E, and B<sub>12</sub>, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats
... Owing to the nature and solubility of the tested vitamins, an oil-in-water (o/w) emulsion was found to be a suitable carrier for the vitamins and their combination. All vitamins were prepared as o/w emulsions, using 10% ...
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<p>The serum concentration of vitamin B<sub>12</sub> as a biomarker of therapeutic response in tuberculosis patients with and without human immunodeficiency virus (HIV) infection</p>
... ment in TB patients might be due to the body reclaiming normal physiological function of the affected organs 33 and immune function improves by cleaning or a rapid drop in the bacterial load, which had been driving and ...
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Enhanced pharmacological activity of Vitamin B<sub>12</sub> and Penicillin as nanoparticles
... Vitamin B 12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological ...Vitamin B 12 were investigated using electron microscopy as well as dynamic light scat- ...
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P2Y<sub>12</sub> receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain
... Notes: (A) The staining of p-p38MAPK-IR cells has been carried out for the sham + DMSO, sham + MRS2395, cancer + DMSO, and cancer + MRS groups. It showed lighter staining of p-p38MAPK and more ramifications in sham ...
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<p>Vitamin B<sub>12</sub> Deficiency and Foot Ulcers in Type 2 Diabetes Mellitus: A Case–Control Study</p>
... The mean BMI of the cases was 28.9 (SD ±5.3), with a range of 16.9 – 44.4. The mean BMI of the controls was 28.8 (SD ±4.3), with a range of 18 – 40. More cases (90.8%) had poor glycemic control than controls (69.8%). The ...
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Reliability and validity of the Spanish version of the Child Health and Illness Profile (CHIP) Child-Edition, Parent Report Form (CHIP-CE/PRF)
... Construct validity was examined by determining whether parents perceived their child ’ s health in the pre- dicted directions according to a priori hypotheses. According to the literature review and previous hypoth- eses ...
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Aptamer-functionalized peptide H<sub>3</sub>CR<sub>5</sub>C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma
... method at the ratio of 1.5:1 showed an EE% of 33.12% (Figure 3A). To increase the EE%, we adopted active loading using (NH 4 ) 2 SO 4 by changing the pH of the rehydrating medium. These results suggest that the drug ...
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Adapting and Validating a Scale to Measure Sexual Stigma among Lesbian, Bisexual and Queer Women
... Results. We specified that items in the sexual stigma scale pertained to lesbian, bisexual and queer women as the prior scale referred to gay men. In the perceived stigma subscale, for several items we removed the ...
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No evidence for activation of T<sub>H</sub>1 or T<sub>H</sub>17 pathways in unstimulated peripheral blood mononuclear cells from children with β-cell autoimmunity or T1D
... In the group of at-risk individuals, ie, children with β -cell autoantibodies, a decreased expression of GATA-3 in PBMC was the only aberrancy found in comparison to healthy age-matched children. Inhibition of GATA-3 ...
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Preclinical studies of N<sub>3</sub>-O-toluyl-fluorouracil-loaded lipid-based nanosuspensions in H<sub>22</sub>-bearing mice
... were randomly assigned to one of two groups and injected intravenously through the tail vein with 5-FU (52 mg 5-FU/kg dose) or TFU-LNS (100 mg TFU/kg dose, equal molar amount of 5-FU as the 5-FU injection group). In each ...
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Drug-likeness approach of 2-aminopyrimidines as histamine H<sub>3</sub> receptor ligands
... 162.34; 149.29; 121.15; 114.51; 71.07; 70.48; 60.28; 52.62; 48.22; 45.41; 27.54; 26.11; 24.28 ppm. ESI MS: 426.8 (M + H) (100%). Anal Calc for C 23 H 35 N 7 O × HCl × H 2 O: C, 57.55; H, 7.98; ...
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The Evidence of Invalidation of the BH model at the GC and the Existence of Magnetic Monopoles
... to sub-mm wavelength band with power peaking around 10 12 Hz in the sub-mm band and the x-ray radiation near the GC are also essentially in agreement with the prediction of our model ( Peng and Chou ...
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Making It Happen: Training health-care providers in emergency obstetric and newborn care
... A sub-study will explore retention of knowledge and skills over time (12 months) at the health-care facility level; the availability of signal functions as well as maternal and newborn health (MNH) outcomes ...
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Effect of plant extracts on H<sub>2</sub>O<sub>2</sub>-induced inflammatory gene expression in macrophages
... cells induced the transcription of proinflammatory mediators, showing that this could be an applicable system by which to activate macrophages. Plant extracts from AL, CS, PG, and VM possess in vitro anti-inflammatory ...
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Bioinformatics Insights Into Microbial Xylanase Protein Sequences
... Xylanase from Fibrobacter succinogenes occupied distinct place in the phylogenetic tree. The major clusters I and II represented predominantly multiple strains of Paenibacillus polymyxa and Dictyoglomusthermophilum ...
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Anticonvulsant effects of isomeric nonimidazole histamine H<sub>3</sub> receptor antagonists
... of H 3 R ligand 4 was not abrogated when animals were pretreated with RAMH (10 mg/kg, IP) 15 minutes before PTZ challenge, demonstrating that other mechanisms might explain the anticonvulsant effect observed for 4 ...
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Débats. Compte Rendu in Extenso Des Séances. No. 12 A and No. 12 B. 17 Mai 1960 = Debates. Proceedings of the sessions No. 12 A and No. 12 B. 17 May 1960.
... Si nous estimons, nous, Monsieur Carboni, par un jugement politique dont nous sommes, en quelque sorte, les seuls maîtres, qu'il est nécessaire, pour aller à l'élection au suffrage unive[r] ...
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Overall labor efficiency study at manufacturing company
... electrical sub-sector is becoming one of the most important sectors in Perak as 5 over 10 of huge industries there involve a big contribution of the sector itself (Khairul, ...
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Microbiomes of Top and Sub Layers of Semi Arid Soils in North Eastern Nigeria Are Rich in Firmicutes and Proteobacteria with Surprisingly High Diversity of Rare Species
... Agricultural practices in this region may strongly influence the population of Proteobacteria as leguminous plants forms the dominant cultivated crops in the semi-arid region. Changes in vegetation as well as intensive ...
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