Biliary Cholesterol
Biliary cholesterol secretion by the twinned sterol half transporters ABCG5 and ABCG8
... the cholesterol apex of the ...of cholesterol and lecithin into the canalicular bile has become uncoupled and supports the notion that the phospholipid content in the bile limits the rate of ...
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Multicompartmental Analysis of Cholesterol Metabolism in Man: CHARACTERIZATION OF THE HEPATIC BILE ACID AND BILIARY CHOLESTEROL PRECURSOR SITES
... hepatic cholesterol precursor sites associated with the formation and secretion of bile acids and biliary ...their cholesterol from newly synthesized and lipoprotein free ...of cholesterol ...
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THE RELATION OF PLASMA AND BILIARY CHOLESTEROL TO BILE ACID SYNTHESIS IN MAN
... A similar elevation in the specific activity of biliary cholesterol as compared with plasma cholesterol was reported by Gould and coworkers who administered labeled acetate to dogs with [r] ...
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Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
... promote biliary sterol excretion in ...liver cholesterol levels but profoundly altered cholesterol ...dietary cholesterol was reduced by about 50%, and biliary cholesterol levels ...
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Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism Evidence for a distinct biliary precursor pool
... decreased biliary cholesterol secretion ...increased biliary cholesterol output 32% at 1 ...on biliary bile salt or phospholipid ...
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Regulation of biliary cholesterol secretion in the rat Role of hepatic cholesterol esterification
... hepatic cholesterol synthesis and esterification were measured in isolated ...synthesized cholesterol to total biliary cholesterol output was only 19 +/- 9%, compared with 12 +/- 6% in control ...
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Regulation of biliary cholesterol secretion Functional relationship between the canalicular and sinusoidal cholesterol secretory pathways in the rat
... between biliary cholesterol secretion, sinusoidal lipoprotein cholesterol secretion and bile salt synthesis was studied in the ...influence biliary cholesterol output, VLDL production ...
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ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice
... of cholesterol from ...excess cholesterol in macrophages, lead to the formation of fatty streaks, complex lesions, and even- tually plaque rupture ...macrophage cholesterol efflux by enhanced ABCA1 ...
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Inappropriate hepatic cholesterol synthesis expands the cellular pool of sterol available for recruitment by bile acids in the rat
... excessive biliary cholesterol secretion is a level of hepatic sterol synthesis that is inappropriately high relative to the needs of the liver cell for preserving cholesterol ...balance. ...
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Biliary lipid secretion and bile composition after acute and chronic interruption of the enterohepatic circulation in the rhesus monkey: IV Primate biliary physiology
... Bile salts and phospholipids are both required to solubilize biliary cholesterol. Since interruption of the enterohepatic circulation (EHC) depletes bile of bile salts, we have examined in the rhesus monkey ...
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Mechanism of secretion of biliary lipids I Role of bile canalicular and microsomal membranes in the synthesis and transport of biliary lecithin and cholesterol
... and biliary cholesterol followed a pattern similar to that for ...(a) biliary lecithin and cholesterol are derived from a microsomal subpool regulated by the flux of enterohepatic bile acids, ...
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Influence of Flaxseed on Some Biochemical Factors, Antioxidant Activity and Expression of ABCG5 and ABCG8 Genes in the Liver of Diabetic Rat
... of cholesterol is controlled by a several ways including: intestinal absorption, de novo synthesis, biliary clearance and also faecal elimination of ...cholesterol. Biliary clearance has been ...
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Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... HDL cholesterol and increased biliary cholesterol, but not bile acid or phospholipid, ...of cholesterol from plasma HDL to the bile for excretion (Figure ...total cholesterol is ...
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Effects of polyunsaturated fats on lipid metabolism in patients with hypertriglyceridemia
... of biliary cholesterol, and frequently there was an increase in fecal neutral steroids that were derived from cholesterol; thus, polyunsaturated fats may increase bile lithogenicity in some patients ...
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Mechanisms of gallstone formation in women Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism
... altered biliary bile acid composition [( CA + DCA]/CDCA increases, P less than ...stimulated cholesterol esterification (P less than ...dietary cholesterol stimulated the biliary secretion of ...
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Molecular processes that handle — and mishandle — dietary lipids
... intestinal cholesterol absorption, decreased expression of Npc1l1 (28) and decreased hepatic biliary cholesterol excretion, and increased intestinal expression of ABCG5/G8 (28–30) cholesterol ...
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Effects of dietary cholesterol on cholesterol and bile acid homeostasis in patients with cholesterol gallstones
... high cholesterol, the fraction of cholesterol absorbed decreased in both groups and cholesterol synthesis decreased, especially in the gallstone ...group. Biliary cholesterol secretion ...
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Effects of lovastatin and dietary cholesterol on sterol homeostasis in healthy human subjects
... dietary cholesterol for any parameter ...lower cholesterol synthesis and systemic cholesterol input, the main compensatory response being reduced biliary cholesterol ...dietary ...
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Biliary excretion of lecithin and cholesterol in the dog
... or cholesterol excretion and SC2644 (which caused a marked increase in canalicular bile production as measured by erythritol clearance) caused a depression of lipid ...
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Lack of P2Y13 in mice fed a high cholesterol diet results in decreased hepatic cholesterol content, biliary lipid secretion and reverse cholesterol transport
... apical biliary choles- terol secretion ...as biliary phospholipid transport protein (Abcb4/mdr3), bile salt export pump (Abcb11/bsep), basolateral transporter sodium taurocholate cotransporting polypeptide ...
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