BBB, blood–brain barrier
Spontaneous penetration of gold nanoparticles through the blood brain barrier (BBB)
... the BBB were investigated in order to complete the characterization ...The BBB, as others bar- riers in the body, is composed of different tissue ...the BBB as a uniform organ without addressing ...
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Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer’s disease
... triphosphate; BBB: blood–brain barrier; BCSFB: blood–CSF barrier; CA: carbonic anhydrase; CLDN: claudin; Cq1: com- plement factor q1; CSF: cerebrospinal fluid; CP: choroid ...
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Fibrinogen is not elevated in the cerebrospinal fluid of patients with multiple sclerosis
... BBB: blood-brain barrier; BCSFB: blood-CSF barrier; BM: bacterial meningoencephalitis; CEL: contrast enhancing lesions; CSF: cerebrospinal fluid; CNS: central nervous system; CP: ...
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The endotoxin hypothesis of neurodegeneration
... protein; BBB: Blood-brain barrier; C3: Complement component 3; CVO: Circumventricular organs; EU: Endotoxin units; FTD: Frontotemporal dementia; HDL: High-density lipoproteins; IL: ...
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Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole
... The blood-brain barrier (BBB), which is formed by the tight junctions of brain capillary endothelial cells, expresses various transporters to regulate exchange of compounds between the ...
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Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain
... vivo blood-to-brain transport of p-TA is low [11, ...the brain is relatively greater compared with that of p-TA ...[14]. Brain barriers are involved in the clearance of several neural ...
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Original Article Levels of oligomeric alpha-synuclein in red blood cells are elevated in patients with Parkinson’s disease and affected by brain alpha-synuclein expression
... the blood-brain barrier (BBB) into blood plasma [24], there is a high possibility that the increased brain α-syn can make more α-syn that is released into blood plasma, ...
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Nanoscale drug delivery systems and the blood–brain barrier
... the blood–brain barrier (BBB) are conferred by the intricate architecture of its endothelium coupled with multiple specific transport systems expressed on the surface of endothelial cells ...
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Blood brain barrier regulation in psychiatric disorders
... Increased BBB permeability has been proposed as a potential risk factor in schizophrenia, though whether it is a primary cause or a re- lated symptom is unclear ...suring BBB permeability in humans is ...
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Engineering the human blood-brain barrier in vitro
... in BBB induction and maintenance was mostly overlooked until several groups demonstrated their importance in vivo [8, 45, ...sive BBB breakdown and cognitive impairment, demon- strating that pericyte loss ...
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Basement membrane and blood–brain barrier
... levels is largely unknown due to its intrinsic complexity and the lack of research tools. With the advancement in genetics and biochemistry, we are starting to answer this important question. This knowledge will ...
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BRAIN DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW ON RECENT EXPERIMENTAL AND CLINICAL FINDINGS
... The blood- brain barrier (BBB) denies many therapeutic agents access to brain tumors and other diseases of the central nervous system ...the brain diseases and the actions of ...
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Studying Molecular Aspects of the Blood Brain Barrier Using an in Vitro Model: Contribution of a Global Proteomics Strategy
... The blood-brain barrier (BBB) corresponding to the cerebral capillaries covers approximately 95% of the total area of barriers between blood and brain ...the brain ...
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Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF
... the BBB is through the transcellular route rather than the paracellular ...the brain may be mediated by BMEC-derived cytokines secreted into blood or by blood-borne ...the blood ...
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Transport of the pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier: implications for migraine
... the blood, which was not true for ...the BBB via a saturable mechanism, whereas the PACAP27 uptake must be via a non-saturable mechanism ...the brain was ...the brain to blood via the ...
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The role of plasmalemma vesicle-associated protein in pathological breakdown of blood–brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema
... the blood–brain barrier (BBB) or inner blood–retinal barrier (BRB), induced by pathologically elevated levels of vascular endothelial growth factor (VEGF) or other mediators, can ...
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Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
... the BBB or related blood-spinal cord barrier (BSCB) in other animal models of neurological disease, including stroke [56, 57], intracerebral hemorrhage [58], intracerebral LPS injection [59], MPTP ...
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Online Full Text
... he blood-brain barrier (BBB) presents a real challenge to the pharmaceutical ...The BBB is very effective screener of diverse kinds of bacterial ...
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Breast cancer brain metastases: biology and new clinical perspectives
... of brain metastases (BM) has become a major limitation of life expectancy and quality of life for many breast cancer ...the brain, single tumor cells must pass through the tight blood – brain ...
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The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell to Cell Connections
... the blood-brain barrier (BBB) represents, a physical and functional barrier, able to provide all these functions, separating the CNS from systemic ...characterizing brain ...
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