basal-like
Epidemiology of basal-like breast cancer.pdf
... There are a number of limitations to PAF estimates, since they are based upon very strong assumptions. First, PAFs estimate the proportion of disease that would be eliminated if the entire population was moved from the ...
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Association between mammographic density and basal like and luminal A breast cancer subtypes
... Table 2 presents the ORs and 95% CIs for adjusted models with both BI-RADS 1 (model 1) and 2 (model 2) as the reference groups. Model 1 is included to facilitate comparison with previous studies that have reported risk ...
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The Met oncogene and basal like breast cancer: another culprit to watch out for?
... the basal-like sub- group express high levels of basal markers, such as cytokeratins 5/14/17 and laminin, and do not express ERα, progesterone receptor and ...with basal-like features, ...
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A clinically relevant gene signature in triple negative and basal like breast cancer
... expression data which is not the standard definition used in the clinic. This might be a caveat but holds the promise that samples erroneously characterized as receptor-negative by immunohistochemistry do not introduce ...
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Embryonic mammary signature subsets are activated in Brca1 / and basal like breast cancers
... of basal-like and non-basal-like cancers in the Natrajan ...stable basal-like clusters were observed (see Additional file ...in basal-like breast cancers compared ...
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CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal like breast cancer
... the basal-like subgroup is currently available. Basal- like breast cancer comprises about 15% of all invasive breast cancers and is likely to be high-grade, occur in young women, and have an ...
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Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma.pdf
... a basal-like stem cell, characterized by its preferential expression of cytokeratin 5/6 and low expression of luminal cytokeratins (cytokeratin 8/18), might represent a breast cancer ...between basal ...
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Metabolic biomarkers for response to PI3K inhibition in basal like breast cancer
... needed. Basal-like breast cancer (BLBC) is an aggressive breast cancer subtype, frequently associated with PI3K pathway ...representing basal-like and luminal-like breast cancer before ...
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WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling
... studies. Lentivirus-mediated shRNA was used to knock- down Wnt5b expression in Hs-578 T, MDA-MB-231, and Bcap-37 cells. sh-WNT5B-2 and WNT5B-3 showed high efficiency of knockdown and were chosen for further stud- ies ...
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FOXF2 deficiency promotes epithelial mesenchymal transition and metastasis of basal like breast cancer
... in basal-like subtype breast cancer, but are less present in luminal subtype ...most basal-like breast cells. Since basal-like breast cells are characterized by the basal ...
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Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas
... Both Robens et al. and our present study demon- strated a significantly higher frequency of TTF-1 positiv- ity in histological grade 3 tumors. As novel observations, we here find significantly more TTF-1 positive tumors ...
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Calpain system protein expression in basal like and triple negative invasive breast cancer
... HER2, basal-like and lymphovascular invasion were included [with individual Kaplan – Meier statistics of P < ...and basal-like (P = ...
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Differential Expression of Glu Tubulin in Basal Like Phenotype Carcinoma of the Mammary Gland
... High levels of tubulin expression have been described in a variety of human malignant tumors, and glu-tubulin, in which the C-terminal tyrosine of α-tubulin is removed by tubulin carboxypeptidase. Over-expression has ...
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FOXC1 identifies basal-like breast cancer in a hereditary breast cancer cohort
... the basal-like phenotype defined by IHC markers (ER-PR-HER2-/EGFR+/CK5/6+): 92% (33/36) of FOXC1+ tumors were basal, and nearly all basal tumors (92%; 25/28), demonstrated FOXC1 staining ...
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Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers
... 2)-positive, basal-like breast tumors (BLBC) and normal-like ...of basal markers (cytokeratin 5/6, 14 and 17) ...BLBC, basal cytokeratin expression is associated with poor clinical ...
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Isolation and characterization of a new basal-like luminal progenitor in human breast tissue
... + basal-like luminal pro- genitors that originate from the NR3 − CD90 + bipotent ...these basal-like lu- minal progenitors (BLPs) generate pure luminal colonies based on NR3 and FZD7-Wnt7A ...
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Weight loss reduces basal-like breast cancer through kinome reprogramming
... The normal microenvironment can suppress tumor progression, but when the homeostasis is interrupted (e.g. by obesity, etc.), the microenvironment can pro- mote tumor growth [24]. Therefore, histopathologic analysis was ...
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Basal-like breast cancer: molecular profiles, clinical features and survival outcomes
... subgroups. Basal I (Immune Active) show molecular overlaps and phenotypic similarities with BLIA [20], IM [19] and C3 [21]; Basal II (High Prolif- erative) matched with BLIS [20] and C2 ...in ...
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Morphological and immunophenotypic analysis of basal-like carcinoma of the breast
... the basal-like tumour of the ...B, basal-like and basal-like HER2 over expressing ...The basal-like group was defined in this study by tumours which displayed ER ...
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Genome remodelling in a basal-like breast cancer metastasis and xenograft.pdf
... Because basal- like breast cancer has a highly unstable genome, a key question is whether the fatal metastatic process is driven by mutations that occur after the tumour cells arrive at the distant site, or ...
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