Beta oxidation
Analysis of the role of COMATOSE and peroxisomal beta-oxidation in the determination of germination potential in Arabidopsis
... seeds, again highly influenced by G 3 E interactions (Bew- ley and Black, 1994; Farnsworth, 2000; Donohue et al., 2005). Therefore, in this paper, a physiological approach has been used to compare directly the dormancy ...
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Impaired mitochondrial beta oxidation in a patient with an abnormality of the respiratory chain Studies in skeletal muscle mitochondria
... neurological disease. We report studies that demonstrate a severe deficiency of complex I activity with less severe abnormalities of complexes III and IV (less than 5, 63, and 30% of control values, respectively) in a ...
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Metabolism of prostaglandin F2 alpha in Zellweger syndrome Peroxisomal beta oxidation is a major importance for in vivo degradation of prostaglandins in humans
... chromatography. The Zellweger patient was found to excrete prostaglandin metabolites considerably less polar than those of the control subjects. The major urinary metabolite in the control subjects was practically absent ...
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Reduction of n-3 PUFAs, specifically DHA and EPA, and enhancement of peroxisomal beta-oxidation in type 2 diabetic rat heart
... acid oxidation (FAO) to compensate for the diminished utilization of glucose, we hypothesize that T2DM hearts consume more n-3 PUFAs and, therefore, need more n-3 ...peroxisomal beta-oxidation, which ...
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Unraveling the Pathway of Lipid Oxidation in the Young Pig: Assessment of Hepatic beta-oxidation and Characterization of Carnitine Palmitoyltransferase I (CPT I)
... arising from different genes. One of the first distinguishable attributes of CPT I in comparison to CPT II is the loss of activity following treatment of mitochondria with detergents (McGarry et al., 1978). The loss of ...
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A novel approach to target hypoxic cancer cells via combining β-oxidation inhibitor etomoxir with radiation
... Subsequently, we confirmed the efficacy of radiation and etomoxir combination to reduce sphere growth in human PCa LNCaP cells. As shown in Figure 5A, radiation alone reduced the sphere number by 39.2% (p < 0.05), ...
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Hydroxyeicosatetraenoic acid metabolism in cultured human skin fibroblasts Evidence for peroxisomal beta oxidation
... (HETE) oxidation, 12- and 15-HETE oxidation was measured in normal and peroxisomal deficient skin fibroblasts from patients with Zellweger's (cerebrohepatorenal) ...
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Chewing the fat: beta-oxidation in signalling and development
... (OPR3), the only OPR isoform with the correct stereospecificity 52,53 . opr3 mutant plants are JA deficient and exhibit male sterility, confirming the lack of redundancy for this step 54,55 . It is not yet clear which JA ...
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Chlamydomonas carries out fatty acid beta-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase
... The b -oxidation of fatty acids (FAs) plays a pivotal role in eukaryotic cells. This catabolic pathway generates acetyl- CoAs via breakdown of FAs acquired from the environment or released upon hydrolysis of ...
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Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion
... causing calcium influx through voltage-gated chan- nels, which finally triggers insulin secretion (12, 13). Defects causing HI increase ATP production by increasing glucose or glutamate metabolism, or they cause ...
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Acyl-CoA synthetase isoform 1 deficiency impairs beta-oxidation in mouse heart and adipose tissue
... Dysfunctional lipid metabolism underlies the development of obesity and obesity-related complications such as hepatic steatosis, diabetes, and heart disease. Although the mechanisms that regulate the cellular uptake, ...
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Oxidation of pristanic acid in fibroblasts and its application to the diagnosis of peroxisomal beta oxidation defects
... To our knowledge, this has been the first time that b-oxida- tion of a branched chain fatty acid has been used for comple- mentation analyses on patients with peroxisomal disorders. We feel the technique has particular ...
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Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency
... mitochondrial beta-oxidation of fatty acids through increased CPT2 activ- ity, consistent with previous results of Bonnefont et ...acid oxidation in the presence of mitochondrial stress arising from ...
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Peroxisomal bifunctional enzyme deficiency
... Peroxisomal function was evaluated in a male infant with clinical features of neonatal adrenoleukodystrophy. Very long chain fatty acid levels were elevated in both plasma and fibroblasts, and ...
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Bioinformatics for the NuGO proof of principle study: analysis of gene expression in muscle of ApoE3*Leiden mice on a high-fat diet using PathVisio
... Most genes present in the Mus musculus fatty acid beta oxidation 1 pathway (see Fig. 1 and http://wikipathways. org) are significantly downregulated after 12 weeks of HF feeding in muscle of ApoE3*Leiden ...
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Maternal diet deficient in riboflavin induces embryonic death associated with alterations in the hepatic proteome of duck embryos
... acid beta-oxidation, amino acid degradation, and electron transport chain (ETC), among others [1, ...the beta-oxidation of lipids was severely impaired in RD embryos, as indicated by the ...
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Sexual dimorphism in myocardial acylcarnitine and triglyceride metabolism
... In summary, these observations represent the first such report of sex differences in AC and TG metabolism as a potential metabolic signature of diabetes, which may contribute to downstream derangements in cardiac func- ...
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MILDRONATE: AN ANTIISCHEMIC DRUG WITH MULTIPLE INDICATIONS
... acid beta- oxidation in ischemic tissues and to block this highly oxygen- consuming ...acid beta- oxidation in ischemic tissues and to block this highly oxygen-consuming ...
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<p>Self-Renewal Signalling Pathway Inhibitors: Perspectives on Therapeutic Approaches for Cancer Stem Cells</p>
... The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors. JAK/STAT3-regulated fatty acid beta-oxidation is critical fo[r] ...
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Clonorchis sinensis acetoacetyl CoA thiolase: identification and characterization of its potential role in surviving in the bile duct
... Eukaryotic thiolases have key roles in many vital bio- chemical pathways, including the beta oxidation pathway of fatty acid degradation and various biosynthetic path- ways. Thiolase of Caenorhabditis ...
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