Blood-brain barrier integrity
Candesartan Attenuates Ischemic Brain Edema and Protects the Blood–Brain Barrier Integrity from Ischemia/Reperfusion Injury in Rats
... arterial blood samples were taken from tail artery for the measurements of arterial pH and blood gases at 10 min before and 30 min after MCA occlusion as well as 10 min after the start of ...
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Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria
... peripheral blood mononuclear cells Human peripheral blood mononuclear cells (PMBCs), 5 × 10 5 cells/well were treated with 1 μM dihydro-arte- misinin (DHA) dissolved in ...healthy blood donors. All ...
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Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood–brain barrier integrity?
... Conclusion As suggested by three complementary theories devel- oped over the past century, CM might be a likely conse- quence of several concomitant phenomena, including iRBC sequestration in brain microvessels, ...
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Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity
... BBB integrity may be due to the very young age of mice since previous study reported that Apoe deficiency associated BBB disruption in Alzheimer’s disease , without any other acute injury effects, was ...
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Viral Pathogen Associated Molecular Patterns Regulate Blood Brain Barrier Integrity via Competing Innate Cytokine Signals
... Here, we demonstrate a novel mechanism underlying the dy- namic regulation of BBB structure and function by innate cyto- kines during viral encephalitis. Using an in vitro BBB model, we show that, in the presence of WNV, ...
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The blood brain barrier in neuropsychiatric disorders
... for brain-wide knockdown of ...entire brain produced permeability of the BBB that resulted in impairments in learning and memory and increased ...the integrity of the BBB was ...BBB integrity ...
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Basement membrane and blood–brain barrier
... To investigate laminin’s function in BBB integrity, a variety of laminin loss-of-function mutants have been generated. Global knockout of most laminin subunits, including α5, 52–54 β1 55 or γ1, 55–57 leads to ...
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The blood brain barrier in systemic infection and inflammation
... Solute permeability Emerging evidence suggests that compensatory changes occur at the BBB during the initial stages of systemic in flammation that prevent BBB disruption, such as increased solute permeability. In one ...
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Blood-brain barrier permeability and physical exercise
... autonomic brain areas, which strongly correlates with the improvement of both parasympathetic and sympathetic control of cardiovascular parameters, even in the persist- ence of ...the brain ...
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In vivo magnetic resonance imaging for assessing the integrity of the blood-tumour barrier in a mouse model of melanoma brain metastasis
... In this study we have shown that MRI can be used to characterize a clinically relevant model of brain metastasis; there are however some limitations that should be addressed. First, the two MRI scans were ...
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Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders
... In brain tissues, we analyzed the expression level of genes associated with the formation, integrity, and function of the BBB and neuroinflammation, as follows: Claudin( CLDN) -1, CLDN-3 , CLDN-5 , and ...
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Selective Disruption of the Blood–Brain Barrier by Zika Virus
... The blood–brain barrier (BBB) selectively regulates the cellular exchange of macromolecules between the circulation and the central nervous system ...the brain via a disrupted BBB and altered ...
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Physical insights into the blood brain barrier translocation mechanisms
... flow, volume of distribution of substances, may also play a role [1]. Therefore, the characteristics of the chemical agents and the physical properties of the BBB determine whether a substance will enter the brain ...
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Hypertensive encephalopathy and the blood brain barrier: is δPKC a gatekeeper?
... BBB integrity, as demonstrated by increased BBB permeability and swelling of astrocytes and endothelial cells, and increased mortality, with 60% of salt-fed rats dying by the age of 15 ...
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The restorative role of annexin A1 at the blood–brain barrier
... the brain, as a high fat diet up-regulated expression of toll like receptor 4 (TLR4), high-mobility group protein B1 (HMGB1), vascular endothelial growth factor (VEGF) and COX-2 ...the brain, and further ...
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Neuro-inflammation, blood-brain barrier, seizures and autism
... BBB integrity [43,44]. Recent evidence indicates that the integrity of the BBB, especially leukocyte endothelial adhesion may also be involved in the pathogenesis of epilepsy [45], a phenomenon described as ...
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Blood-brain barrier impairment in MPS III patients
... the blood-brain barrier (BBB) competence may be critical to identifying poten- tial additional mechanisms of this devastating ...the brain and removing toxic waste products from the ...
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Blood-testis barrier integrity depends on Pin1 expression in Sertoli cells
... Sertoli cells create a local tolerogenic microenvironment to maintain testicular immune privilege espe- cially through the formation of the BTB, which separates the inner tubular microenvironment from the rest of the ...
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What is the blood brain barrier (not)?
... The immune privilege of the central nervous system is indispensable for damage limitation during inflammation in a sensitive organ with poor regenerative capacity. It is a longstanding notion which has down the years ...
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Contrast Media, the Blood-Brain Barrier,
... Unlike the water-soluble agents, which enhance not only by their initial intravascular location but also by their passage through abnormal vessels in the lesion or normal vessels which h[r] ...
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