B7-H1
Silencing B7-H1 enhances the anti-tumor effect of bladder cancer antigen-loaded dendritic cell vaccine in vitro
... were B7-H1 (forward, 5 ′ -GCC GAC TAC AAG CGA ATT AC-3 ′ ; reverse, 5 ′ -TCT CAG TGT GCT GGT CAC AT-3 ′ , 234 bp) and β -actin (forward, 5 ′ -TCA TGG GTG TGA ACC ATG AGA A-3 ′ ; reverse, 5 ′ -GGC ATG GAC ...
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Local expression of B7 H1 promotes organ specific autoimmunity and transplant rejection
... identified B7 family member whose expression is inducible in a variety of organs (1, ...of B7-H1 in regulating T cell responses in vivo is not fully under- ...by B7-H1 was first ...
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Costimulating aberrant T cell responses by B7 H1 autoantibodies in rheumatoid arthritis
... to B7-H1. BALB/c mice were immu- nized with purified human B7-H1Ig mixed with com- plete Freud’s adjuvant (Sigma-Aldrich, ...with B7-H1Ig in incomplete Freud’s ...to B7-H1 was ...
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B7 H1–expressing antigen presenting cells mediate polarization of protumorigenic Th22 subsets
... prognostic factor for both OS and DFS (Supplemental Table 3). Th22 cells in peritumoral liver tissue produced higher levels of IFN-γ, whereas those in tumor tissue were selectively associated with IL-17 (Figure 5B). ...
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HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer
... IFN-γ-induced B7-H1 expression in HGC27 cells, while a minor effect was observed for JAK1 and STAT3 inhibition ...IFN-γ-induced B7-H1 ...
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Original Article The clinical significance and contribution of the co-stimulatory molecule B7-H1 in human esophageal cancer
... namely B7/CD28 and TNF/ TNFR [3], play an important role in the suppres- sion of immune responses to tumor ...within B7 families, such as B7-H1, B7-H3, and B7-H4, are present in ...
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PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective
... as B7 homolog 1 (B7-H1), was initially discovered by ...Keywords: B7-H1, PD-L1, PD-1, CTLA-4, CD28, immune checkpoint, immunotherapy, immuno-oncology, T cells, tumor-site immune ...
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HIV-1 Tat Protein Induces PD-L1 (B7-H1) Expression on Dendritic Cells through Tumor Necrosis Factor Alpha- and Toll-Like Receptor 4-Mediated Mechanisms
... HIV-1 Tat Protein Induces PD-L1 B7-H1 Expression on Dendritic Cells through Tumor Necrosis Factor Alpha- and Toll-Like Receptor 4-Mediated Mechanisms Rémi Planès,a,b,c Lbachir BenMohamed[r] ...
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Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis
... The magnitude, quality and longevity of CD8 T-cell ef- fector function is positively regulated by CD4 T cells, and negatively regulated by various T-cell inhibitory molecules. CD4 T cells augment CD8 T-cell activation ...
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Original Article B7-H1 expression associates with tumor invasion and predicts patient’s survival in human esophageal cancer
... positive B7-H1 mem- brane/cytoplasm expression was significantly poorer than that of the patients with negative B7-H1 membrane/cytoplasm expression (Ha- zard ratio = ...and B7-H1 ...
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Blockade of B7 H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells
... in-house. B7-H1 -/- mice on a C57BL/6 background were as described (12) and bred ...in-house. B7-H1 -/- Foxp3-GFP and B7-H1 -/- 4Get reporter mice were generated by ...
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Synergistic effects of IL 4 and TNFα on the induction of B7 H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation
... the B7-H1 expressing melanoma cell line UKRV-Mel-14a using the QIAamp DNA Mini Kit (Qiagen) according the manufacturers’ ...The B7-H1 promoter was amplified by PCR with Taq DNA polymerase Kit ...
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Doxorubicin downregulates cell surface B7 H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7 H1 as an anti apoptotic molecule
... of B7-H1 in an in vivo system, we used a mouse model where we xenotransplanted MDA-MB-231 in nude mice in the mammary fat pad to closely mimic human breast ...express B7-H1 [15]. The tumor ...
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The coexpression and clinical significance of costimulatory molecules B7-H1, B7-H3, and B7-H4 in human pancreatic cancer
... of B7-H1, B7-H3, and B7-H4, and found that more than 50% of patients expressed B7-H1 and B7-H4, whereas nearly 100% of patients expressed ...three B7-family ...
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5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers
... induce B7-H1 protein expression [23, ...induce B7-H1 upregulation in HCT 116 cells as detected by western blot analysis, regardless of p53 mu- tational ...status. B7-H1 surface ...
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B7-H1 and B7-H3 are independent predictors of poor prognosis in patients with non-small cell lung cancer
... characteristics. B7-H1 and B7-H3 expression was measured as the percentage of tumor cells displaying immunoreactivity in the cytoplasm or on the membrane, which was determined by counting the number ...
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Original Article Promotion of tumor immune escape by PI3K/Akt and MEK/ERK-mediated endothelial cells in colorectal cancer
... of B7-H1, FasL, TGF-β and COX-2 mRNA expressions in SW480 cell by qRT-PCR PCR was amplified by ABI7900PCR ...of B7-H1, FasL, TGF-β and COX-2 and β-actin were taken as internal ...follows: ...
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TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis
... of B7/CD28 superfamily molecules in the cancer microenvironment has been determined as an important immunosuppressive mechanism in many types of human cancers ...seven B7 family ligands including ...
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Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
... cells; B7-H1: B7-homolog 1; BTLA: B and T lymphocyte attenuator; CAR: Chimeric antigen receptor; CD137: 4-1BB; CLL: Chronic lymphocytic leukemia; CTL: Cytotoxic T lymphocyte; CTLA-4: Cytotoxic T ...
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PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy
... Beta-2-microglobulin; B7-H1: B7 homolog1; BRAF: B-Raf proto-oncogene; BTC: Biliary tract cancer; CIN: Chromosomal instability; CRC: Colorectal cancer; CTLA4: Cytotoxic T-lymphocyte antigen-4; DCR: ...
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