Blast Crisis
Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia
... Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by BCR-ABL fusion gene [1]. The disease is triphasic, starting with an initial chronic phase (CP), spontaneous progression to an accelerated ...
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FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphocytic leukemia
... The natural history of CML is characterized by the progression from an indolent chronic phase (CP) to an aggressive myeloid or lymphoid blast crisis (BC) phase (7), a disease stage biologically similar to ...
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Blast crisis Ph+ chronic myeloid leukemia with NUP98/HOXA13 up-regulating MSI2
... Notch1 inhibitor Numb, and loss of the proliferation/ differentiation equilibrium in hematopoietic stem cells (HSCs) [13]. De-regulation of the Musashi-Numb-Notch1 signaling axis is associated with poor prognosis in CML ...
7
ARE/SUZ12 dual specifically-regulated adenoviral TK/GCV system for CML blast crisis cells
... CML blast crisis-derived cell lines com- pared to HepG2 ...six blast phase patients, we used qRT-PCR and observed significant increases in SUZ12 and Nrf2 in blast crisis samples ...
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Knock-down of Kaiso induces proliferation and blocks granulocytic differentiation in blast crisis of chronic myeloid leukemia
... We studied the localization and the role of Kaiso in the cell differentiation status of the K562 cell line, established from a CML patient in blast crisis. Using western blot and immunofluorescence we found ...
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Deletion 9p23 to 9p11.1 as sole additional abnormality in a Philadelphia positive chronic myeloid leukemia in blast crisis: a rare event
... Results: A complete cytogenetic and molecular cytogenetic analysis, molecular biology method (reverse transcription polymerase chain reaction (RT-PCR)), and immunophenotype confirmed to be a CML case in blast ...
5
<p>Myeloid Blast Crisis of Chronic Myeloid Leukemia Followed by Lineage Switch to B-Lymphoblastic Leukemia: A Case Report</p>
... myeloid blast crisis and fi brosis. A diagnosis of myeloid blast crisis from CML was made, and the patient was treated with imatinib (600 mg daily) and hydroxyurea (2000 mg ...2% blast ...
6
Masked inv dup(22)(q11.23), tetrasomy 8 and trisomy 19 in a blast crisis-chronic myeloid leukemia after interrupted Imatinib-treatment
... changes. Blast crisis (BC) is characterized by the rapid expansion of a population of differentiation arrested blast cells (myeloid or lymphoid cells population), often presenting with secondary ...
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Heralding Extramedullary Blast Crisis: Horner’s Syndrome with Brachial Plexopathy in a Patient with Chronic Myelogenous Leukemia
... of Horner’s syndrome with associated arm pain, weakness, and sensory deficit localized the level of his lesion to a second-order syndrome. Further targeted investigations led to the diagnosis of CML in extramedullary ...
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Lymphoblastic Conversion in Chronic Myelogenous Leukemia
... Recently Moore’7 published data concerning soft agar culture growth parameters in 36 patients during the blast crisis phase of Ph’ chromosome- positive CML and has been able to separate [r] ...
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Biomarkers for determining the prognosis in chronic myelogenous leukemia
... Prognostic impact of additional cytogenetic aberrations (ACAs). ACAs are documented in 10%-15% of newly diagnosed patients before TKI treatment [22]. In a retro- spective analysis of the German CML Study IV, patients ...
9
Treatment and monitoring of Philadelphia chromosome-positive leukemia patients: recent advances and remaining challenges
... BC: Blast crisis; CHR: Complete hematologic response; CM: Compound mutation; CML: Chronic myeloid leukemia; CP: Chronic phase; DFS: Disease-free survival; DMR: Deep molecular response; EBMT: European ...
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Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes
... Phosphorylation of eIF2α was demonstrated to modify level of ATF4 protein synthesis at the step of mRNA translation [32]. On the other hand, according to the Nencki Genomics Database [33], which contains consensus ...
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Applying the discovery of the Philadelphia chromosome
... Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib STI571 in chronic phase and blast crisis chronic myeloid leukemia.. BCR-AB[r] ...
9
Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy
... Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Yu HA[r] ...
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Activation of the hedgehog pathway in chronic myelogeneous leukemia patients
... were divided into three groups: chronic phase (CP), accelerated phase (AP) and blast crisis (BC). In addition, 38 CML-CP patients were divided into two groups: 31 treated with imatinib,7 treated with ...
5
Phorbol diester induced macrophage differentiation of leukemic blasts from patients with human myelogenous leukemia
... 11 patients had acute myeloblastic leukemia, 4 had acute myelomonocytic leukemia, 4 had myeloid blast crisis of chronic myelogenous leukemia CML, 1 had lymphoid blast crisis of CML, 3 ha[r] ...
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Cost–utility analysis of imatinib mesilate for the treatment of advanced stage chronic myeloid leukaemia
... The effectiveness data used for this study was obtained from the manufacturer of Imatinib (Novartis). These data are reported elsewhere (Capdeville and Gathmann, 2001, Kantarjian et al, 2002; Sawyers et al, 2002). In ...
7
BCR ABL kinase is dead; long live the CML stem cell
... Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib STI571 in chronic phase and blast crisis chronic myeloid leukemia.. Overri[r] ...
5
Response to Imatinib Mesylate in patients with Chronic Myeloid Leukemia.
... Hydroxyurea (Hydrea) was introduced. Being less toxic than Busulfan and non toxic to stem cells, this became popular. Randomized studies showed prolonged survival over busulfan. In the 60s and in the 80’s the median ...
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