B16F10 melanoma
Pentoxifylline: A Potent Inhibitor of Angiogenesis via Blocking STAT3 Signaling in B16F10 Melanoma
... Recently, Niu and colleagues reported that constitutive activity of STAT3 up-regulates VEGF expression and tumor angiogenesis[46]. In hypoxic condition of solid tumors STAT3 stabilizes HIF 1α through delaying protein ...
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Original Article Low concentration of caffeine inhibits cell viability, migration and invasion, and induces cell apoptosis of B16F10 melanoma cells
... We further examined the molecular mecha- nisms of inhibitory and regulatory effects of caffeine on migration and invasion. It has been reported that BMPs are overexpressed in malig- nant melanoma and promotes cell ...
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Phytochemical capacity of Nitraria retusa leaves extracts inhibiting growth of melanoma cells and enhancing melanogenesis of B16F10 melanoma
... that melanoma population growth reduction was linked to differentiation processes detected by monitoring some specific markers like melanine ...of B16F10 melanoma ...
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The atypical pattern of cell death in B16F10 melanoma cells treated with TNP-470
... TNP-470 is a semisynthetic derivative of the fungal alkaloid fumagillin. Both substances possess anti-angiogenic properties and inhibit the proliferation of endothelial cells via the p53/p21 pathway [1, 2]. Having a ...
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Antimelanogenic activities of piperlongumine derived from Piper longum on murine B16F10 melanoma cells in vitro and zebrafish embryos in vivo: its molecular mode of depigmenting action
... murine B16F10 melanoma cells and zebrafish was investigated, and its mode of antimelanogenic action was elucidated using quantitative reverse transcription‑poly‑ merase chain ...in B16F10 ...
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Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells
... respectively, at 24 hours; (C) cells treated with EGCG-pNG for 24 hours expressed more green fluorescence than those treated with EGCG (magnification ×200). Depolarized mitochondria are indicated by green fluorescence ...
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Traditional herbal prescription LASAP C inhibits melanin synthesis in B16F10 melanoma cells and zebrafish
... ing B16F10 cells with LASAP-C (0, 10, 50, 100, 200, and 400 μg/mL) for 2 days and measuring the cell viability (data not ...The B16F10 cells retained ...in B16F10 melanoma cells compared to ...
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Chemopreventive Action of Lawsonia Inermis Leaf Extract on DMBA-Induced Skin Papilloma and B16F10 Melanoma Tumour
... The present investigation was undertaken to explore the antitumour activity of Lawsonia inermis leaf extract on DMBA induced 2-stage skin carcinogenesis and B16F10 melanoma tumour model. Topical single ...
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IN VIVO ANTITUMOR, ANTIOXIDANT ACTIVITIES AND TOXICITY PROFILE OF ETHYL ACETATE CRUDE LEAF EXTRACT OF PARKINSONIA ACULEATA L. (FABACEAE) ON B16F10 MELANOMA
... Melanoma is the deadliest form of skin cancer and any practical solution in combating this type of cancer is of paramount importance to public health. Because of various side effects of the allopathic drugs it is ...
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The synergistic influence of Holothuria arenicola extract and imidazole carboxamide on Cellosaurus cell line B16-F10
... accumulated in their epidermis (Bordbar et al., 2011). The existence of triterpenoid glycosides, chondroitin sulfates, glycosaminoglycan (GAGs), sulfated polysaccharides, sterols (glycosides and sulfates), phenol ...
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Evaluation of the Lobelia inflata Extract in the Histopathological Profile of Melanoma in Experimental Model
... of B16F10 melanoma cells, which is a well validated model for both primary tumor and we investigated the antitumoral activity of Lobelia inflata during melanoma ...
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Comparative analysis of cancer vaccine settings for the selection of an effective protocol in mice
... paper, we compare the protective efficacy of different pro- tocols of cancer vaccination based on a classical, widely adopted model system constituted by gp100 vaccination in B16F10 melanoma [27]. ...
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Melanogenesis Inhibitory Activity of Rhododendron Weyrichii in Mouse B16 Melanoma Cells
... Next, we explored the effects of the RW-H and RW-E extracts on a -MSH-induced melanin synthesis and tyrosinase activity. As shown in Fig. 3, cells treated with a -MSH alone had markedly increased melanin content compared ...
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Myocardin-related transcription factor A (MRTF-A) activity- dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity
... CA-MRTF-A-transfected B16F10 melanoma and a group of tumor cells exhibited prominent actin cytoskeletal and FA ...Since B16F10 cells were highly motile, possessed weakly detectable actin fibers, and ...
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Uptake of Cystatin by Melanoma Cells in Culture
... (Sigma-Aldrich) on a tube rotator for 1 hour at 4oC. Fol- lowing the reaction, the cystatin solution was dialyzed overnight against 1 liter of phosphate buffered saline (PBS) at 4˚C. B16F10 melanoma cells ...
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Original Article Expression of stabilin-1 in M2 macrophages in human granulomatous disease and melanocytic lesions
... a B16F10 melanoma in wild type mice stained positive; while staining of tumor-associated macrophages and vessels originating from stabilin-1 deficient mice remained negative for stabilin-1 specific antibody ...
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Inonotus Obliquus extracts as an inhibitor of α-MSH-induced melanogenesis in B16F10 mouse melanoma cells
... cultured B16F10 melanoma cells with α- MSH as a negative ...level. B16F10 cells treated with the Inonotus Obliquus extracts showed the cellular tyrosinase activity to be significantly decreased as ...
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Annona muricata L. extracts decrease melanogenesis in B16F10 mouse melanoma cells
... Herein, we investigated the effects of A. muricata L. extracts on melanogenesis and elucidated the ensuing mechanisms. Our experiments showed that treatment with A. muricata L. extracts decreases melanogenesis in a ...
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Anticancer effects of flavonoids on melanoma cells: are murine cells more sensitive compared to humans?
... Alcaraz M, Benavente-Garcia O, Castillo J, Lorente J, Lozano JA. Effects of several polyhydroxylated flavonoids on the growth of B16F10 melanoma and Melan-a melanocyte cell lines: influence of the ...
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Inhibition of melanogenesis by Gaillardia aristata flower extract
... in B16F10 cells was measured using the MTT assay. When B16F10 cells were treated with 0-50 μg/mL GAE no significant cytotoxic effect was evident ...in B16F10 melanoma ...cultured B16F10 ...
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