Beta-Catenin
FOXC1 induces cancer stem cell-like properties through upregulation of beta-catenin in NSCLC
... promotes beta-catenin expression by enhancing the activity of beta-catenin ...in beta-catenin mRNA, GSK3 β , pGSK3 β and total and nuclear beta-catenin protein ...
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Original Article Berberine inhibits cell growth via Wnt/beta-catenin signaling in glioma
... Wif-1 silencing may be an early epigenetically carcinogenic event and plays a role in tumor development and progression [7-9]. Herein, we hypothesize that berberine may be used as an effective and nontoxic demethylating ...
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Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway
... Several studies have presented evidence for a protec- tive role of PPAR gamma against cancer. In colon cancer, PPAR gamma downregulates the oncogene beta-catenin and suppresses cell proliferation [98]. In ...
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Evaluation of myosin VI, E-cadherin and beta-catenin immunostaining in renal cell carcinoma
... and beta-catenin and participates in border cell migration where it stabilises the E-cad- herin-beta-catenin cell adhesion complex ...unknown. Beta-catenin, however, can be ...
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The inhibition of microRNAs by HIV 1 Tat suppresses beta catenin activity in astrocytes
... on beta-catenin and the involvement of miRNAs, we performed a β-catenin responsive reporter gene assay to look at the β-catenin activity in an astro- cyte cell line, U-87MG ...
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CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway
... We do acknowledge that some limitations exist in our study. For instance, we only included one CRC cell line for our laboratory study, which may result in cell line bias. In addition, the sample size of our clinical ...
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EXPRESSION OF LGR5 AND BETA-CATENIN IN BENIGN AND MALIGNANT COLORECTAL LESIONS IN ZAGAZIG UNIVERSITY HOSPITAL.
... and in hepatocellular carcinomas (37) . However, our results showed that there was no statistical significant relation between Lgr5 and Beta-catenin expression in benign and malignant colorectal lesions. ...
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<p>ZNF671 Inhibits the Proliferation and Metastasis of NSCLC via the Wnt/β-Catenin Pathway</p>
... of beta catenin CTNNB1) and PID_BETA_CATAENIN_NUC_PATHWAY (Regulation of nuclear beta catenin signaling and target gene tran- scription) gene signatures in gene expression pro fi les of lung ...
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Study of immunohistochemical expression of beta-catenin in thyroid tumors and its correlation with histopathology
... The morphological distinction of thyroid follicular lesions can sometimes be a challenging one for the pathologists, and therefore an immunohistochemical marker can be useful . Beta catenin is one such ...
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Studies of the Wnt/Beta-catenin signalling pathway in chronic myeloid leukaemia
... Beta-catenin is a non-enzymatic 781 amino acid protein encoded by the CTNNB1 gene which plays a crucial role in both cell adhesion and Wnt signalling. There are various parts of the β-catenin ...
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P53 and Beta-Catenin Activity during Estrogen treatment of Osteoblasts
... Estrogen affects osteoblasts by non genotropic mecha- nisms that go to increase the life span of the osteoblasts by its action on plasma membrane signaling proteins [31]. Antiapoptotic mechanism by estrogen is transient ...
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E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway
... Cell lysate preparation and immunoblot analysis were performed according to established protocols [25]. A radioimmunoprecipitation buffer (Solarbio, Beijing, China), containing a protease inhibitor cocktail (Roche ...
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β-Catenin promotes cell proliferation, migration, and invasion but induces apoptosis in renal cell carcinoma
... Total protein was extracted from cells using ice-cold radio immunoprecipitation assay buffer (RIPA; Beyotime Institute of Biotechnology, Shanghai, China) containing 0.01% pro- tease and phosphatase inhibitor (Sigma, ...
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Identification of genes regulated by Wnt/beta catenin pathway and involved in apoptosis via microarray analysis
... It is well known that Wnt/β-catenin pathway regulates the transcription of a suite of genes controlling numerous aspects of development and human diseases, ranging from cellular proliferation, differentiation and ...
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Genome-wide occupancy links Hoxa2 to Wnt-beta-catenin signaling in mouse embryonic development
... The regulation of gene expression is central to de- velopmental programs and largely depends on the binding of sequence-specific transcription factors with cis-regulatory elements in the genome. Hox transcription factors ...
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Differential expression of E-cadherin, N-cadherin and beta-catenin in proximal and distal segments of the rat nephron.
... utes in the secondary antibodies, a TRITC-conjugated goat anti-mouse IgG (Sigma #T5393) and a FITC-conjugated goat anti-rabbit IgG (Sigma #F0382). Samples were then rinsed, mounted and viewed as described previously. For ...
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Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression
... I will now discuss alternative mechanisms that may result in nuclear β-catenin signalling in cancer cells in the absence of overexpressed Wnt ligands or mutational acti- vation in the canonical ...
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DcR3 induces proliferation, migration, invasion, and EMT in gastric cancer cells via the PI3K/AKT/GSK-3β/β-catenin signaling pathway
... To confirm the importance of DcR3 on PI3K/AKT/ GSK-3 β / β -catenin signaling, the HGC27 and MKN28 cells were treated with PI3K inhibitor LY294002 (50 µ M) for 24 hours, and dimethyl sulfoxide was used as control. ...
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<p>CK19 Promotes Ovarian Cancer Development by Impacting on Wnt/β-Catenin Pathway</p>
... Proteins were extracted following the manufacturer ’ s instructions using the protein extraction kit (Beyotime Institute of Biotechnology, Haimen, China). Protein con- centrations were determined by the BCA Protein ...
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<p>Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway</p>
... In conclusion, this study supported the therapeutic effect of HBO therapy on neuronal apoptosis after acute TBI. More- over, this study primarily verified the role played by the Akt/ GSK3 β / β -catenin pathway in ...
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