Biliary tract
<p>Biliary tract cancers: current knowledge, clinical candidates and future challenges</p>
... advanced biliary tract cancer; aCCA, advanced cholangiocarcinoma; αKGDH, α-ketoglutarate dehydrogenase; BTC, biliary tract cancer; Bcr- abl, bcr-abl fusion oncogene/Philadelphia chromosome; ...
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Tumor growth effects of rapamycin on human biliary tract cancer cells
... Background: Liver transplantation is an important treatment option for patients with liver-originated tumors including biliary tract carcinomas (BTCs). Post-transplant tumor recurrence remains a limiting ...
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Biliary tract cancer: current challenges and future prospects
... Purpose: Incidence and mortality of biliary tract carcinoma (BTC) are increasing, especially in South America and Asia. Such a disease often bears a dismal prognosis because of diagnosis occurring at late ...
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Biliary tract large cell neuroendocrine carcinoma: current evidence
... and biliary tract from adenocarcinoma is particularly important be- cause the treatment modality, chemotherapy agents, and options for supplemental treatments differ [6, ...
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Characterisation of the immune-related transcriptome in resected biliary tract cancers.
... BTC, biliary tract cancer; CCA, cholangiocarcinoma; ECC, extrahepatic CCA; ICC, intrahepatic CCA; GBC, gallbladder cancer; RFS, relapse-free survival; TT, tumour tissue; AT, adjacent tissue; FFPE, formalin ...
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Intraductal papillary neoplasm of extrahepatic biliary tract with an associated early invasive adenocarcinoma
... the biliary tract is the clinicopathological condition which was previously referred to as biliary papillomatosis ...atypical biliary epithelium over a delicate fibrovascular stalk that may ...
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Relationship between UGT1A1*6/*28 polymorphisms and severe toxicities in Chinese patients with pancreatic or biliary tract cancer treated with irinotecan-containing regimens
... neutropenia or delayed-onset diarrhea occurred, the dose of irinotecan was reduced to 80% in subsequent cycles. In the case of liver dysfunction due to biliary tract obstruc- tion, the therapy was ...
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New and emerging treatment options for biliary tract cancer
... Abstract: Biliary tract cancer (BTC) is a group of relatively rare tumors with a poor prognosis. The current standard of care consists of doublet chemotherapy (platinum plus gemcitabine); however, even with ...
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ENVIRONMENTALLY BENIGN PROTOCOL FOR THE SYNTHESIS OF SOME NOVEL OXADIAZINANE 4 THIONE DERIVATIVES AS PROMISING AGENT IN BILIARY TRACT DISORDERS TREATMENT
... Heterocycles containing nitrogen and oxygen have received significant attention because of the unique chemical as well as physical properties of different heterocyclic compounds. Six- membered heterocyclic rings with ...
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Practical Use of Gemcitabine and Cisplatin Combination Therapy as First Line Treatment for Japanese Patients with Advanced Biliary Tract Cancer
... Biliary tract cancer (BTC) is a rare type of cancer world- wide, but it is more common in East Asia and Latin America than in other regions [1]. In Japan, BTC is the sixth leading cause of death from cancer ...
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Original Article Clinicopathological significance of stanniocalcin-2 expression in adenocarcinomas of biliary tract
... Abstract: Background: Despite all efforts, patients with biliary tract cancer (BTC) still share a dismal outcome. Based on its lack of specific symptoms, BTCs are often diagnosed in an advanced stage. ...
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Preclinical activity of EGFR and MEK1/2 inhibitors in the treatment of biliary tract carcinoma
... Biliary tract carcinomas (BTC) are malignant tumors with limited therapeutic options. Clinical experiences with anti-EGFR therapies have produced unsatisfactory results. The strategies of combined ...
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Study of Repeat Intervention in Benign Biliary Tract Diseases
... This is to certify Dr.A.ANBU SASIVANNAN a bonafide MS General Surgery Post Graduate Student, from Government Royapettah Hospital, Kilpauk Medical College, Chennai-600 010 has submitted the dissertation on “STUDY OF ...
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Bile Acid Analysis in Biliary Tract Cancer
... of biliary tract cancer is obscure, but there are evidences that bile acid plays a role in ...between biliary tract cancer and bile acid, this study compared the bile acid concentration and ...
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Rhabdomyosarcoma of the biliary tract: a case report
... the biliary tract is a rare tumor that commonly arises from the common bile ...of biliary tree ...the biliary tract is a rare tumor, it should be considered in the differential ...
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CONGENITAL ATRESIA OF THE EXTRAHEPATIC BILIARY TRACT
... Normal drainage of bile from the liver never had been present in these cases of congenital bibiary atresia; nevertheless, considerable regeneration of hepatic cells had occurred. adjacen[r] ...
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<p>Efficacy and safety of nivolumab for metastatic biliary tract cancer</p>
... All patients were required to show more than 1% tumor PD-L1 expression. However, there are few studies about nivolumab and BTCs, although nivolumab and pembrolizumab are the same type[r] ...
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Transcatheter arterial chemoembolization with gemcitabine and oxaliplatin for the treatment of advanced biliary tract cancer
... Between July 2009 and December 2013, a total of 65 patients with advanced BTC were included in the current study. Baseline patient characteristics are reported in Table 1. The study population included 38 men and 27 ...
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Percutaneous transhepatic and endoscopic biliary drainage for malignant biliary tract obstruction: a meta analysis
... Our meta-analysis has some limitations. First, relatively few RCTs have been conductedin which investigators compared the outcomes and complication rates of can- cer patients treated with PTBD or EBD. Second, both Speer ...
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HER2/neu-directed therapy for biliary tract cancer
... Several therapeutic agents have been developed for HER2/neu positive breast cancer: these include monoclo- nal antibodies such as trastuzumab and pertuzumab, small molecule tyrosine kinase inhibitors like lapatinib, and ...
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