Beta-Adrenergic Receptors
In Vitro Desensitization of Beta Adrenergic Receptors in Human Neutrophils ATTENUATION BY CORTICOSTEROIDS
... accumulation in the cells. Two types of receptor alterations were documented. There was a 40% reduction in the number of beta adrenergic receptors (42 vs. 25 fmol/mg protein, P < 0.005) present ...
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Beta adrenergic receptors in lymphocytes and granulocytes from patients with cystic fibrosis
... of beta adrenergic receptors, as determined by equilibrium binding of [3H]dihydroalprenolol to granulocyte particulates, was the same in normal (1,462 +/- 249 receptors/cell) and CF (1,621 +/- ...
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Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure
... 5%). Beta-Adrenergic receptor-mediated stimulation of adenylate cyclase and maximal stimulation with Gpp(NH)p or sodium fluoride was reduced in heart ...fell, beta-adrenergic receptor density ...
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In vivo regulation of beta adrenergic receptors on mononuclear leukocytes and heart Assessment of receptor compartmentation after agonist infusion and acute aortic constriction in guinea pigs
... of beta-adrenergic receptors occurred in the MNL of animals treated in this manner, whereas the number of receptors in the sarcolemmal fraction decreased ...cardiac receptors may result ...
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Rapid desensitization of neonatal rat liver beta adrenergic receptors A role for beta adrenergic receptor kinase
... of beta-adrenergic receptors (BAR) to agonists often leads to a rapid loss of receptor ...specific beta-adrenergic receptor kinase (BARK), leading to functional uncoupling from adenylyl ...
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Noncoordinate regulation of cardiac Gs protein and beta adrenergic receptors by a physiological stimulus, chronic dynamic exercise
... cardiac beta-adrenergic receptors and the stimulatory guanine nucleotide-binding protein, ...atrial beta-adrenergic receptors, but the dose of isoproterenol yielding a 50% ...
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Beta Adrenergic Receptors of Polymorphonuclear Particulates in Bronchial Asthma
... In further studies we examined the interaction of the agonist (−)-isoproterenol with beta adrenergic receptors in 8 normal subjects and 10 asthmatics not receiving adrenergic medication. We ...
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Direct relationship between mononuclear leukocyte and lung beta adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha and beta adrenergic receptors by the sympathochromaffin system in humans
... lung beta-adrenergic receptor densities were not positively related to plasma catecholamine concentrations (they tended to be inversely related to plasma norepinephrine and epinephrine [r = ...and ...
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Identification of beta adrenergic receptors in human lymphocytes by ( ) (3H) alprenolol binding
... mononuclear leukocytes. Binding of (-) [3H] alprenolol to these sites demonstrated the kinetics, affinity, and stereospecificity expected of binding to adenylate cyclase-coupled beta-adrenergic ...
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Increased fat and skeletal muscle beta adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis
... altered adrenergic receptors, even in relevant target tissues, should not be extrapolated to altered sensitivity to catecholamines in vivo in the absence of direct testing of ...
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Endogenous sensitizer of beta-adrenergic receptors (ESBAR) and its analogs (review)
... of beta-AR (possibly due to inhibition of kinase of beta-AP, proteinkinase A and proteinkinase C) and accelerate the dephosphorylation of beta-AR by activating phosphatase, and (like chaperones) ...
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The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms
... tumors and the dissemination of hematopoietic malignancies via the β -adrenoreceptor-mediated activation of protein kinase A (PKA) and the activation of exchange proteins by the adenylate cyclase signaling pathways. ...
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Coregulation of calcium channels and beta adrenergic receptors in cultured chick embryo ventricular cells
... determinations were performed in similar intact cell preparations under identical conditions. 4-h exposure to 1 microM isoproterenol reduced cell surface beta-adrenergic receptor number from 44 +/- 3 to 17 ...
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Effects of pressure overload, left ventricular hypertrophy on beta adrenergic receptors, and responsiveness to catecholamines
... dP/dt. beta-adrenergic receptor binding studies with [3H]-dihydroalprenolol ( [3H]DHA) indicated that the density of binding sites was significantly elevated, P less than ...
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Exercise induced pulmonary vasoconstriction during combined blockade of nitric oxide synthase and beta adrenergic receptors
... We studied the effects of inhibition of nitric oxide (NO) (endothelium-derived relaxation factor) synthase in combination with alpha and beta adrenergic receptor blockade on pulmonary vascular tone during ...
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Differential regulation of right and left ventricular beta adrenergic receptors in newborn lambs with experimental cyanotic heart disease
... myocardial beta-adrenergic receptor/adenylate cyclase system, we produced chronic hypoxemia in nine newborn lambs by creating right ventricular outflow obstruction and an atrial septal ...controls. ...
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Autoradiographic characterization of beta adrenergic receptors in coronary blood vessels and myocytes in normal and ischemic myocardium of the canine heart
... metoprolol, a beta one selective antagonist, demonstrated a KD of 0.7 X 10(-6) M. For autoradiography, emulsion-coated coverslips were attached to the slides. After exposure, the slides were developed and stained, ...
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Beta adrenergic and muscarinic cholinergic receptors in canine myocardium Effects of ischemia
... of beta adrenergic receptors in ischemic left ventricular tissue without changing the number of muscarinic cholinergic ...cardiac beta-receptor content is causally related to increased cyclic ...
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Relation between Depression and Hormonal Dysregulation
... on beta-adrenergic post synaptic receptors (Whybrown et ...creasing beta-adrenergic receptor ...in beta-adrenergic receptors, and thus a decrease in noradrenergic ...
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Vascular Resistance Responses of an Eel Tail Preparation: Alpha Constriction and Beta Dilation
... Adrenaline AD and noradrenaline NA both increased vascular resistance, while isoprenaline decreased resistance which suggests the presence of both alpha and beta adrenergic receptors see[r] ...
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