blood-stage malaria
Comparison of statistical models to estimate parasite growth rate in the induced blood stage malaria model
... of malaria parasites in the blood can be assessed by comparing the growth rate of parasitaemia in the blood of subjects treated with a test vaccine compared to ...induced blood stage ...
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A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial
... induced blood stage malaria; GMP: Good Manufacturing Practice; GAP: genetically-attenuated parasites; kahrp: knob-associated histidine-rich protein; MCB: master cell bank; FDA: Food and Drug ...
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cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses
... ongoing blood-stage infection impairs the development of GC-derived humoral immu- nity to blood-stage antigens has clinical ...of blood-stage malaria could reasonably be ...
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Progress in the development of recombinant and synthetic blood stage malaria vaccines
... control blood-stage parasites (Amante and Good, 1997; Brake et ...against blood-stage malaria parasites (for a review, see Wipasa et ...control blood-stage ...human ...
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Dichotomous miR expression and immune responses following primary blood-stage malaria
... human blood-stage infection (CHMI) model utilizing the intravenous injection of ...into malaria- naive volunteers followed by antimalarial chemotherapy ...in malaria-naive human volunteers ...
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Development of cultured Plasmodium falciparum blood stage malaria cell banks for early phase in vivo clinical trial assessment of anti malaria drugs and vaccines
... An important aspect of this culture-based approach is the possibility to take research-grade material through to a final, GMP-grade product. Thus, the lack of access to GMP-grade starting material will not impose ...
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Sample size calculation for multicentre efficacy trials of blood stage malaria antigens
... nical malaria can be considered as “small” in the termi- nology of controlled trials, if it suggests that only about 20 events are expected to occur in the control ...
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ATG8 Is Essential Specifically for an Autophagy Independent Function in Apicoplast Biogenesis in Blood Stage Malaria Parasites
... in blood- and liver-stage Plasmodium as well as the related parasite Toxo- plasma gondii (6, 7, ...in blood-stage Plasmodium falciparum (17), while ATG8 overexpres- sion in liver-stage ...
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Generation of genetically attenuated blood-stage malaria parasites; characterizing growth and virulence in a rodent model of malaria
... Giemsa-stained blood- stages showed that mature Δpm4Δbp2-schizonts were small and left a large volume of the infected RBC (iRBC) unoccupied (occupying only 25–65%), whereas wt-schizonts occupied 60–90% of the host ...
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Generation of Plasmodium falciparum parasite inhibitory antibodies by immunization with recombinantly expressed CyRPA
... leading blood-stage malaria vaccine candidate: it has been shown to induce invasion-inhibitory antibodies that are effective across common PfRH5 genetic variants and PfRH5-based vac- cines can ...
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Antiplasmodial Efficacy of Crude Cocoa Powder Extract on CD4+ T Cell Counts of Plasmodium berghei Infected BALB/c Mice
... of malaria parasites by hepatocytes and ...to malaria, γ T cells have been shown to have the capacity to directly inhibit the parasite ...to malaria, but at different stages. During the liver ...
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Augmented particle trapping and attenuated inflammation in the liver by protective vaccination against Plasmodium chabaudi malaria
... Liver metabolism including phase I and II detoxifications are not only regulated by CAR, but also by other nuclear receptors such as FXR, PXR, and RXR. Here, it is shown that these nuclear receptors are also responding ...
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Chemically attenuated blood-stage Plasmodium yoelii parasites induce long-lived and strain-transcending protection
... of malaria, even if does not completely prevent ...whole blood-stage malaria parasites has been studied using infection and drug-cure systems (15–17); these data provide a strong rationale for ...
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Cysteamine broadly improves the anti plasmodial activity of artemisinins against murine blood stage and cerebral malaria
... with blood-stage replication of ...cerebral malaria associated with neuroinflammation caused by trapping of ...the blood brain barrier [23, 24, ...the blood–brain barrier (BBB) of mice ...
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Lack of allele specific efficacy of a bivalent AMA1 malaria vaccine
... of malaria clinical episodes caused by parasites with AMA1 similar to the vaccine strain with respect to immunologically dominant regions of the AMA1 ...clinical malaria caused by parasites with AMA1 c1L ...
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IgG subclass responses to excreted secreted antigens of Plasmodium falciparum in a low transmission malaria area of the Peruvian Amazon
... Tween-20, 0.05% BSA, 500 mM NaCl) containing 0.5% skim milk before being added to the plate in duplicate and incubated for 1 h at room temperature. The wells were washed four times with AB washing solution to remove any ...
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Up and down modulation of liver cytochrome P450 activities and associated events in two murine malaria models
... of malaria on TBARS and GRP78 expression were similar to the effects of menadione, a pro-oxidant agent non-inducer of CYP2a5, and con- trasted with the effects of pyrazole, a prototypical indu- cer of ...that ...
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Reverse immunodynamics : a new method for identifying targets of protective immunity
... Despite a dramatic increase in our ability to catalogue variation among pathogen genomes, we have made far fewer advances in using this information to identify targets of protective immunity. epidemiological models ...
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Screening for potential prophylactics targeting sporozoite motility through the skin
... inhibition even with large amounts of gel applied, it does suggest that the drug is not able to sufficiently permeate the dermal layer where sporozoites are predominantly located after the bite. Thus, reduced drug ...
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Targeting liver stage malaria with metformin
... Metformin has also been shown to mediate immune modulation, such as enhanced T and B cell effec- tor functions and memory (63–65). Interestingly, a recent study showed that metformin had an effect on the host immunity ...
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