BFU-E
Soluble factor(s) produced by adult bone marrow stroma inhibit in vitro proliferation and differentiation of fetal liver BFU E by inducing apoptosis
... FL BFU-E is mediated by soluble factor(s) produced by ABM stroma but not contact ...FL BFU-E. Growth of FL BFU-E is equally inhibited by co- culture with FBM ...
10
A monokine stimulates production of human erythroid burst promoting activity by endothelial cells in vitro
... Abbreviations used in this paper: BFU-E, burst forming units erythroid; BPA, erythroid burst-promoting activity; ECCM, endothelial cell conditioned medium; ECCMM, conditioned medium from[r] ...
5
A Capsid-Modified Helper-Dependent Adenovirus Vector Containing the β-Globin Locus Control Region Displays a Nonrandom Integration Pattern and Allows Stable, Erythroid-Specific Gene Expression
... Ad.LCR: new features. (i) Ad.LCR vectors possess Ad35 fiber knobs. Previous studies have shown that this allows tar- geting of human bone marrow-derived cells with potential stem cell capacity, including CD34 ⫹ C-Kit ⫹ , ...
15
Synthesis of hemoglobin F in adult simian erythroid progenitor derived colonies
... The simian hematopoietic system is known to respond to anemic stress with the production of erythrocytes containing large amounts of fetal hemoglobin. To determine the regulatory mechanism responsible for hemoglobin F ...
11
Hypoxia with Wharton’s jelly mesenchymal stem cell coculture maintains stemness of umbilical cord blood-derived CD34+ cells
... BFU-E: Burst-forming unit-erythroid; CFC: Colony-forming cell; CFU: Colony- forming unit; CFU-GM: Colony-forming unit-granulocyte/macrophage; EPHOSS: Extraphysiologic oxygen shock/stress; G-CSF: Granulocyte ...
11
Human T cell leukemia virus I associated T suppressor cell inhibition of erythropoiesis in a patient with pure red cell aplasia and chronic T gamma lymphoproliferative disease
... progenitors (BFU-E) were 17 +/- 9% of control and were selectively increased to 88-102% of control after marrow T cell depletion. Patient Leu 2+ suppressor T cells spontaneously produced high titers of ...
12
Purification of human erythroid colony forming units and demonstration of specific binding of erythropoietin
... Morphological and biochemical studies of human colony-forming units-erythroid (CFU-E) have been hindered by their extreme rarity. Since burst-forming units-erythroid (BFU-E) develop into ...
11
Resistance to Friend Virus-Induced Erythroleukemia in W/Wv Mice Is Caused by a Spleen-Specific Defect Which Results in a Severe Reduction in Target Cells and a Lack of Sf-Stk Expression
... Friend virus induces erythroleukemia by co-opting the ery- throid differentiation machinery. The Kit/SCF signaling path- way regulates the expansion of erythroid progenitors and is thought to function primarily during ...
9
NOS2 deficiency has no influence on the radiosensitivity of the hematopoietic system
... cells; BFU-E: burst-forming unit erythroid; CFU-GM: colony forming unit-granulocyte, macrophage; CFU-GEMM: colony forming unit-granulocyte, erythroid, macrophage, megakaryocyte; CAFC: cobblestone ...
11
CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia
... We further investigated the effect of our engineered T cells on the colony-forming ability of CD34-enriched normal cord blood (CB) samples. After 4-h co-culture of CD34 + HSCs and CAR-T cells, each well was diluted in ...
13
Murine erythroid short term radioprotection requires a BMP4 dependent, self renewing population of stress erythroid progenitors
... (G–I) BFU-E colony-form- ing potential of Population I cells (G) and CFU-E colony-forming potential of Population I (H) and Population II (I) cells isolated by FACS from the spleens of mice ...
14
Characterization of menstrual stem cells: angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells
... bFGF: basic fibroblast growth factor; BFU-E: burst-forming unit-erythroid; BM: bone marrow; BM-MSCs: bone marrow derived mesenchymal stem cells; BSA: bovine serum albumin; CFU-F: fibrobl[r] ...
14
Cell-Mediated Lysis of human hematopoietic progenitor jcells.
... As shown in Fig 2, by usmg effector-target ratios varying from 1 2 to 4 1 the anti-A2-CTL line effectively inhibited the growth of CFU-GM, BFU-E, and CFU-GEMM of A2- positive bone marrow[r] ...
5
Effect of parathyroid hormone on erythropoiesis
... progenitors (CFU-GM), and evaluate the interaction between PTH and erythropoietin (Ep) on human BFU-E. Intact PTH (1-84 bPTH) in concentrations (7.5-30 U/ml;) comparable to those found in blood of uremic ...
8
Acetylated lipoproteins impair erythroid growth factor release from endothelial cells
... Abbreviations used in this paper: AcLDL, acetylated low density lipoproteins; BAEC, bovine aortic endothelial cells; BFU-E, burstforming unit-erythroid; BPA, erythroid burst-promoting ac[r] ...
11
Mesenchymal stem cells promote a primitive phenotype CD34+c-kit+ in human cord blood-derived hematopoietic stem cells during ex vivo expansion
... The CD117 or c-kit, characterized by Yarden et al. in 1987 [29], is expressed in hematopoietic cells and also in several non-hematopoietic tissues and tumors [30]. Together with CD33 and HLA-DR, it has been used for ...
23
Inhibition of human colony forming unit erythroid by tumor necrosis factor requires accessory cells
... Recombinant tumor necrosis factor (rTNF) inhibits erythropoiesis in vivo and in vitro. To study the mechanism of this inhibition, the effect of rTNF on highly purified human CFU- erythroid (E) (mean purity 63.5%), ...
5
Retrovirus induced feline pure red cell aplasia Hematopoietic progenitors are infected with feline leukemia virus and erythroid burst forming cells are uniquely sensitive to heterologous complement
... of BFU-E alone did not result in ...that BFU-E from cats with PRCA were unusually sensitive to C' alone, without the addition of ...to BFU-E and not a property of CFU-E, ...
9
Simian immunodeficiency virus inhibits bone marrow hematopoietic progenitor cell growth.
... Bone marrow hematopoietic progenitor cell colony formation, both granulocyte/ macrophage CFU-GM and erythrocyte BFU-E, was shown to be decreased in number in SIVmac-infected rhesus monke[r] ...
8
Interleukin 1 induces cultured human endothelial cell production of granulocyte macrophage colony stimulating factor
... Abbreviations used in this paper: BFU E, erythroid burst-forming unit; BPA, burst-promoting activity; CFU E, erythroid colony-forming unit; CFU GM, granulocyte-macrophage colony-forming [r] ...
5