Beta-cell function
Pancreatic fat deposition is increased and related to beta-cell function in women with familial partial lipodystrophy
... investigate beta-cell function, the hyperglycemic clamp method, was substituted by OGTT, which is widely used as well in literature and provides valuable information of “residual” ...
6
<p>Beta-cell function in type 2 diabetic patients who failed to maintain good glycemic status with a combination of maximum dosages of metformin and sulfonylurea</p>
... either beta-cell function or beta-cell number, or both, that related to the deterioration of beta-cells along the natural course of T2DM or the deleterious effect of SU per se on ...
10
Relationships of pancreatic beta-cell function with microalbuminuria and glomerular filtration rate in middle-aged and elderly population without type 2 diabetes mellitus: a Chinese community-based analysis
... pancreatic beta-cell function, we calculated the homeostasis model assessment-beta (HOMA-beta) index using the following formula (with glucose and insulin levels as indicated earlier): ...
5
Effect of protein glycation by methylglyoxal on pancreatic beta cell function
... on beta cells and involvement in early stage dysfunction and development of type 2 diabetes mellitus are not ...on beta cell function and related involvement in the development of ...of ...
232
<p>Sitagliptin Increases Beta-Cell Function and Decreases Insulin Resistance in Newly Diagnosed Vietnamese Patients with Type 2 Diabetes Mellitus</p>
... in beta-cell function resulting in high postprandial blood glucose and the development to chronic diabetic complications occurs at an early stage of the ...increases beta-cell ...
9
Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors
... measured by glucose potentiation of arginine-induced insulin secretion, was significantly decreased in donors (maximal acute insulin response [AIRmax]: donors = 666 +/- 84 pM vs controls = 1,772 +/- 234 pM) while the ...
7
The association of depression and perceived stress with beta cell function between African and Haitian Americans with and without type 2 diabetes
... for beta cell dysfunction and ...with beta cell func- tion between African and Haitian Americans with and without type 2 ...calculate beta cell ...
8
The Role of OATP-Mediated Statin Transport in Pancreatic Beta Cell Function
... hepatocyte function, is essential for hepatic gene expression and lipid homeostasis (Hayhurst et ...β cell-failure. Moreover, islets of mice with β-cell specific deficiency of Hnf4a showed impaired ...
148
Impaired pancreatic beta cell function in the fetal GK rat Impact of diabetic inheritance
... b cell mass (3), hepatic glucose overproduction, and moderate peripheral insulin resistance in muscles and adipose tissues ...b cell defects in the etiology of NIDDM in the GK ...b cell mass (7), it ...
7
Interaction of Fat stimulated Gastric Inhibitory Polypeptide on Pancreatic Alpha and Beta Cell Function
... Under euglycemic clamp conditions plasma glucose, 89±1 mg/dl and physiologic hyperinsulinemia serum immunoreactive insulin, 137±3 ,uU/ml GIP responses to fat ingestion 39.7±9.8 ng/ml per[r] ...
8
Therapeutic concentrations of antidepressants inhibit pancreatic beta cell function via mitochondrial complex inhibition
... plasma concentration for these ADs are well established to be related to dose (Reis et al., 2009), a daily fluoxetine dose of 80 mg can yield steady state plasma concentrations >2 µM (Lundmark et al., 2001), a ...
43
Beta-cell function is associated with metabolic syndrome in Mexican subjects
... -cell function, decreased IS, an increased IR in subjects at metabolic balance without metabolic syndrome, and the progressive deterioration of β -cell function and IS in subjects with ...
9
Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
... Elevations in the ratio of proinsulin to insulin, as well as in absolute proinsulin concentrations adjusted for fasting insulin, have been postulated as early markers of b-cell dysfunction [26]. However, ...
10
A Cross-Sectional Study of Glycemic Status and Zinc Level in Patients with Beta-Thalassemia Major
... The beta-cell function correlated significantly with iron overload indicators such as serum ferritin and total units of blood transfusion in our study ...receptor function and intracellular ...
8
A New Fuzzy Control Model for Kidney Patients
... pancreatic beta cell or beta cell function, BMI, length of dialysis before transplantation, systolic and diastolic blood pressure be- fore and after the ...
5
Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat
... of beta-cell function (HOMA-B) and insulin sensitivity (HOMA-IR) in [ 35,000 participants (Dupuis et ...and beta-cell function, but only two with HOMA-IR or fasting insulin as a ...
8
The Role of c-Kit Receptor Tyrosine Kinase in Beta-Cell Proliferation, Function and Survival
... Increased beta-cell workload could result in an increase of misfolded protein production, and activation of the unfolded protein response in the ER and Golgi apparatus [38, ...trigger ...
267
The effect of insulin administration on c-peptide in critically ill patients with type 2 diabetes
... physiological beta-cell function during acute illness may be a desirable physiological and clinical ...the beta-cell response during permissive, stress-induced hyperglycemia in ...
8
PROTECTIVE EFFECT OF ETHANOLIC EXTRACT AND FRESH JUICE OF CASSIA AURICULATA LINN ON THE BLOOD SUGAR OF ALBINO RATS
... According to theory, the hypoglycemic plants act through a variety of mechanisms such as improving insulin sensitivity, augment in glucose dependent insulin secretion and stimulating the regeneration of islets of ...
14
CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells
... affects beta-cell function, the influ- ence of CFTR on insulin secretion was measured from isolated human and mouse pancreatic islets subjected to glucose-induced insulin secretion ...complementary ...
12