Blood–brain barrier integrity
Viral Pathogen Associated Molecular Patterns Regulate Blood Brain Barrier Integrity via Competing Innate Cytokine Signals
... vealed that deficiencies in each of these pathways result in in- creased disease susceptibility, including early neuroinvasion and greater CNS viral burdens during WNV infection (27, 50, 51). Of note, unlike other PRRs, ...
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Candesartan Attenuates Ischemic Brain Edema and Protects the Blood–Brain Barrier Integrity from Ischemia/Reperfusion Injury in Rats
... ischemic brain edema need to be ...the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in ...arterial blood pressure, ...
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Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria
... and competitively binds to Tie2, where it promotes vas- cular permeability and instability [43, 44]. Absolute levels and the ratio between Ang-1 and Ang-2 are associated with disease severity and fatality in CM [39–41, ...
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Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood–brain barrier integrity?
... Cytoadherence and decreased pliability are the main mechanisms underlying vascular obstruction [9,17-21]. It is speculated that cytoadherence evolved as a mechan- ism for the parasite to evade triggering a host immune ...
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In vivo magnetic resonance imaging for assessing the integrity of the blood-tumour barrier in a mouse model of melanoma brain metastasis
... In this study we have shown that MRI can be used to characterize a clinically relevant model of brain metastasis; there are however some limitations that should be addressed. First, the two MRI scans were ...
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TLR2-induced astrocyte MMP9 activation compromises the blood brain barrier and exacerbates intracerebral hemorrhage in animal models
... mice. Brain injury volume and neurological deficits following ICH were reduced in TLR2 KO mice compared to wild-type (WT) control ...Heterologous blood-transfer experiments show that TLR2 signaling in ...
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Basement membrane and blood–brain barrier
... The blood–brain barrier (BBB) is a highly complex and dynamic structure, mainly composed of brain microvascular endothelial cells, pericytes, astrocytes and the basement membrane ...
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<p>The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study</p>
... fractional blood plasma volume were correlated with the severity of BG-EPVS (OR: ...BBB integrity, supporting the hypothesis that the BBB dysfunction may be involved in the pathogenesis of ...disease, ...
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The blood brain barrier in neuropsychiatric disorders
... for brain-wide knockdown of ...entire brain produced permeability of the BBB that resulted in impairments in learning and memory and increased ...the integrity of the BBB was ...BBB integrity ...
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Claudin 5: Gatekeeper of neurological function
... leaky barrier contributes to the generation of seizures, leading to more seizures which trigger further barrier dysfunction leading to epilepsy progression ...of blood vessels associated with this ...
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VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult
... examine integrity of blood- brain barrier ...into brain tissue was visualized on five striatal brain sections (spaced 200 μm apart) under a fluorescent micro- scope to determine ...
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Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood Brain Barrier Leakage in Experimental Viral Encephalitis
... FIG 7 IFN- ␥ induces junctional disorganization through ROCK in brain endothelial cells. (A) Transcript expression of cytoskeletal modulators (Rac1, Rhoa, Rhoc, Rhog, Rhoj, ROCK1, and ROCK2) after 24 h of vehicle ...
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An In-silico Approach to Explore the Possible Multifunctional Neuroprotective Efficacy of Violacein against Ischemic Stroke
... improper blood supply to brain due to haemorrhage and occlusions, which leads to inability to meet the metabolic demand and results in decreased supply of oxygen and glucose to brain cells ...
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Trojan Horse Transit Contributes to Blood Brain Barrier Crossing of a Eukaryotic Pathogen
... the brain. Due to the presence of extremely tight junctions in brain endothelia, transendothelial pore transit accounts for up to 90% of cellular crossing of the BBB, in contrast to other endothelia, where ...
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NIH workshop report on the trans-agency blood–brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface
... Dr. William Banks emphasized that the BBB acts as a complex interface regulating the exchange of nutrients, informational molecules, and other substances between the CNS and blood. The properties of this interface ...
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Online Full Text
... As mentioned in Section II the permeability measure should be qualitative rather than quantitative. This is due to the fuzzy nature of measurement and lack of persistence. For example, plasma to brain ratio of ...
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Breast cancer brain metastases: biology and new clinical perspectives
... of brain lesions (17 %) did the lapatinib con- centration approach that of systemic metastases ...the brain and that drug delivery to BM is variable and in many cases appears partially limiting ...
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Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
... related blood-spinal cord barrier (BSCB) in other animal models of neurological disease, including stroke [56, 57], intracerebral hemorrhage [58], intracerebral LPS injection [59], MPTP toxicity [60] and ...
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Brain-targeting study of stearic acid–grafted chitosan micelle drug-delivery system
... Biodistribution study of CS-SA/DOX micelles was carried out in ICR mice in comparison with DOX HCl. CS-SA/DOX micelles and DOX ⋅ HCl solution were injected via tail vein of ICR mice, both at a dose of 2.5 mg DOX/kg. At 5 ...
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Plasma and cerebrospinal fluid interleukin-1β during lipopolysaccharide-induced systemic inflammation in ewes implanted or not with slow-release melatonin
... (Thermo Fisher Scientific, USA). The integrity of RNA was verified by electrophoresis using 1.2% agar- ose gel stained with ethidium bromide (Sigma Al- drich, USA). To synthesize cDNA, the DyNAmo cDNA Synthesis ...
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