Benzodiazepine receptor
Deprescribing benzodiazepine receptor agonists
... BZRA—benzodiazepine receptor agonist, CBT—cognitive-behavioural therapy, COPD—chronic obstructive pulmonary disease, NNT—number needed to treat, QoE—quality of evidence, RCT—randomized controlled ...
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PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS
... Specific binding was significantly higher in the frontal white and gray matter, basal ganglia, and hippocampal areas of encephalitic macaques P < 0.004 compared with binding in these reg[r] ...
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GABAA/benzodiazepine receptor distribution and subunit mRNA expression in human temporal lobe epilepsy
... On the day of the assay, sections were removed from the -80°C freezer and allowed to stand at room temperature for one hour. To reduce endogenous GABA levels in the tissue, sections were preincubated in assay buffer, ...
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Commentary: Benzodiazepine (BZD) and Related BZD Receptor Agonists: Basic Science Reasons to Limit to Four Weeks or Less
... related benzodiazepine-receptor agonists such as the pyrazolopyrimidinezaleplon; the imidazopyridine zolpidem; and the cyclopyrroloneszopiclone and eszopiclone, are among the most widely pre- scribed drugs, ...
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Original Article Expression of 18 KDa translocator protein by microglia in spinal cord and hippocampus in rats with neuropathic pain
... peripheral receptor for benzodiazepine in 1977 ...central benzodiazepine receptor (CBR) due to their affinity to benzodiazepine, ...
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Effects of acupuncture on the hypothalamus pituitary adrenal axis in chronic insomnia patients: a study protocol for a randomized controlled trial
... BzRAs: Benzodiazepine receptor agonists; CBT: Cognitive behavioral therapy; CIPs: Chronic insomnia patients; CORT: Cortisol; CRF: Case report form; CRH: Corticotrophin-releasing hormone; EA: ...
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Valium without dependence? Individual GABA<sub>A</sub> receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
... 124. Zanotti A, Mariot R, Contarino A, Lipartiti M, Giusti P. Lack of anticonvulsant tolerance and benzodiazepine receptor down regulation with imidazenil in rats. Br J Clin Pharmacol. 1996;117(4):647–652. ...
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Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response
... Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PB[r] ...
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Biocatalyzed C-C bond formation for the production of alkaloids
... For instance, the -carboline scaffold is a part of numerous agonists and inverse agonists of benzodiazepine receptor.[28,29,33,34] Benzodiazepine receptors play a pivotal role in the con[r] ...
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Nifedipine and Nitrendipine Stimulate Cholesterol Hydroxylation in Rat
... peripheral benzodiazepine receptor (PBR) facilitates the transport of cholesterol from outer to the inner mitochondrial membranes in liver mitochondria, where the enzyme sterol 27-hydroxylase is ...
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Relaxation of rat vascular muscle by peripheral benzodiazepine modulators
... peripheral benzodiazepine receptor modulating drugs, Ro 5-4864 and PK 11195, on tension induced by K+ and the calcium agonist SDZ 202 791 (S isomer), were studied in rat caudal ...
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TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria
... signaling and redox stress homeostasis. However, recent studies on gene-edited mice (knocked out for TSPO) have ruled this out and showed that MPTP is formed regardless of the presence of TSPO (32-36). Nevertheless, a ...
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Synthesis and molecular docking studies of 1 trityl 5 azaindazole derivatives
... minutes-2(MDM2) receptor bind p53 and Pheripheral benzodiazepine receptor (PBR) cancer ...PBR receptor protein with binding energy ranging from ...MDM2 receptor bind p53 protein which ...
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Nociception-specific blink reflex: pharmacology in healthy volunteers
... We have shown in a carefully conducted three-way crossover study in volunteers a reduction of the noci- ception specific blink reflex with the benzodiazepine receptor agonist diazepam. We have seen no clear ...
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Efficient one pot synthesis of [1,2,4]triazolo[4,3 α][1,4] benzodiazepines derivatives
... Most of these synthetic approaches suffer from drawback such as harsh reaction conditions (high temperature) and multistep synthesis. N-Aryl-hydrazino-1,4-benzodiazepine derivative never undergo complete ...
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First benzodiazepine prescriptions
... Physicians should develop communication strategies to persuade their patients that they take the patients’ problems seriously even though consultations do not always end with prescript[r] ...
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The quality of primary care provided to the elderly in Israel
... of benzodiazepine overuse, and long-term benzodiazepine use were similar, yet whereas in most OECD countries pre- scriptions of benzodiazepines were counted, the Israeli data allowed a more accurate ...
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High and Low Rearing Rats Differ in the Brain Excitability Controlled by the Allosteric Benzodiazepine Site in the GABAA Receptor
... proconvulsant benzodiazepine inverse agonist that does not increase hippocampal LCGU, with those of DMCM suggests that the hippocampus may be of major importance for the initiation of seizures induced by DMCM ...
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Current clinical drug on benzodiazepine
... Benzodiazepines (BDZ) are the most commonly used drugs for anxiety disorders, because of their anxiolytic, hypnotic, muscle relaxant and anticonvulsant properties. Through the receptorial binding with the GABA A ...
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<p>Management of Alcohol Withdrawal in the Emergency Department: Current Perspectives</p>
... symptom-triggered benzodiazepine administration remains the most commonly provided treatment but may not be appropriate for patients with signi fi cant medical or psychiatric comorbidity or pending ...
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