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Basal Cell Carcinoma

Sonidegib,  a novel smoothened inhibitor for the treatment of advanced basal cell carcinoma

Sonidegib, a novel smoothened inhibitor for the treatment of advanced basal cell carcinoma

... Abstract: Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer. If left untreated, BCCs can become locally aggressive or even metastasize. Currently available treat- ments include ...

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Basal Cell Carcinoma in a 12-Year-Old Boy

Basal Cell Carcinoma in a 12-Year-Old Boy

... Nevoid basal cell carcinoma syndrome Numerous basal cell carcinomas (mean Autosomal dominant; numerous basal onset: 15 y) on sun-exposed and non- cell nevi, jaw cysts, planter and palmar[r] ...

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Identification of critically carcinogenesis-related genes in basal cell carcinoma

Identification of critically carcinogenesis-related genes in basal cell carcinoma

... in cell cycle and mitosis, while the downregulated genes were mainly associated with unsaturated fatty acid metabolic process and cell ...“basal cell carcinoma”, and “hedgehog signaling ...

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Treatment of superficial basal cell carcinoma with ingenol mebutate gel, 0.05%

Treatment of superficial basal cell carcinoma with ingenol mebutate gel, 0.05%

... Background: Basal cell carcinoma (BCC) is the most common cancer in Caucasians. Surgi- cal approaches are the most widely used and effective treatment strategies for well-defined BCC. However, for ...

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Biochemical pathways and targeted therapies in basal cell carcinoma: A systematic review

Biochemical pathways and targeted therapies in basal cell carcinoma: A systematic review

... Abstract: Basal cell carcinoma (BCC) is the most common type of human ...of Basal Cell Nevus Syndrome (BCNS), characterized by a predisposition to the formation of BCC and other ...

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Detection of BasalCell Carcinoma–aGuideLine forGeneralPractitioners in Dentistry

Detection of Basal Cell Carcinoma–a Guide Line for General Practitioners in Dentistry

... Basal cell carcinoma is the most common malignant cancer of skin, frequently affecting the head and neck region; it can cause significant destruction and disfigurement by invading surrounding ...

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Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma

Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma

... Background: The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain ...

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Original Article Basal cell carcinoma arising from the epidermoid cyst

Original Article Basal cell carcinoma arising from the epidermoid cyst

... the basal layer of the squamous epithe- lium (Figure ...diagnose basal cell carcinoma (Figure ...the basal cell carcinoma (Figure ...

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Review of photodynamic therapy in actinic keratosis and basal cell carcinoma

Review of photodynamic therapy in actinic keratosis and basal cell carcinoma

... melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma ...squamous cell carcinoma in situ (SCCIS), also called Morbus Bowen, are precursors of SCC and therefore ...

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Evaluation of the Level of Zinc and Malondialdehyde in Basal Cell Carcinoma

Evaluation of the Level of Zinc and Malondialdehyde in Basal Cell Carcinoma

... BCC is one of the most common malignancies among human neoplasms especially in peoples with light skins (1, 2). Around 80% of non- melanoma skin cancers are associated with BCC (3). BCC is mostly seen in individuals from ...

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Cardiac Tumors and the Nevoid Basal Cell Carcinoma Syndrome

Cardiac Tumors and the Nevoid Basal Cell Carcinoma Syndrome

... The syndrome of multiple cysts of the jaws, basal cell carcinomata, and skel- etal anomalies. Nevoid basal cell carcinoma syndrome.[r] ...

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Trends of basal cell carcinoma at the Centre of Dermatovenereology of Vilnius University

Trends of basal cell carcinoma at the Centre of Dermatovenereology of Vilnius University

... objectives. Basal cell carcinoma is the most common locally invasive malignant epidermal neoplasm in hu- mans and its incidence has increased over the last decades world- wide, especially among the ...

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Vismodegib Provides a Novel Treatment for Advanced Basal Cell Carcinoma

Vismodegib Provides a Novel Treatment for Advanced Basal Cell Carcinoma

... metastatic basal cell carcinoma (mBCC) that has recurred after sur- gery or for patients in which surgery or radiation is not an ...cancer cell growth and survival by binding Smoothened, a ...

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Treatment of Basal Cell Carcinoma by Topical 25% Podophyllin Solution

Treatment of Basal Cell Carcinoma by Topical 25% Podophyllin Solution

... Background: Basal cell carcinoma is the most common malignancies of the ...of basal cell ...with basal cell carcinoma enrolled in this open labeled interventional ...

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Metastatic Basal Cell Carcinoma: A Rare Manifestation of a Common Disease

Metastatic Basal Cell Carcinoma: A Rare Manifestation of a Common Disease

... Copyright © 2017 Paola Piva de Freitas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, ...

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Investigational agents in metastatic basal cell carcinoma: focus on vismodegib

Investigational agents in metastatic basal cell carcinoma: focus on vismodegib

... by basal cell ...of basal cell carcinoma, the pharmacology and the clinical activity of vismodegib, as well as a brief summary of investigational agents in development targeting this ...

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Basal cell carcinoma — molecular biology and potential new therapies

Basal cell carcinoma — molecular biology and potential new therapies

... Basal cell carcinoma (BCC) of the skin, the most common malignancy in individuals of mixed European descent, is increasing in incidence due to an aging population and sun exposure ...tumor ...

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A neglected basal cell carcinoma in a young patient:successful treatment with immunocryosurgery

A neglected basal cell carcinoma in a young patient:successful treatment with immunocryosurgery

... Basal cell carcinoma is a tumor of elderly individuals, ...tumor cell nests in this case extended relatively deeply into the interfollicular dermis and were not confined to the superficial ...

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Peroxidative Activity in Patients with Skin Basal Cell Carcinoma

Peroxidative Activity in Patients with Skin Basal Cell Carcinoma

... human basal cell carcinoma (BCC), which is the most common tumor in the ...human basal cell carcinoma (BCC) and individually matched normal skin tissue were examined with ...

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Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

... cutaneous basal cell carcinoma and is thought to be an early genetic factor in its tumourigenesis ...stem cell niche is favoured by loss-of-function mu- tation in PTCH1 that allows upregulated ...

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