b5, cytochrome b5
Concentration of NADH cytochrome b5 reductase in erythrocytes of normal and methemoglobinemic individuals measured with a quantitative radioimmunoblotting assay
... The activity of NADH-cytochrome b5 reductase (NADH-methemoglobin reductase) is generally reduced in red cells of patients with recessive hereditary methemoglobinemia. To determine whether this lower ...
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Membrane bound cytochrome b5 reductase (methemoglobin reductase) in human erythrocytes Study in normal and methemoglobinemic subjects
... antigenically similar to the soluble enzyme. The two forms of enzyme are specified by the same gene, in that both were found defective in six patients with recessive congenital methemoglobinemia. We suggest that the ...
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Two NADH cytochrome b5 reductases from the beet armyworm, Spodoptera exigua: Gene identification, cloning and expression profiles
... NADH-cytochrome-b5 reductase (EC.1.6.6.2, CbR), also known as flavoprotein, is a multi-functional redox enzyme, which is responsible to shuttle electron to other enzymes and could affect the progress of the ...
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The Anticancer Drug Ellipticine Induces Cytochromes P450 1A1, 1A2 and 3A, Cytochrome b5 and NADPH:Cytochrome P450 Oxidoreductase in Rat Liver, Kidney and Lung
... Treatment of rats with 40 mg/kg of ellipticine resulted in changes of patterns of metabolites formed by microsomes isolated from all three organs of these rats. In all organs 9-hydroxyellipticine was formed at ...
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Cytochrome b5 Coexpression Increases Tetrahymena thermophila Δ6 Fatty Acid Desaturase Activity in Saccharomyces cerevisiae
... similar cytochrome b 5 sequences. Three candidate cytochrome b 5 s, CB5A (TTHERM_00420210), CB5B (TTHERM_00051880), and CB5C (TTHERM_00624890) were chosen for further ...duplicate cytochrome b 5 ...
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Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis
... PCR assays to evaluate changes in the mRNA levels of 84 genes related to cell proliferation, apoptosis, cell cycle, angiogenesis, invasion, and metastasis in HONE1 cells that were tra[r] ...
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Estimation of Cytochrome B5 Reductase Activity in Red Blood Cells of Rattus Norvegicus after the Treatment of Trichloroacetic Acid
... reduced methemoglobin-ferrocyanide are given in Table 1. After 20 days of treatment the values in Group II, III, IV and V were 3.58±0.128, 3.44±0.143, 3.66±0.156 and 3.46±0.132 respectively and were significant as ...
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Molecular analysis of the 17alpha-hydroxylase gene and its potential role in hyperandrogenism
... of Cytochrome b5 in some Cushing's syndrome patient, suggested that Cytochrome b5 may have a role in increased expression of the CYP 17 (Sakai et al, ...rabbit Cytochrome b5. ...
200
Photo-cytochrome b5 – A New Tool to Study the Cytochrome P450 Electron-transport Chain
... RESULTS AND DISCUSSION To study the role of cyt b5 in a cytochrome P450 multienzyme electron transport chain, the analogue of cyt b5 containing a photolabile amino acid derivative photo-[r] ...
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Biochemical and anatomical basis of brain dysfunctions caused by cytochrome b5 reductase deficiency or dysregulation
... As an impaired neuronal bioenergetics is a metabolic alteration shared in many neurodegenerative diseases, it is of interest to recall here that the NADH oxidase activity of the Cb 5 R bound to the external mitochondrial ...
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Giardia intestinalis Incorporates Heme into Cytosolic Cytochrome b5
... In G. intestinalis and other anaerobic protists, electron trans- port is primarily dependent on ferredoxins that mediate single electron transfers. These FeS proteins are involved in energy me- tabolism that occurs in ...
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A Cytochrome b5-Containing Plastid-Located Fatty Acid Desaturase from Chlamydomonas reinhardtii
... the cDNA in Saccharomyces cerevisiae or Arabidopsis were not pro- ductive at this time, and modification of Cr⌬4FAD abundance in Chlamydomonas did not alter the fatty acid composition of MGDG per se but affected the ...
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Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence
... In order to assess whether ZtCBR1 ablation had impacted on fatty acid biosynthesis by fungal cells, the fatty acid methyl ester (FAME) profile of the WT strain and D ZtCBR1-1 were analyse[r] ...
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Journal of Applied Pharmaceutical Science
... NADH-cytochrome b5 reductase (pdb id 1NDH) obtained from RCSB protein data bank and the structures of inhibitors generated from smile ...cyt b5 reductase-inhibitor complex generated by Patchdock ...
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Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family
... A search of the HUGO Gene Nomenclature Committee database using ‘NQO’ provided three hits—two NQO genes plus ‘NQO3A2’ (which actually encodes cytochrome b5 reductase-1)—the latter appears in the database ...
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Congenital Methemoglobinemia: A Rare Cause of Cyanosis in the Newborn—A Case Report
... ABSTRACT. Cyanosis is a physical finding that can occur at any age but presents the greatest challenge when it occurs in the newborn. The cause is multiple, and it usually represents an ominous sign, especially when it ...
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Ramanujan type congruences modulo powers of 5 and 7
... Recently, by following the strategy of Hirschhorn and Hunt [5], Wang [11, 12] established several infinite families of congruences modulo powers of 5 for b5 n and B5 n.. In recent days, [r] ...
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Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014
... In total, 210 clinical samples were collected in Chongqing City in 2014. Viruses were isolated from the original clin- ical specimens by propagation in human rhabdomyosar- coma (RD) and human larynxarcinoma (HEp-2) cells ...
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B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy
... of B5 in both cell lines, it was hardly reduced by 16 μM B5 in SiHa cells in spite of autophagy induction under the treatment of this concentration, indicating the involvement of some other pathway(s) in ...
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Performance and emissions of preheated biodiesel on a compression ignition (CI) engines
... The highest NO, emission takes place at 2000 rpm engine speed unexpectedly for both load conditions and the preheat B5 produced higher NOx compared to diesel fuel and unheated B5.. In ad[r] ...
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