Base Excision Repair
Base excision repair and the role of MUTYH
... DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour ...of base excision repair are relatively well understood and are placed ...
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Studies on protein:protein interactions in mammalian DNA base-excision repair
... 24 reported for NER are in contrast to the base excision repair pathway, where pair-wise protein iprotein interactions occur at the site of damage. The first step in NER is the recognition of the ...
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XRCC1 and base excision repair balance in response to nitric oxide
... labile base lesions in single cells [60, 63, 78, ...DNA base excision repair intermediates, following exposure to inflammatory ...of base excision repair intermediates ...
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Trinucleotide Repeat Instability is Modulated by DNA Base Lesions and DNA Base Excision Repair
... Base excision repair is the major pathway of repairing oxidative damage and ssDNA ...the repair DNA polymerase and allow further DNA slippage ...
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Evidence That Msh1p Plays Multiple Roles in Mitochondrial Base Excision Repair
... Mitochondrial DNA is thought to be especially prone to oxidative damage by reactive oxygen species generated through electron transport during cellular respiration. This damage is mitigated primarily by the base ...
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Modulation of the base excision repair (BER) pathway in the treatment of glioblastoma with radiotherapy.
... DNA repair protein expression profiles in glioblastoma cell ...DNA repair pathway named base excision repair (BER) is of particular interest as the main treatment strategies for ...
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Active demethylation in mouse zygotes involves cytosine deamination and base excision repair
... Abstract Background: DNA methylation in mammals is an epigenetic mark necessary for normal embryogenesis. During development active loss of methylation occurs in the male pronucleus during the first cell cycle after ...
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Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
... FIG. 1. BER and ER 1 breast cancer. Kaplan–Meier curves showing BCSS strati- fied based on BER prognostic index score. BCSS, breast can- cer specific survival; BER, base excision repair; ER, es- ...
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Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity
... Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity Michel J. Massaad, 1 Jia Zhou, 2 Daisuke Tsuchimoto, 3 Janet Chou, 1 Haifa Jabara, 1 Erin Janssen 1 , ...
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ALC1/CHD1L, chromatin-remodeling enzyme, is required for efficient base excision repair
... Introduction Base excision repair (BER) eliminates nucleotides damaged by oxidation, alkylation, and ...damaged base, leading to the for- mation of apurinic/apyrimidinic (AP) sites, followed ...
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Breast Cancer Susceptibility Gene in Base Excision Repair Pathway in a Southern Indian Population
... Aim: To determine the association of the two polymorphisms (rs25487 and rs1799782) of the gene XRCC1 involved in the Base Excision Repair (BER) pathway with breast cancer risk. Materials and Methods: ...
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The adaptive imbalance in base excision–repair enzymes generates microsatellite instability in chronic inflammation
... two base excision–repair enzymes , AAG, the major 3-methyladenine DNA glycosylase, and APE1, the major apurinic site endonuclease; and (b) the prevalence of microsatellite instability ...
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8 Oxoguanine causes neurodegeneration during MUTYH mediated DNA base excision repair
... MUTYH-mediated excision repair of 8-oxoG–paired ...during base excision repair initiated by MUTYH, suggesting that suppression of MUTYH may protect the brain under conditions of ...
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Link between Base Excision Repair (BER), Reactive Oxygen Species (ROS), and Cancer
... Base Excision Repair Targeted Treatment Cancer therapy is a modified chemotherapy that involves ionizing radiations or other types of DNA damaging cytotoxic process in addition to molecules that ...
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Genetic polymorphism in DNA base excision repair gene XRCC1among medical radiation workers
... X-rays repair cross-complementing group 1 (XRCC1) gene is one of the gene that plays an important role in base excision repair system (BER) and DNA repair both single and double strand ...
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Base Excision Repair Inhibition by Methoxyamine Impairs Growth and Sensitizes Osteosarcoma Cells to Conventional Treatments
... a base excision repair (BER) inhibitor that has shown anticancer potential by sensitizing a variety of tumor cells to ionizing radiation and chemotherapeutic ...
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Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy
... DNA repair mechanisms, such as base excision repair (BER) and mismatch repair (MMR), may not only influence tumour characteristics and prognosis but also dictate chemotherapy ...
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The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions
... that base excision repair (BER) rec- ognizes 5-azadC-induced lesions in DNA and medi- ates ...the repair of trapped ...in repair of 5-azadC-induced DNA ...
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Base excision repair of ionizing radiation-induced DNA damage in G1 and G2 cell cycle phases
... the repair of damaged DNA. Cells have developed multiple DNA repair pathways to protect themselves from different types of DNA ...the base excision repair (BER) ...cycle-specific ...
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DNA repair genes polymorphisms and genetic susceptibility to Philadelphia-negative myeloproliferative neoplasms in a Portuguese population: the role of base excision repair genes polymorphisms
... of base excision repair (BER) genes in Philadelphia-negative (PN)-myeloproliferative neoplasms (MPNs) susceptibility was evaluated by genotyping eight polymorphisms [apurinic/apyrimidinic ...
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