bisphosphonate treatment
Atypical Femoral Fractures in a Patient with Continuous Decreasing BMD after Only 1 5 Years of Bisphosphonate Treatment
... line treatment for osteoporosis. Long-term bisphosphonate treatment has been reported to be complicated with osteonecrosis of jaw (ONJ) and atypical fracture of ...of bisphosphonate ...
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The effect of bisphosphonate treatment on the biochemical and cellular events during bone remodelling in response to microinjury stimulation
... defect by drawing the needle through the hydrogel at a right angle to the point of insertion to create a defect 7 mm in length and 5 mm in depth. After 72 h of culture, conditioned medium samples were collected. The term ...
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The effect of bisphosphonate treatment on osteoclast precursor cells in postmenopausal osteoporosis: The TRIO study
... with bisphosphonate treatment may be mediated by circulating levels of ...that bisphosphonate treatments had no direct effect on circulating levels of RANKL and ...of treatment, ...no ...
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Effectiveness of Statin and Bisphosphonate Treatment in a 3NP model of Huntington’s Disease
... A member of the Ras protein signaling family, Rhes, is expressed abundantly and selectively in striatal neurons (Falk et al., 1999). Due to its restricted expression, the Rhes protein has become a promising target for ...
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Current perspectives on bisphosphonate treatment in Paget’s disease of bone
... effective treatment to suppress the excessive bone turnover in patients with Paget’s disease of ...to treatment benefits, the decision to treat asymptomatic patients should be individualized with careful ...
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Bisphosphonate Treatment in a Patient Affected by MPS IVA with Osteoporotic Phenotype
... Nonsteroidal anti-inflammatory drugs (NSAIDs) were therefore commenced. However, after a three-week treatment protocol, no significant improvement was observed. On the contrary, the patient manifested a gradual ...
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Gastrointestinal tolerability with ibandronate after previous weekly bisphosphonate treatment
... GI symptoms were assessed with questions selected from the OPSAT-Q™ in both trials (Figure 1). Scores from the selected OPSAT-Q™ questions were compared at screening (previous treatment) and months 1, 4, 7, and 10 ...
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Effect of Bisphosphonate on Osteoclast of Bone
... by bisphosphonate treatment on rat ...the bisphosphonate administration, osteoclast decreased significantly in ...areas. Bisphosphonate induced apoptosis of osteoclasts, which was ...
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Ibandronate: the first once-monthly oral bisphosphonate for treatment of postmenopausal osteoporosis
... the treatment and prevention of postmenopausal ...nitrogen-containing bisphosphonate specifically developed for administration with long dose-free ...to bisphosphonate treatment, thereby ...
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Bone turnover is adequately suppressed in osteoporotic patients treated with bisphosphonates in daily practice
... Our present study is the first demonstrating a rapid and significant decrease of BTMs in the first months of treat- ment with bisphosphonates and a reduction of BTMs to premenopausal levels in almost all osteoporotic ...
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Gastrointestinal events and association with initiation of treatment for osteoporosis
... OP treatment was not initiated; it may reflect a clinical decision not to prescribe treatment or the failure of a patient to fill a ...OP treatment initiation and receipt of a bisphosphonate ...
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Is bisphosphonate therapy for benign bone disease associated with impaired dental healing? A case controlled study
... highlighted the possible association between bispho- sphonate use, especially intravenous (IV) zoledronate or pamidronate, and jaw osteonecrosis [15-21]. Other stu- dies have not found any association between bishospho- ...
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Markers of bone turnover for the management of patients with bone metastases from prostate cancer
... the bisphosphonate pamidronate (120 ...After bisphosphonate treatment all three resorption markers significantly decreased by an average of 65% (P = ...of treatment with ...
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Patterns and predictors of osteoporosis medication discontinuation and switching among Medicare beneficiaries
... initiating bisphosphonate treatment using a 5% random sample of Medicare beneficiaries with at least 24 months of traditional fee-for-service and part D drug coverage from 2006 through ...original ...
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Utilization of bone densitometry for prediction and administration of bisphosphonates to prevent osteoporosis in patients with prostate cancer without bone metastases receiving antiandrogen therapy
... mine treatment differences by patient characteristics such as age group, race, clinical stage, and SEER registry geographic ...and bisphosphonate treatment, age, race, tumor stage at diagnosis, and ...
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Mevalonate kinase deficiency: current perspectives
... Notes: Loss of mevalonate kinase activity leads to a cellular isoprenoid deficiency, which can also be mimicked experimentally with statin or bisphosphonate treatment. 1) Activation of monocytes or ...
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Cyclic bisphosphonate therapy reduces pain and improves physical functioning in children with osteogenesis imperfecta
... As expected, children with more severe forms of OI have more pain at baseline than children with milder forms of OI. While exploratory, our findings suggest that more severely affected OI patients have greater ...
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Zoledronate in the prevention of Paget's (ZiPP) : protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent SQSTM1-mediated Paget's disease of bone.
... the treatment of choice for PDB, and within the bisphosphonates, zoledronic acid (ZA) is most likely to give a favourable response in terms of bone ...for bisphosphonate treatment in PDB is bone pain ...
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Bisphosphonate therapy for spinal osteoporosis in Hajdu-Cheney syndrome – new data and literature review
... Background: Hajdu-Cheney syndrome (HCS) (#OMIM 102500) is a rare, autosomal dominant condition that presents in early childhood. It is caused by mutations in the terminal exon of NOTCH2 , which encodes the transmembrane ...
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Original Article Role of microbiota and inflammation in osteonecrosis of the jaw
... Osteonecrosis of the jaw is currently one of the most important complications in patients receiving bisphosphonate treatment or radio- therapy of the head and neck. However, despite the extensive literature ...
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