BET proteins
Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis
... of BET inhibitors in preclinical models of renal ...a BET specific bromodomain inhibitor, can suppress inflammation and kidney injury in murine models of HIV- associated nephropathy and diabetic nephropathy ...
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Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis
... Thus, BET proteins are a group of epigenetic regulators that bind to acetylated lysine on histone tails to regulate chromatin accessibility to transcription factors and RNA polymerase [7, ...target ...
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The Interaction of the Gammaherpesvirus 68 orf73 Protein with Cellular BET Proteins Affects the Activation of Cell Cycle Promoters
... BET proteins interact via their bromodomains with acety- lated histones (13, 30, 33) and are highly conserved, with mem- bers in plants, yeast, Drosophila melanogaster, and up to mam- mals ...of BET ...
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Foamy Virus Bet Proteins Function as Novel Inhibitors of the APOBEC3 Family of Innate Antiretroviral Defense Factors
... APOBEC3 proteins play a role in restricting primate foamy virus replication in infected humans? To address this hypothesis, we first asked whether a vector derived from the PFV foamy virus isolate, which appears ...
8
Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelial carcinoma cell lines
... chromatin proteins by targeting domains recognizing histone modifi- ...(BET) proteins, especially BRD proteins, and appears to be particularly effective in cancers dependent on MYC ...
14
Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation
... of BET inhibition on the expression of differentiation markers in melanoma cells when we compared a published data set [37] with our results in ...that BET inhibition can cause de-pigmentation by reducing ...
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Bi-directional regulation of cartilage metabolism by inhibiting BET proteins—analysis of the effect of I-BET151 on human chondrocytes and murine joints
... [7]. BET protein inhibitors show therapeutic effi- cacy in cancer and inflammation diseases ...a BET family protein in- hibitor, suppressed the expression of inflammatory genes induced by IL-1β and TNF-α in ...
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Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
... (BET) proteins bind to acetylated histones and transcription factors and act as molecular scaffolds between chroma- tin and transcriptional machinery to regulate gene ex- pression ...conditions, BET ...
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BET inhibition as a new strategy for the treatment of gastric cancer
... BET proteins are key mediators in the process of transcription of many genes involved in proliferation and anti-apoptotic and cell cycle progression ...[41]. BET specific inhibitors have shown ...
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Histone modifications and their role in epigenetics of atopy and allergic diseases
... cell; BET (proteins): bromodomain and extra-terminal (proteins); CB: cord blood; CCL2/17/22: C–C motif chemokine ligand 2/17/22 gene; COX2: cytochrome c oxidase subunit II (COX2) gene; CXCL8: C–X–C ...
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The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins
... paralogous BET proteins, which are summarized in Table 1 together with the pathological functions of the ...These proteins have a common feature of epigenetic transcriptional regulators that ...
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Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration
... with BET proteins, BRD2 and BRD4, is limited to and conserved among gammaretroviral ...(iv). Proteins recovered on glutathione Sepharose beads were separated by SDS-PAGE and detected with Coomassie ...
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BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo
... BRD proteins have shown that BRD proteins can have overlapping as well as distinct ...different BET proteins in regulation of collagen I expression in primary cancer-associated ...though ...
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Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer.
... extra-terminal) proteins regulate gene expression through their ability to bind to acetylated chromatin and subsequently activate RNA PolII-driven transcriptional ...molecule BET inhibitors prevent binding ...
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Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
... the BET bromodomain BRD4 inhibitor JQ1 was the only small molecule inhibitor tested that suppressed PD-L1 expression ...of BET proteins with 170-fold more specificity than the ...
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T-bet controls severity of hypersensitivity pneumonitis
... T- bet [20,21] and we sought to determine whether ...T- bet -/- mice, the levels of MIP-2 mRNA, which is strongly induced in HP, was similar to IL-18 -/- and WT ...
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Better Refined Adsorption Isotherm than BET Equation
... The base of Eq. (10) and Eq. (12) is β a + a . So we may use the word, the rate without the dimensionless analysis. It affects the equation totally. Fig. 2 shows the total adsorption rate according to the values of β a . ...
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Optimizing Fractional Intensity Threshold for FSLBrain Extraction Tool (BET) and Comparing with FreeSurfer on 3D T1W MR Images
... Methods: This retrospective study was performed in 10 healthy adult subjects with data of 3D-T1W on 3T MR machine. The manual gold standard brain volume measurements were done by two independent readers. The automated ...
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"White men can't jump," but would you bet on it?
... To the best of our knowledge, the only other paper which addresses the intersection of race and ine¢ciencies in sports betting is Larsen, Price, and Wolfers (2008). They …nd that the relationship between race and fouls, ...
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BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
... same level of MYC and MYC downregulation after JQ1 treatment as cell lines which responded well to JQ1. The other cell line (UW-228) with a minor response to JQ1, did not express detectable MYC levels in western blots. ...
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