6-bisphosphatase
Partial purification and characterisation of cytosolic Fructose-1, 6-bisphosphatase from Drymaria cordata
... Abstract: Drymaria cordata is an important ethnomedicinal plant from which many important secondary metabolites have been reported. Partial purification of the enzyme, fructose 1,6-bisphosphatase was carried out ...
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A summary of molecular genetic findings in fructose-1,6-bisphosphatase deficiency with a focus on a common long-range deletion and the role of MLPA analysis
... Fructose-1,6-bisphosphatase (FBP1) deficiency [OMIM: 229700], first described in 1970 [1], is an inborn error of gluconeogenesis. Patients present with ke- totic hypoglycemia and lactic acidosis triggered by ...
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Original Article Fructose-1,6-bisphosphatase 1 can be a potential predictive marker for the prognosis of hepatocellular carcinoma patients
... It has been verified [15] that FBP1 functions to antagonize glycolysis. As is well known, cancer cells have a higher rate of aerobic glycolysis, but not oxidative phosphorylation [5]. Fructose- 1,6-bisphosphate is one of ...
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Overexpression of 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production
... Hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is an important regulatory enzyme of glucose ...enzyme 6-phosphofructo-1-kinase and an inhibitor of the gluconeogenic enzyme fructose- ...
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Case Report Fructose 1,6-bisphosphatase deficiency: clinical manifestations and genetic features in two Chinese patients
... Abstract: Fructose 1,6-bisphosphatase (FBPase) deficiency is a rare disease that is caused by mutations of FBP1 gene. We report our experience with two Chinese patients with FBPase deficiency. Two Chinese infants ...
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Gluconeogenic Fructose 1, 6-bisphosphatase from Ginkgo biloba L.: Isolation and characterization
... Fructose -1,6- bisphosphatase enzyme (FBPase, EC: 3.1.3.11) in soluble and particulate forms, is considered to be related with two vital biochemical events namely gluconeogenesis and photosynthesis. This enzyme ...
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Fructose 1,6-bisphosphatase 2-Camk2 interaction is an integral mechanism of long-term potentiation
... Similarly strong depolarization of mitochondria we observed after partial silencing of Fbp2 expression with siRNA ( Figure 3A ). This reinforces the hypothesis that the Fbp2 interacti[r] ...
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Reduction in sucrose contents by downregulation of fructose-1,6-bisphosphatase 2 causes tiller outgrowth cessation in rice mutants lacking glutamine synthetase1;2
... the wild type are in red boxes, while metabolites that decreased in the basal portions of the gs1;2 mutant shoots relative to those of the wild type are in blue boxes (P < 0.05 by Student ’ s t-test). Open boxes ...
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Isolation of Degradation-Deficient Mutants Defective in the Targeting of Fructose-1,6-bisphosphatase into the Vacuole for Degradation in Saccharomyces cerevisiae
... This glucose-induced protein degrada- tion occurs primarily in the vacuole, as p q 4 mutants block the induced protein degradation in response to glucose (CHIANC et a[r] ...
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Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity
... We have shown previously that ionizing radiation (IR) upregulates PD-L1 expression in various cancer cell lines [13]. We examined whether IR affects STAT3 phosphorylation and FBP1-STAT3 interaction. While IR increased ...
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The intracellular site of synthesis of fructose 1,6 bisphosphatase in rat liver : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University
... fructose 6-phos phate ( F6 P ) ( Roche and Bouch i l l oux , 1950 ; Pogel l and McGi l very , 1952 ) , and a rol e in mamma l i an fructose metabol i sm was es tabl i s hed ( Hers and Kusaka , 1953 ; Leutha rdt et ...
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Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
... Compared to WT, FBP1 KI mice exhibited similar blood glucose, plasma insulin, glucagon and leptin levels, as well as hepatic glycogen content under fasted and refed 4 h ad libitum follow[r] ...
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The Gluconeogenic Enzyme Fructose-1,6-Bisphosphatase Is Dispensable for Growth of the Yeast Yarrowia lipolytica in Gluconeogenic Substrates
... We have also shown that the expression of the genes encod- ing gluconeogenic enzymes in Y. lipolytica is not regulated in parallel and that YlFBP1 is not repressed by glucose. Catabo- lite repression is very strong in S. ...
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Enhancement of photosynthetic capacity in Euglena gracilis by expression of cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphosphatase leads to increases in biomass and wax ester production
... to create useful E. gracilis strains capable of producing in- dustrially feasible biodiesel. One of the strategies used to enhance algal productivity is optimization of the photo- synthetic pathway. The rate-limiting ...
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Succinic Acid Monoethyl Ester and Metformin Regulates Carbohydrate Metabolic Enzymes and Improves Glycemic Control in Streptozotocin-Nicotinamide Induced Type2 Diabetic Rats
... Objective. Succnic acid mono ethyl ester (EMS) was recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. In the present study the effect of EMS and Metfor- min on the ...
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Hypoglycaemic Activity of Tissue cultured and Field grown Plants of Tinospora cordifolia
... A protocol was established for rapid clonal propagation of the valuable medicinal plant, Tinospora cordifolia. Best shoot induction was observed on MS basal medium supplemented with 4.36 µM KIN produces 2.32 0.1 cm ...
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Examination of the leaf proteome during flooding stress and the induction of programmed cell death in maize
... Figure 4 Quantitative real-time PCR analysis of the mRNA expression levels of differentially expressed proteins under flooding treatment for 0, 1, 2, 3, 4 d. PEPCK: phosphoenolpyruvate carboxykinase; Fbp: ...
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International practices in the dietary management of fructose 1-6 biphosphatase deficiency
... 1, 6 bisphosphatase (FBPase) deficiency (OMIM #229700), is a rare, autosomal recessive inherited disorder of gluconeogenesis ...of 6 months following severe metabolic acidosis probably with the same ...
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Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor
... of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4), a regulatory enzyme that synthesizes an allosteric activator of glycolysis, fructose-2,6- ...
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Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)
... 2 PFK15 reduces proliferation and induces death in MIA PaCa-2 but not human pancreatic stellate cells: PDAC cell lines:MIA PaCa-2, BxPC-3 and PANC1 were treated with 0.3 – 10 μ M PFK15 f[r] ...
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