Beta catenin signaling
MiR 92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta catenin signaling pathway
... Wnt/beta-catenin signaling path- way, such as Bcl2, c-myc, c-Jun and ...of beta-catenin (Figure 4A), which suggested that miR-92b modulated beta-catenin via ...
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Original Article Berberine inhibits cell growth via Wnt/beta-catenin signaling in glioma
... Wnt/beta-catenin signaling pathway is associated with ...Wnt/beta-catenin signaling pathway in growth of glioma cells in ...Wnt/beta-catenin signaling ...
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Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells
... WNT-beta-catenin signaling is one of the most con- served signaling pathways that is critical for the develop- ment and regeneration of various ...cancers. Beta-catenin is the ...
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<p>Nr5a2 promotes tumor growth and metastasis of gastric cancer AGS cells by Wnt/beta-catenin signaling</p>
... Wnt/beta-catenin signaling pathway plays an important role in maintaining an epithelial cell phenotype, 36 and pre- vious studies have reported that Nr5a2 could drive cell cycle progression and ...
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CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway
... Wnt signaling pathway was activated and EMT was in- duced when CLCA1 was ...Wnt signaling specific inhibitor, ...Wnt/ beta-catenin signaling pathway and ...
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Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance
... ing begin when extracellular Wnt ligands bind to receptors on the cell membrane. In the canonical pathway, binding of Wnt ligands to the transmembrane receptor’s Wnt/FZD- related protein and to the low-density ...
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<p>Dihydrotanshinone I inhibits the growth of osteosarcoma through the Wnt/β-catenin signaling pathway</p>
... improved the survival rate of osteosarcoma patients to a certain extent, 17 but various uncontrollable factors or poten- tial side effects make these treatments unsatisfactory. 18 Herbal and natural products have been ...
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Wnt/beta catenin signaling in embryonic stem cell converted tumor cells
... inhibitor of mitogen-activated protein kinase signaling which induces differentiation of ESCs [30]. The 2i medium was first applied to derive mouse ESCs [25]. In this study, we applied 2i medium to derive and ...
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<p>New Advances in Canonical Wnt/β-Catenin Signaling in Cancer</p>
... Wnt signaling and promoting the malignant progression of breast ...Wnt/β-catenin signaling is, therefore, a key to the treatment of breast cancer, although it is difficult to specifically control the ...
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Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma
... and signaling pathways, in which Wnt/b-catenin signaling has been pro- posed to be critical ...Wnt/b-catenin signaling is a major feature ...
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The critical role of EGF-β-catenin signaling in the epithelial-mesenchymal transition in human glioblastoma
... Notes: inhibition of the Pi3K/aKT signaling pathways by chemical inhibitors lY294002 (40 mM) was conducted. egF-induced U87 cells were pretreated for 1 h with DMsO alone or 40 mM of lY294002, and then cultured in ...
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Genome-wide occupancy links Hoxa2 to Wnt-beta-catenin signaling in mouse embryonic development
... Wnt–b-catenin signaling remains highly active in the outer ear outgrowth, which fails to form in the Hoxa2 ...Wnt–b-catenin signaling controls morphogenesis of the outer ear downstream of ...
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LncRNA CASC11 promotes the cervical cancer progression by activating Wnt/beta-catenin signaling pathway
... Materials: Quantitative real-time polymerase chain reaction (RT-qPCR) was used to detect the expressions of CASC11 in cancerous and adjacent normal tissues of patients with cervical cancer as well as in cell lines. The ...
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Discovery of Novel Small Molecule Activators of beta-Catenin Signaling
... these cells with 12 nM recombinant mouse Wnt-3a (rmWnt-3a) and 30 mM lithium chloride (LiCl) (Figure 1C). Wnt-3a is a naturally occurring Wnt ligand that activates Wnt/b-catenin signaling in several ...
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ABERRANT EXPRESSION OF WNT/BETA CATENIN SIGNALING PATHWAY AND IN VITRO CYTOTOXIC ACTIVITY OF TRADESCANTIA SPATHACEA MEDICINAL PLANT USED TO TREAT HUMAN BREAST ADENOCARCINOMA (MCF 7 CELL LINES)
... homologous protein called as armadillo. β-catenin protein involved both of transcriptional activation and cell-cell adhesion. A Wnt gene (Wnt1) was first discovered in mouse mammary tumor 12, 13 . Wnt ...
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Novel mutation G324C in WNT1 mapped in a large Pakistani family with severe recessively inherited Osteogenesis Imperfecta
... induced beta-catenin signaling ...the signaling pathway have been reported also in other disorders with abnormal bone mass, suggest- ing that the pathway has an integral role in the regulation ...
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Original Article MicroRNA-374a promotes osteogenic differentiation of periodontal ligament stem cells through directly targeting APC/Wnt/β-catenin signaling pathway
... Total cellular proteins were extracted using RIPA lysis buffer containing proteinase inhibitor (Sigma, USA). Equal amounts of total protein were loaded into a 10% SDS-PAGE transferred onto a PVDF membrane probed with ...
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The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytes
... Firstly, we tested if S27D affected the viability of the endothelial cells. Using flow cytometry to measure Annexin-V binding, a marker for early apoptosis, we found that the majority of the endothelial cells (77%) were ...
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A review on the diagnosis and treatment of hepatocellular carcinoma with a focus on the role of Wnts and the dickkopf family of Wnt inhibitors
... Notes: (A) in the absence of wnts, β-catenin is ubiquitinated and targeted for degradation by a protein complex that consists of adenomatous polyposis coli, axin, and glycogen synthase kinase 3β. (B) wnts bind ...
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Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
... factor beta; Th17: T helper 17 cell; TNKS: Tankyrase; Treg: Regulatory T cells; VEGF: Vascular endothelial growth factor; YY1: Ying Yang1; Znrf3: Zinc and ring finger ...
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