Blood brain barrier
Characteristics of compounds that cross the blood-brain barrier
... the blood-brain barrier (BBB) by a variety of ...However, brain-to-blood efflux systems, enzymatic activity, plasma protein binding, and cerebral blood flow can greatly alter the ...
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How Glutamate Is Managed by the Blood-Brain Barrier
... the blood brain barrier (BBB) that has been tacitly assumed to be a path for glutamate entry to ...whose brain content is much greater than plasma, and studies in vivo show that glutamate does ...
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VEGF enhances angiogenesis and promotes blood brain barrier leakage in the ischemic brain
... VEGF is a secreted mitogen associated with angiogenesis and is also a potent vascular permeability factor. The biological role of VEGF in the ischemic brain remains unknown. This study was undertaken to ...
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Entry of Bilirubin into the Brain Due to Opening of the Blood-Brain Barrier
... Serum albumin readily enters the brain following osmotic opening of the blood-brain barrier.25 How- ever, the albumin concentration varies within the brain, and the regional pattern appr[r] ...
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Optimization of the Ultrasound-Induced Blood-Brain Barrier Opening
... selective brain drug delivery method. The brain is particularly difficult to deliver drugs to because of the blood-brain barrier ...the brain healthy also constitute the cause of ...
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Does sumatriptan cross the blood–brain barrier in animals and man?
... Abstract Sumatriptan, a relatively hydrophilic triptan, based on several animal studies has been regarded to be unable to cross the blood–brain barrier (BBB). In more recent animal studies there are ...
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Blood-brain barrier derangement after electrical brain stimulation
... Noninvasive brain stimulation methods, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation (tDCS), have received considerable attention in recent years for use in the ...
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Current concepts of blood brain barrier development
... the brain tissue, together with the complementary observa- tion of his associate Edwin ...the brain tissue, has lead to the concept of a biological barrier between blood and brain (for ...
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Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders
... the brain, accumulation of GCs may induce epileptic discharges and ...the brain under physiological and pathological ...the blood-brain barrier (BBB) and the blood-cerebrospinal ...
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Blood-brain barrier impairment in MPS III patients
... the blood-brain barrier (BBB) competence may be critical to identifying poten- tial additional mechanisms of this devastating ...the brain and removing toxic waste products from the ...
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Effect of Serum Hyperosmolality on Opening of Blood-Brain Barrier for Bilirubin in Rat Brain
... Effect of Serum Hyperosmolality on Opening of Blood-Brain Barrier for Bilirubin in. http://pediatrics.aappublications.org/content/71/6/909[r] ...
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MG53 permeates through blood-brain barrier to protect ischemic brain injury
... IR-induced brain injury increases permeability of the blood-brain-barrier, providing access of MG53 from blood circulation to target the injured brain ...alleviate brain ...
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Possible strategies to cross the blood–brain barrier
... The mucopolysaccharidoses (MPS) are a heterogeneous group of in-born metabolic conditions caused by genetic defects that result in the absence or severe deficiency of one of the lysosomal hydrolases responsible for the ...
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Passing across the blood-brain barrier in glioblastoma multiforme (GBM)
... Blood-brain barrier (BBB) consists of capillary endothelium, in which there are three types of intercellular junctions - adherent, tight and gap ...functioning. Blood vessels of the central ...
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Drug Permeation across the Blood-Brain Barrier: Applications of Nanotechnology
... The blood-brain barrier (BBB) is a neurobiological frontier that isolates brain tissues from the blood vascular ...the brain and the central nervous system from external ...
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Hypertensive encephalopathy and the blood brain barrier: is δPKC a gatekeeper?
... Hypertensive encephalopathy is a life-threatening condition due to elevation of cerebral perfusion pressure beyond the limits of autoregulation. Breakdown of the blood-brain barrier (BBB) leads to ...
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What is the blood brain barrier (not)?
... the brain parenchyma, Peter Medawar established that the efferent arm was relatively intact ...the brain submit to but cannot elicit an immune ...the brain parenchyma of rats and allowed the mild ...
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The blood brain barrier in neuropsychiatric disorders
... a barrier between substances in the blood and brain and led Lewandowsky to coin the term “blood-brain barrier”, it wasn’t until several years later when Ehrlich’s student Edwin ...
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Blood-brain Barrier Remodeling during Brain Metastasis Formation
... membrane barrier is achieved though active proteolysis by matrix metalloproteinases (MMPs) ...the blood or lymphatic vessels ...the blood–brain barrier ...in brain metastatic ...
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Blood Brain Barrier Disruption after Cardiac Surgery
... for blood-brain barrier disruption following treatment with IV- TPA, independent of impaired kidney ...with blood-brain barrier opening after reperfusion in rat ...
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