B7 family
Comprehensive understanding of B7 family in gastric cancer: expression profile, association with clinicopathological parameters and downstream targets
... We further found out differential proteins that were altered upon B7 family member mutation. Proteins which have significant changes (p < 0.05) were shown in the volcano map (Fig. 4A) and were used for ...
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Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells
... In the past decade we have come a long way in terms of levels of complexity from the original two-signal hypothesis [1], which proposed that T cell activation required stimulation both via the T cell receptor (TCR) ...
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VSIG4, a B7 family–related protein, is a negative regulator of T cell activation
... the B7 family. We have identified a previously unknown function for B7 family–related protein V-set and Ig domain–containing 4 ...of B7 family members, surface expression of ...
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Overexpression of HHLA2, a member of the B7 family, is associated with worse survival in human colorectal carcinoma
... the B7 family, is a novel immune checkpoint molecule, and the prognostic value of HHLA2 in CRC patients and the association between HHLA2 expression and clinicopathological characteristics remains ...
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B7-H3 expression in breast cancer and upregulation of VEGF through gene silence
... Abstract: B7-H3, a novel member of the B7 family, was previously known as a regulatory ligand regulating T-cell-mediated immune response, and in recent years it was found to take a significant role ...
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5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers
... of B7-H1 [5–8]. B7-homolog 1 (B7-H1), also known as programmed death ligand-1 (PD-L1), is an immunoregulatory protein that belongs to the B7 family of T-cell co-regulatory molecules ...
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Peripheral blood natural killer cell percentages in granulomatosis with polyangiitis correlate with disease inactivity and stage
... curve; B7-H6: member of the B7 family of immunoreceptors, ligand for NKp30; BVAS: Birmingham Vasculitis Activity Score; CD: control disease; DMARD: disease-modifying antirheumatic drug; ENT: ear, ...
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Correlation between B7-H3 expression and matrix metalloproteinases 2 expression in pancreatic cancer
... the B7 family and is expressed by lymphoid cells, such as dendritic cells, monocytes/macrophages and activated T cells; non-lymphoid tissue cells express B7-H3 too, such as epithelial cells, anter- ...
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The coexpression and clinical significance of costimulatory molecules B7-H1, B7-H3, and B7-H4 in human pancreatic cancer
... of B7-H1, B7-H3, and B7-H4, and found that more than 50% of patients expressed B7-H1 and B7-H4, whereas nearly 100% of patients expressed ...three B7-family molecules was ...
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Antigen presenting particle technology using inactivated surface engineered viruses: induction of immune responses against infectious agents
... incorporating B7-family members) and/or stimulation through the T cell receptor complex (by incorporating CD3-scFv anti- ...and B7 molecules with the T cell receptor (TCR) and the CD28 receptor on T ...
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Original Article B7-H3 in combination with regulatory T cell is associated with tumor progression in primary human non-small cell lung cancer
... Abstract: B7-H3 belongs to the co-inhibitory B7 family and plays an important role in the adaptive immune response in regulating T ...malignancies, B7-H3 is reported to be involved in tumor ...
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Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells
... Methods: This study aimed to detect the B7 family members B7.1 (CD80) and B7.2 (CD86) that were expressed in B-ALL patient-derived cells pre-treated by Ara-C (0.25 μ M) and to determine [r] ...
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Prognostic significance of B7-H4 expression in matched primary pancreatic cancer and liver metastases
... of B7 family [13–15] and inhibits the T cell mediated response by inhibiting T cell proliferation, activation, and cytokine production [13, 16, ...17]. B7-H4 also inhibits the innate immune response ...
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Original Article Expression of B7-H6 in chronic myeloid leukemia and its clinical significance
... of B7-H6 gene and the relative amount of BCR-ABL1 transcripts in BMMCs and confirmed a negative correlation between th- ...high B7-H6 expression level had longer progression-free ...upregulated B7-H1 ...
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Assessment of combined expression of B7-H3 and B7-H4 as prognostic marker in esophageal cancer patients
... the B7 family ligands not only contribute towards the regulation of T-cell mediated immune response, but also have important implications in the regulation of the biological behaviors of cancer cells, ...
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To be or not to be B7
... The B7 family members are involved at several stages in this ...the B7 family–related protein V-set and Ig domain–containing 4 (VSIG4) can act as an inhibitor of T cell activation (see the ...
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Virus-Encoded B7-2 Costimulation Molecules Enhance the Protective Capacity of a Replication-Defective Herpes Simplex Virus Type 2 Vaccine in Immunocompetent Mice
... express B7 molecules have been used to enhance responses to coexpressed heterologous anti- gens such as tumor-specific epitopes (18, 27, 36, ...coded B7 costimulation molecules enhance protective immune ...
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TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis
... of B7/CD28 superfamily molecules in the cancer microenvironment has been determined as an important immunosuppressive mechanism in many types of human cancers ...CD28 family receptors containing the ...
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Silencing B7-H1 enhances the anti-tumor effect of bladder cancer antigen-loaded dendritic cell vaccine in vitro
... Roswell Park Memorial Institute (RPMI) 1640 culture medium and fetal bovine serum (FBS) were purchased from HyClone (Logan, UT, USA). Recombinant human granulocyte- macrophage colony stimulating factor (rhGM-CSF) and ...
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Expression of B7-H6 expression in human hepatocellular carcinoma and its clinical significance
... the B7-H6 expression in both HCC tissues and normal liver ...for B7-H6 was predominantly localized on the membrane and in the cytoplasm of HCC ...of B7-H6 in HCC tissue. Figure 1b indicates moderate ...
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