Blood–brain barrier disruption
Osmotic blood brain barrier disruption Computerized tomographic monitoring of chemotherapeutic agent delivery
... methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized ...
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MR and cognitive testing of patients undergoing osmotic blood brain barrier disruption with intraarterial chemotherapy
... osmotic blood-brain barrier modi- fication with intraarterial chemotherapy is used, the procedure has resulted in 50- to 100-fold increased delivery of chemotherapeutic agent as compared with ...
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Osmotic blood brain barrier disruption: CT and radionuclide imaging
... A, CT scan after an osmotic blood-brain barrier disruption in the right internal carotid artery on patient 15 shows a grade 3 excellent disruption in the right middle cerebral artery ter[r] ...
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Flat Detector Angio CT following Intra Arterial Therapy of Acute Ischemic Stroke: Identification of Hemorrhage and Distinction from Contrast Accumulation due to Blood Brain Barrier Disruption
... 1. Blood-brain barrier disruption (asterisks) and subarachnoid hemorrhage (arrows) following combined intra-arterial thrombolysis (1,000,000 U of urokinase) and thrombectomy in a 62-year-old ...
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Behavioral alterations following blood-brain barrier disruption stimulated by focused ultrasound
... The purpose of this study was to investigate the behavioral alterations and histological changes of the brain after FUS-induced BBB disruption (BBBD). Rats were behaviorally tested using the open field, ...
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PRDX6 controls multiple sclerosis by suppressing inflammation and blood brain barrier disruption
... mouse brain among the six mammalian PRDXs (PRDX1 - 6) [10], and it also was reported to be elevated in reactive astrocytes of human PD patients and dementia patient brains [11], and implying unique roles of PRDX6 ...
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Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy
... The regulation and cell specificity of Poldip2 remain poorly understood [25]. Here, we found that LPS mod- estly induced Poldip2 expression in cerebral cortices and staining of these cortices showed strong induction of ...
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Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
... of brain injury (Dirnagl et ...significant disruption of the blood-brain barrier (BBB) followed by a massive infiltration of polymorphonuclear (PMN) leukocytes (Rosenberg et ...in ...
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Blood–brain barrier disruption in CCL2 transgenic mice during pertussis toxin-induced brain inflammation
... BBB disruption was determined by calculating the percentage of pixels with a contrast enhancement above 20 % within the brain on calculated percent difference ...the brain showing enhancement above ...
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Astrocyte derived VEGF A drives blood brain barrier disruption in CNS inflammatory disease
... needed. Disruption of the blood-brain barrier (BBB) is an early feature of lesion formation that correlates with clinical exacerbation, leading to edema, excitotoxicity, and entry of serum ...
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State-of-the-art of microbubble-assisted blood-brain barrier disruption
... immune cells in the brain and are critical for monitoring the brain for pathogens and foreign molecules, as well as responding to injury. Activation of microglia is readily detected using antibodies to cell ...
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Blood Brain Barrier Disruption after Cardiac Surgery
... Initially we enrolled patients in this study before surgery (patients in group 1). After several months, it became clear that it was not practical to enroll and receive consent from patients before sur- gery. Because the ...
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Bacterial induction of Snail1 contributes to blood brain barrier disruption
... traumatic brain injury (51), decreased ZO-1 and claudin 5 expres- sion in brain endothelium during HIV infection (52, 53), and reduced occludin and claudin 5 expression in BBB endothelium during ischemic ...
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Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion
... tMCAO was carried out as previously described [21]. Adult CD1 mice weighing 30 ± 5 grams were anesthetized with ketamine/xylazine (100 mg/10 mg/kg; Sigma, St. Louis, MO, USA) through intra-peritoneal injection. After ...
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The Application of MRI for Depiction of Subtle Blood Brain Barrier Disruption in Stroke
... detecting blood-brain-barrier (BBB) disrup- tion may help predict stroke patient's propensity to develop hemorrhagic complications following ...BBB disruption and high spatial ...BBB ...
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Hungerhuber, Edwin (2003): Neuroprotektion bei fokaler zerebraler Ischämie. Dissertation, LMU München: Medizinische Fakultät
... Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood- brain barrier disruption, brain edema, and neuronal damage volume after t[r] ...
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Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption
... The observation that perforin is a key regulator of BBB disruption is intriguing. In humans, the perforin allele has extensive single nucleotide variants (SNVs) [18–27]. Clinically, perforin SNVs are viewed ...
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Voluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood–brain barrier
... the brain endothelium and the BBB func- tions ...electrical barrier, fence and signaling functions of TJs ...cultured brain endothelial cells [10] and brain capillaries in the current ...
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Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier
... BBB disruption via endothelial nitric oxide synthase (eNOS)-mediated downregulation of Claudin-5 and Occludin [40, ...BBB disruption, by the demonstrations that meningitic ...
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Human Immunodeficiency Virus Type 1 Infection Increases the In Vivo Capacity of Peripheral Monocytes To Cross the Blood-Brain Barrier into the Brain and the In Vivo Sensitivity of the Blood-Brain Barrier to Disruption by Lipopolysaccharide
... Although there are differences between the biological be- haviors of murine and human mononuclear phagocytes such as microglia and macrophages, mouse models provide informa- tive in vivo systems for studying BBB function ...
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