beta-lactam
Beta-lactam vs Non-Beta-Lactam for the Empiric Treatment of Gram Negative Bloodstream Infections
... Background: Historically studies evaluating treatment outcomes for patients with gram negative bacilli (GNB) bloodstream infections (BSI) have been between two beta-lactams. The objective of this study is to ...
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Optimization of the treatment with beta lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)
... ICU patients in the early phase of severe sepsis and sep- tic shock, Taccone et al. observed that PK-PD targets were achieved in only 28%, 16%, and 44% of patients treated with ceftazidime, cefepime, and piperacillin, ...
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Continuous beta-lactam infusion in critically ill patients: the clinical evidence
... Most of the studies included in the three meta-analyses utilized higher IB doses than the CI treatment arm, po- tentially favoring the former [76-79,81,84,86,87] (Table 3). This treatment bias might have skewed the ...
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Haemophilus influenzae with Non Beta Lactamase Mediated Beta Lactam Resistance: Easy To Find but Hard To Categorize
... (4/49) ME with M.I.C.E. and 6.1% (3/49) with Etest (21). In con- trast, and consistent with the observations in the present study, Barry et al. tested 143 bla-negative H. influenzae isolates and found a higher ampicillin ...
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Daptomycin versus placebo as an adjunct to beta lactam therapy in the treatment of Staphylococcus aureus bacteremia: study protocol for a randomized controlled trial
... Methods: The DASH-RCT trial is a randomized, double blind, placebo-controlled trial designed per the Standard Protocol Items: Recommendation for Interventional Trials (SPIRIT) and Consolidated Standards of Reporting ...
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Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric population
... of beta-lactam allergy there was a low rate of true allergy ...of beta-lactam allergy advised that they could safely re-introduce beta-lactam ...as beta-lactam ...
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Relative substrate affinity index values: a method for identification of beta lactamase enzymes and prediction of successful beta lactam therapy
... For ease of comparison of the affinity values of a specific beta-lactamase against different beta-lactam antibiotics, I propose the term relative substrate affinity index RSAI, which is [r] ...
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A Correlation of the Drug Activities (Anti-bacterial) in the Structure of Some Hetero Cyclic Compound Containing Benzimidazole and Beta-lactam Moiety in Terms of the Density Functional Descriptors – A QSAR and QSPR Study
... Present study shows the correlation of activity of as many as 13 Anti- bacterial (containing benzimidazole and beta-lactam moiety ) drugs in terms of global reactivity descriptors under paradigm of ...
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Impact of the New Delhi metallo-beta-lactamase on beta-lactam antibiotics
... the world in areas such as the UK and the Middle East. The clinical cases outlined in Table 1 also help demonstrate the wide spread of NDM producers. A variety of non-beta-lactam antimicrobials are ...
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Single enantiomer synthesis of alpha (trifluoromethyl) beta lactam
... commercially available source of the CF 3 group. It was envis- aged that conjugate addition of an enantiomerically pure amide such as (R)- or (S)-3 would generate the addition adducts, carboxylate salts 4, as a mixture ...
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Characterisation of the cellular basis of beta-lactam induced skin and liver injury
... 143 responses and delineate the key “switches” that determine whether drug exposure will be associated with the development of a hypersensitive or tolerant response. Patient samples are being collected prior to a ...
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How beta lactam antibiotics enter bacteria: a dialogue with the porins
... In this study transport properties through a major E. aerogenes porin, Omp36 (homologous to E. coli OmpC and to Klebsiella pneumoniae OmpK36) were investigated. Physiological conditions within the patient body favor the ...
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Are third-generation cephalosporins unavoidable for empirical therapy of community-acquired pneumonia in adult patients who require ICU admission? A retrospective study
... In our retrospective study, we evaluated the efficacy and relevance of the chosen empirical antibiotic therapy especially non-antipseudomonal 3GCs in the light of the microbiologically identified pathogens and their ...
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Cost effectiveness of antibiotic treatment strategies for community acquired pneumonia: results from a cluster randomized cross over trial
... monotherapy, beta-lactam/macrolide combination therapy or fluoro- quinolone monotherapy) was the preferred empirical treatment for adult patients hospitalized to non- intensive care unit (ICU) wards with a ...
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Microbiological characteristics of sepsis in a University hospital
... to beta-lactam and quinolones drugs, require- ment for the rapid transmission of information from microbiology laboratories such as the results of the Gram stain, the antibiogram, determining the minimum ...
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Faecal colonization of E coli and Klebsiella spp producing extended spectrum beta lactamases and plasmid mediated AmpC in Mozambican university students
... Genomic DNA was isolated and purified using the GeneJet Genomic DNA Purification Kit (Thermo Scientific, USA). Antibiotic-susceptible E. coli ATCC 25922 and beta-lactam resistant SHV-18 K. pneumo- niae ATCC ...
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Molecular detection of SHV-Type ESBL in E. coli and K.pneumoniae and their antimicrobial resistance profile
... of Beta-lactam resistance in Gram-negative bacteria has become a main clinical problem worldwide that limits therapeutic ...newer beta-lactam antibiotics in ...
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<p>Combined administration of antibiotics increases the incidence of antibiotic-associated diarrhea in critically ill patients</p>
... and beta-lactam plus enzyme inhibitor antibiotics (or sequential use of both antibiotics), and combinations including beta- lactam plus enzyme inhibitor antibiotics increased the occurrence of ...
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Quantitative evaluation of surface water pollution by antibiotic residues in Yaounde of Cameroon
... Antibiotics such as beta-lactam antibiotics are rarely encountered in water because of their high solubility, yet they are present in the effluents of the STEP of the CNPS hospital and i[r] ...
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Comparison of the pharmacokinetic properties of vancomycin, linezolid, tigecyclin, and daptomycin
... Vancomycin is indicated for susceptible strains of me- thicillin-resistant (beta-lactam-resistant) staphylococci [4]. It is indicated for penicillin-allergic patients, for patie[r] ...
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