beta-lactam antibiotics
In silico analysis of penicillin binding protein 5 as an in hibitory target of beta lactam antibiotics in Enterococcus faecalis
... Enterococcus faecalis is a frequent cause of a wide diversity of infections in humans such as hospital and community-acquired infections, urinary tract infection (UTI), bacteremia, endocarditis, abdomen, biliary tract, ...
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Transport of beta lactam antibiotics in kidney brush border membrane Determinants of their affinity for the oligopeptide/H+ symporter
... whether beta-lactam antibiotics (cephalosporins and penicillins) are all substrates for the renal oligopeptide/H+ symporter and, if so, whether the transport system discriminates among the numerous ...
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Chemistry, classification, pharmacokinetics, clinical uses and analysis of beta lactam antibiotics: A review
... of beta- lactam antibiotics, does not induce beta-lactamase activity and its molecular structure confers a high degree of resistance to hydrolysis by beta-lactamases (ie, penicillinases ...
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Pharmacokinetics–pharmacodynamics issues relevant for the clinical use of beta lactam antibiotics in critically ill patients
... of beta-lactams in sepsis/septic shock, both in different pa- tients and in the same patient over ...of beta-lactams, TDM was thought unnecessary for these ...with beta-lactams has been reported in ...
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Comprehensive allergy work-up is mandatory in cystic fibrosis patients who report a history suggestive of drug allergy to beta-lactam antibiotics
... Cystic fibrosis (CF) is a chronic disease for which chronic therapies are required to slow the progression of disease [1]. Patients with CF suffer daily symptoms, fre- quent exacerbations of pulmonary infection, and an ...
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Comparison of Disc Diffusion, Broth Microdilution and Modified Hodge Test Susceptibility Testing Of Escherichia coli Isolates to Beta-Lactam Antibiotics
... carbapenem antibiotics and false-resistance or false-sensitive results in carbapenemase diagnostic test may be due to other mechanisms such as changes in the permeability of the outer membrane, ESBL enzymes, ...
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Effects of storage temperature and pH on the stability of eleven beta lactam antibiotics in MIC trays
... The three short-term prob lems with the -25°C freezer had no apparent effects on th e drugs stored there; no evidence of deterioration was detectacted in antimicrobial activity at the ti[r] ...
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Evaluation of broth disk elution methods for susceptibility testing of anaerobic bacteria with the newer beta lactam antibiotics
... The present study indicates that several versions of the disk elution test provide reasonable accuracy for testing of many anaerobe species with cefoperazone, cefotaxime, ceftazidime, ce[r] ...
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How beta lactam antibiotics enter bacteria: a dialogue with the porins
... biological susceptibility assays to explore b-lactam translocation properties through Omp36, a major porin of the MDR pathogen, E. aerogenes. Using two representative b-lactam molecules, we demonstrate that ...
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Impact of the New Delhi metallo-beta-lactamase on beta-lactam antibiotics
... carbapenem antibiotics as predicted by in vitro testing but other resis- tance mechanisms need to be present to generate a resistant ...and beta-lactamase inhibitor combinations, may retain utility against ...
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<p>Multilocus sequence typing and <em>bla</em><sub>ESBL</sub> characterization of extended-spectrum beta-lactamase-producing <em>Escherichia coli</em> isolated from healthy humans and swine in Northern Thailand</p>
... of antibiotics without prescriptions such as beta-lactams and fl uoroquinolones use for lower urinary tract ...of antibiotics in food animals contributes to selective pressures that promote AMR in ...
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Characterization of ceftriaxone-resistant Aeromonas spp. isolates from stool samples of both children and adults in Southern India
... countries where infections caused by Aeromonas is common. Organisms expressing AmpCBL is an important clinical concern since these isolates are usually resistant to all beta-lactam antibiotics except ...
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Molecular detection of SHV-Type ESBL in E. coli and K.pneumoniae and their antimicrobial resistance profile
... of Beta-lactam resistance in Gram-negative bacteria has become a main clinical problem worldwide that limits therapeutic ...newer beta-lactam antibiotics in ...
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Commentary: Impact of CLSI Breakpoint Changes on Microbiology Laboratories and Antimicrobial Stewardship Programs
... many beta-lactam antibiotics, including extended-spectrum cephalosporins, to enhance the de- tection of known resistance among Enterobacteriaceae (Table ...
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Relative substrate affinity index values: a method for identification of beta lactamase enzymes and prediction of successful beta lactam therapy
... For ease of comparison of the affinity values of a specific beta-lactamase against different beta-lactam antibiotics, I propose the term relative substrate affinity index RSAI, which is [r] ...
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Treatment of Gram negative pneumonia in the critical care setting: is the beta lactam antibiotic backbone broken beyond repair?
... give beta-lactam antibiotics by traditional intermittent bolus dosing or continuous ...of beta-lactam antibiotics should be advantageous, because it produces more sus- tained ...
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Emerging trends and persistent challenges in the management of adult syphilis
... to beta lactam antibiotics, tetracyclines and macrolides for reasons other than syphilis treatment, combined with the use of significantly more sensitive modern nontreponemal tests is ...
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Determination of the range of antibacterial activity by use of viable counts
... The activity of three aminoglycosides and six beta-lactam antibiotics on strains of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aur[r] ...
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Single enantiomer synthesis of alpha (trifluoromethyl) beta lactam
... stereogenic centre after the addition of D 2 O to the reaction on work up. The major and minor diastereoisomers of 5a were sep- arated by careful chromatography on silica gel into single stereoisomers. Completion of the ...
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Approaches to the biomimetic synthesis of β lactam antibiotics
... The mixture was stirred for 4 h , then the dichloromethane layer was separated, washed with water 3 x 50ml, dried MgS0 4 , and concentrated under reduced pressure to give white crystall[r] ...
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